Double-stranded ribonucleic acid as control against insects 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2018010130 A1 2018-01-11 [US20180010130] / 2018-01-11
申请号/申请日
2017US-15709890 / 2017-09-20
发明人
ESTEP III ALDEN S;BECNEL JAMES J;SANSCRAINTE NEIL D;
申请人
US NAVY;US SECRETARY OF AGRICULTURE;
主分类号
IPC分类号
A01N-025/00A01N-063/00C12N-015/113
摘要
(US20180010130) A composition for use in formulations for controlling insect populations, including populations of mosquito and flies.  The composition comprises one or more double-stranded constructs inhibitory to RNA transcription of ribosomal proteins.  The invention also relates to method of using the compositions in formulations to inhibit insect populations.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2014US-62077441 2014-11-10 2015US-14935759 2015-11-09 2017US-15709890 2017-09-20
主权利要求
(US20180010130) What is claimed is: 1.  A composition for controlling insects, comprising double-stranded RNA molecules, wherein said double-stranded RNA molecules encode the small or large ribosomal subunit, wherein said double stranded RNA molecules of said small ribosomal subunit are produced by transcription of nucleic acid sequences encoding a region of the insect ribosomal protein RPS 6, with the nucleotide sequence of SEQ ID NO: 230, and wherein said large ribosomal subunit are produced by transcription of nucleic acid sequences encoding a region of the insect ribosomal protein RPS 26, with the nucleotide sequence of SEQ ID NO: 231. 2. The composition of claim 1, wherein said composition comprises one or more double-stranded RNA molecules encoding mosquito ribosomal proteins, wherein said double-stranded RNA molecules are transcribed from nucleic acid sequences selected from the group consisting of SEQ ID Nos. 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 76, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 109, 112, 115, 121, 124, 127, 130, 133, 136, 139, 142, 146, 149, 152, 155, 158, 161, 164, 167, 170, 173, 176, 179, 182, 185, 188, 191, 194, 197, 200, 203, 206, 209 and 212. 3. The composition of claim 1, wherein said double-stranded RNA is incorporated into insect bait. 4. The composition of claim 1, wherein said double-stranded RNA molecule is included in and expressed from a viral vector. 5. The composition of claim 7, wherein said viral vector is baculovirus vector system. 6. A method of controlling insect populations, comprising inhibiting RNA encoding ribosomal proteins by exposing insects to a formulation comprising the composition of claim 1. 7. The method of claim 6, wherein said formulation is incorporated in insect bait. 8. The method of claim 6, wherein said formulation comprises one or more double-stranded RNA, wherein said double-stranded RNA molecules are transcribed from the nucleic acid sequences selected from the group consisting of SEQ ID Nos. 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 79, 82, 85, 88, 91, 94, 97, 100, 103, 106, 109, 112, 115, 121, 124, 127, 130, 133, 136, 139, 142, 146, 149, 152, 155, 158, 161, 164, 167, 170, 173, 176, 179, 182, 185, 188, 191, 194, 197, 200, 203, 206, 209, 212, 230, and 231. 9. The method of claim 6, wherein said composition is expressed from an insect vector 10. The method of claim 9, wherein said insect vector is baculovirus expression system.
法律状态
(US20180010130) LEGAL DETAILS FOR US2018010130  Actual or expected expiration date=2035-11-09    Legal state=ALIVE    Status=PENDING     Event publication date=2017-09-20  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US15709890  Application date=2017-09-20  Standardized application number=2017US-15709890     Event publication date=2017-09-20  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: WHITEMAN, BRIAN A    Event publication date=2017-09-20  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1674     Event publication date=2017-09-20  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 103235CON    Event publication date=2017-09-20  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 22245    Event publication date=2017-09-20  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=2017-09-20  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=Yes     Event publication date=2017-09-20  Event code=US/APST  Event indicator=Pos  Event type=Examination events  PAIR Application Status    Event publication date=2018-01-11  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2018010130  Publication stage Code=A1  Publication date=2018-01-11  Standardized publication number=US20180010130
专利类型码
A1
国别省市代码
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