Method for producing L-amino acid using microorganism having increased phosphate transporter activity 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2015307907 A1 2015-10-29 [US20150307907]US9476076 B2 2016-10-25 [US9476076]US9506094 B2 2016-11-29 [US9506094] / 2015-10-292016-10-252016-11-29
申请号/申请日
2015US-14796326 / 2015-07-10
发明人
HIRANO SEIKO;HAYASHI KAZUYUKI;
申请人
AJINOMOTO;
主分类号
IPC分类号
C07K-014/34C12P-013/04C12P-013/14
摘要
(US9506094) A method for producing an L-amino acid is provided.  An L-amino acid is produced by culturing a coryneform bacterium having an L-amino acid-producing ability, which is modified so that the activity of a phosphate transporter is increased, in a medium, and collecting the L-amino acid from the medium.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2013JP-0101589 2013-05-13 2013JP-0219274 2013-10-22 2014WO-JP62752 2014-05-13
主权利要求
(US9506094) 1. A method for producing an L-aminoacid comprising: (A) culturing a coryneform bacterium having an L-aminoacid producing ability in a medium; and (B) collecting the L-aminoacid from the medium, wherein the bacterium has been modified to increase the expression of a gene encoding a phosphate transporter, wherein the increased expression of the gene is obtained by increasing the copy number of the gene and/or modifying an expression control sequence of the gene, wherein said phosphate transporter is selected from the group consisting of: (a) a protein which comprises the aminoacid sequence of SEQ ID NO: 6 or SEQ ID NO: 26, (b) a protein which comprises all of SEQ ID NO: 6 or 26 except for the substitution, deletion, insertion or addition of 1 to 10 aminoacid residues, wherein said protein has phosphate transporter activity, (c) a protein which comprises all of SEQ ID NO: 6 or 26 except for the replacement of the aminoacid residue at a position corresponding to position 246 of SEQ ID NO: 6 with a serine residue, and (d) a protein which comprises all of SEQ ID NO: 6 or 26 except for (i) the replacement of the aminoacid residue at a position corresponding to position 246 of SEQ ID NO: 6 with a serine residue, and (ii) the substitution, deletion, insertion or addition of 1 to 10 aminoacid residues, wherein said protein has phosphate transporter activity. 7. A method for producing an L-aminoacid comprising: (A) culturing a coryneform bacterium having an L-aminoacid producing ability in a medium; and (B) collecting the L-aminoacid from the medium, wherein the bacterium has been modified to express a gene encoding a phosphate transporter, wherein said phosphate transporter is selected from the group consisting of: (a) a protein which comprises all of SEQ ID NO: 6 or 26 except for the replacement of the aminoacid residue at a position corresponding to position 246 of SEQ ID NO: 6 with a serine residue, and (b) a protein which comprises all of SEQ ID NO: 6 or 26 except for (i) the replacement of the aminoacid residue at a position corresponding to position 246 of SEQ ID NO: 6 with a serine residue, and (ii) the substitution, deletion, insertion or addition of 1 to 10 aminoacid residues, wherein said protein has phosphate transporter activity.
法律状态
(US9506094) LEGAL DETAILS FOR US2015307907  Actual or expected expiration date=2034-05-13    Legal state=ALIVE    Status=GRANTED     Event publication date=2015-07-10  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US14796326  Application date=2015-07-10  Standardized application number=2015US-14796326     Event publication date=2015-07-10  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: RAMIREZ, DELIA M    Event publication date=2015-07-10  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1652     Event publication date=2015-07-10  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: US-513 Customer Nbr: 38108    Event publication date=2015-07-10  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: UNDISCOUNTED    Event publication date=2015-07-10  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=Yes     Event publication date=2015-07-10  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2015-07-10  Event code=US/PET  Event type=APL  Petition Entered    Event publication date=2015-07-10  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2015-07-10  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2015-07-22  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2015-08-12  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2015-09-11  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: AJINOMOTO CO., INC., JAPAN  Effective date of the event=2015-08-20  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:HIRANO, SEIKO HAYASHI, KAZUYUKI REEL/FRAME:036538/0640     Event publication date=2015-09-14  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2015-10-29  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2015307907  Publication stage Code=A1  Publication date=2015-10-29  Standardized publication number=US20150307907     Event publication date=2015-10-29  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2016-01-12  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2016-02-24  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2016-07-04  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2016-07-08  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2016-09-13  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2016-10-05  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Issue Notification Mailed    Event publication date=2016-10-24  Event code=US/PET  Event type=APL  Petition Entered    Event publication date=2016-10-25  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US09476076  Publication stage Code=B2  Publication date=2016-10-25  Standardized publication number=US9476076     Event publication date=2016-10-27  Event code=US/NOAC  Event type=Examination events  Event type=OAO  Corrected Notice of Allowance    Event publication date=2016-11-09  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Issue Notification Mailed    Event publication date=2016-11-29  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US9506094  Publication stage Code=B2  Publication date=2016-11-29  Standardized publication number=US9506094     Event publication date=2016-11-29  Event code=US/ERNG  All references to Patent No. 9,476,076 to SEIKO HIRANO of Kanagawa, JP for METHOD FOR PRODUCING L-AMINO ACID USING MICROORGANISM HAVING INCREASED PHOSPHATE TRANSPORTER ACTIVITY appearing in the Official Gazette of October 25, 2016 should be deleted since no patent was granted.     Event publication date=2016-11-29  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 0  Overlap Delays: 0  Non Overlap Delays: 0   PTO Office Delays: 0  Applicant Delays: 0  Adjustment total:  Number of days of extension=0
专利类型码
A1B2B2
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