High concentrations of fluoride in drinking water have adverse health effects for consumers. So, the aim of this study was to study the effectiveness of metal organic frameworks for fluoride adsorption. The adsorption process of fluoride using one of these novel adsorbents, known an Uio-66, was optimized using a central composite design. As-synthesized Uio-66 was characterized by XRD, FT-IR spectra, FE-SEM, EDX, and BET surface area. Furthermore, the variables of fluoride concentration, pH, adsorbent dose, and contact time were investigated. The findings showed that the maximum capacity of Uio-66 for fluoride adsorption was 31.09 mg g(-1). The experimental data of Uio-66 fitted well with the pseudo-second order model and the Langmuir I model. The findings also showed that Uio-66 adsorbent has a high capacity for fluoride adsorption and can be functionalized to enhance the adsorption capacity.