(WO201948989) Novel fungicidal heterocyclic compounds 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(WO201948989) Novel fungicidal heterocyclic compounds
公开号/公开日
WO2019/048989 / 2019-03-14
申请号/申请日
WOIB2018/056581 / 2018-08-29
发明人
SHANBHAG GAJANANSHARMA ADITYAKALE YUVRAJ NAVANATHRENUGADEVI GPABBA JAGADISHPRABHAKAR SINGARABOENAMEHTA MOHAN LALS P MOHAN KUMARBELKAR YOGESH KASHIRAMAUTKAR SANTOSH SHRIDHARGARG RUCHIVENKATESHA HAGALAVADI MKLAUSENER ALEXANDER GUENTHER MARIA;
申请人
PI INDUSTRY;
主分类号
IPC分类号
A01N-043/80 A01P-003/00 C07D-417/04 C07D-417/12 C07D-417/14
摘要
(WO2019/048989) The present invention relates to a compound selected from Formula I and a process for preparing same, wherein R2, T, L1, A, G, J, n, W, Z and Z1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of Formula I.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(WO201948989) GARG, Vidisha et al. ([IN])
代理机构
;
优先权号
2017IN-11031859
主权利要求
(WO2019/048989) 1. I . A compound selected from Formula 1,   T is selected from 5- or 6-membered aryl ring or 5- or 6-membered saturated or partially saturated cyclic ring or 5- or 6-membered heteroaryl ring or 5- or 6-membered saturated or partially saturated heterocyclic ring, wherein each ring member of heteroaryl ring is selected from C, N, O and S, and wherein each ring member of heterocyclic ring is selected from C, N, O, S(0)a, C=0, C=S, S=NR6and SfOy^NR6, and T is optionally substituted by one or more Rlaon carbon ring members and one or more Rl bon heteroatom ring members;   L1is O, S, NR23,   wherein, R23is selected from hydrogen, CrC6alkyl, C2-C6alkenyl, C2-C6alkynyl, CrC6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, CrC6alkoxy C C6alkyl, CrC6alkylthio C ,-C6alkyl, CrC5alkylsulfinyl C,-C6alkyl, C,-C6alkylsulfonyl C,-C6alkyl, Ci-C6alkylcarbonyl, C ,-C6haloalkylcarbonyl, CrC6alkoxycarbonyl, CrC6alkoxycarbonyl CrC6alkyl, C C6alkylaminocarbonyl, C C6dialkylaminocarbonyl, C C6alkylsulfonyl and C C6haloalkylsulfonyl;   A is C(R15)2or C(R15)2-C(RI 5)2;   wherein, R15is independently selected from hydrogen, halogen, cyano, hydroxy, aldehyde, CrC6alkyl, C2-C6alkenyl, C2-C6alkynyl, CrC6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, CrC6alkoxy C ]-C6alkyl, CpQ alkylthio CrC6alkyl, CrC6alkylsulfinyl CrC6alkyl, C,-C6alkylsulfonyl CrC6alkyl, C C6alkylcarbonyl, CrC6haloalkylcarbonyl, C ,-C6alkoxycarbonyl, CrC6alkoxycarbonyl C i-C6alkyl, C ,-C6alkylaminocarbonyl, CrC6dialkylaminocarbonyl, CrC6alkoxy, CrC6haloalkoxy, C C6alkylthio, C C6haloalkylthio, C C6alkylsulfinyl, CrC6haloalkylsulfinyl, C C6alkylsulfonyl and C ,-C6haloalkylsulfonyl ;   W is O or S;   Z is C or N; the presentation " " in ring D is a single bond when Z is N and is a single or double bond when Z is C;  "n" is an integer ranging from 0 to 9 with the proviso that when Z is N, "n" is an integer ranging from 0 to 8; and when the presentation " " in ring D is a double bond then "n" is an integer ranging from 0 to 7;   G is an optionally substituted 5- or 6-membered heteroaryl ring or 5- or 6-membered saturated or partially saturated heterocyclic ring, each ring member of the heteroaryl ring is selected from C, N, O and S; and each ring member of the heterocyclic ring is selected from C, N, O, S(0)a, C(=0), C(=S), S(=NR6) and S(0)=NR6; wherein, carbon ring members are substituted with one or more R¾and heteroatom ring members are substituted with one or more Rl l a;   wherein,   Rais hydrogen or R3b; R3bis C ,-C3alkyl, CrC3haloalkyl, halogen, a phenyl or 5- or 6- membered heteroaromatic ring, wherein the phenyl or the 5- or 6-membered heteroaromatic ring is optionally substituted with one or more substituent independently selected from R4aon carbon ring members and R4bon nitrogen ring members,   R4ais independently selected from C>-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3- C6cycloalkyl, C3-C6cycloalkyl C|-C6alkyl, CrC<; alkyl C3-C6cycloalkyl, C C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, CrC4alkoxy, CrC4haloalkoxy, C C6aikylthio, CrC6 alkylsulfinyl, CrC6alkylsulfonyl, CrC6haloalkylthio, CrC6haloalkylsulfinyl, C,-C6haloalkylsulfonyi, CrC6alkylamino, C,-C6dialkylamino, C3-C6cycloalkylamino, Cj-C6alkoxy C|-C6alkyl, CrC6hydroxyalkyl, C C6alkylcarbonyl, C| -C6alkoxycarbonyl, CrC6alkylcarbonyloxy, CrC6alkylcarbonylthio, CrC6alkylaminocarbonyl, Cj-C6dialkylaminocarbonyl and C|-C6trialkylsilyl,   R4bis independently selected from C ,-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3- C()cycloalkyl, C |-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3- C6halocycloalkyl and CrC6alkoxy CrC6alkyl,   R "'1is hydrogen or R, lb, wherein the Rl i bis independently selected from CrC3alkyl, C3- C6cycloalkyl, C C6haloalkyl, C3-C6halocycloalkyl; J is a 5-, 6- or 7- membered carbocylic or heterocyclic ring, a 8- to 11-membered carbocylic or heterocyclic bicyclic ring system or a 7- to 11-membered carbocyclic or heterocyclic spirocyclic ring system, each ring member of the heterocyclic ring or ring system is selected from C, N, O, S(0)a, C(=0), C(=S), and each ring or ring system is optionally substituted with one or more substituents independently selected from R5, or   O R5S R5?-N— - C- - --J-N—C^-  - II I , 11 1 c ' II i II ^  J is selected from -^C—N-i1-)-^C—N-?-JR5O , R5S ,   -t-CmC — -W1-i^and- -Wc==c_t- wherein W' is C(R5)2or CO or O or S or SO or S02or NR5,   Rsis independently selected from hydrogen, halogen, cyano, hydroxy, nitro, aldehyde, carboxylic acid, CrC6alkyl, C2-C6alkenyl, C2-C6alkynyl, C C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6cycloalkyl, C3-C6halocycloalkyl, Cj-C6alkyl C3-C6cycloalkyl, C3-C6cycloalkyl C,-C6alkyl, C3-C6cycloalkyl C3-C6cycloalkyl, C3-C6halocyclo CrC6alkyl, C3-C6cycloalkenyl, C3-C6halocycloalkenyl, C,-C6alkoxy CrC6alkyl, C3-C6cycloalkoxy C C6alkyl, CrC6alkylthio CrC6alkyl, CrC6alkylsulfinyl CrC6alkyl, Cj-C6alkylsulfonyl C,-C6alkyl, CrC6alkylamino C C6alkyl, C]-C6dialkylamino CrC6alkyl, CrC6haloalkylamino Cj-C6alkyl, CrC6cycloalkylamino CrC6alkyl, CrC6alkylcarbonyl, C C6haloalkylcarbonyl, C3-C6cycloalkylcarbonyl, CrC6alkoxycarbonyl, C3-C6cycloalkoxycarbonyl, C3-C6cycloalkyl C,-C6alkoxycarbonyl, CrC6alkylaminocarbonyl, CrC6dialkylarninocarbonyl, C3-C6cycloalkylaminocarbonyl, CrC6haloalkoxy C,-C6alkyl, C C6hydroxyalkyl, C]-C6alkoxy, C C6haloalkoxy, C3-Q, cycloalkoxy, C3-C6halocycloalkoxy, C3-C6cycloalkyl CrC6alkoxy, C2-C6alkenyloxy, C2-C6haloalkenyloxy, C2-C6alkynyloxy, C2-C6haloalkynyloxy, CrC6alkoxy CrC6alkoxy, C C6alkylcarbonyloxy, Ci-C6haloalkylcarbonyloxy, C3-C6cycloalkylcarbonyloxy, CrC6alkylcarbonyl C,-C6alkoxy, C C6alkylthio, CrC6haloalkylthio, C3-C6cycloalkylthio, C|-C6alkylsulfinyl, C|-C6haloalkylsulfinyl, C C6alkylsulfonyl, CrC6haloalkylsulfonyl, C3-C6cycloalkylsulfonyl, Ci-C6trialkylsilyl, CrC6alkylsulfonylamino, CrC6haloalkylsulfonylamino or -Z2Q, wherein, Z' and Z2are independently a direct bond, O, C=0, C=S, S(0)a, CHR20o NR21; wherein, R is independently selected from hydrogen, C |-C4alkyl or CrC| haloalkyl; and R21is independently selected from hydrogen, CrC8alkyl, CrC8haloalkyl, C3-C8cycloalkyl, CrC6alkylcarbonyl, C C8haloalkylcarbonyl, CrC8alkoxycarbonyl or C C8haloalkoxycarbonyl. Q is independently selected from phenyl, benzyl, naphthyl, a 5- or 6-membered aryl ring, an 8- to 1 1 -membered aryl multi-cyclic ring system, an 8- to 1 1 - membered aryl fused ring system, a 5- or 6-membered heteroaryl ring, an 8- to 1 1 -membered heteroaryl multi-cyclic ring system or an 8- to 1 1 -membered heteroaryl fused ring system, each ring member of the ring or the ring system is selected from C, N, O and S, and each ring or ring system is optionally substituted with one or more substituents independently selected from R7on carbon atom ring members and R12on hetero atom ring members, or   Q is independently selected from a 3- to 7-membered nonaromatic carbocyclic ring, a 5-, 6- or 7-membered nonaromatic heterocyclic ring, an 8- to 15- membered nonaromatic multi-cyclic ring system or an 8- to 1 5-membered nonaromatic fused ring system, each ring member of the ring or the ring system is selected from C, N, O, S(0)„ C(=0), C(=S), S(=NR6) and S(=0)=NR6& SiR16R17, and each ring or ring system is optionally substituted with one or more substituents independently selected from R7on carbon atom ring members and R12on hetero atom ring members; or   J & Q together form a frag wherein, x in the fragments M l and M2 is an integer ranging from 0 to 2 and Y is selected from N, O and S,   wherein, Rla, Ri b, R7and R12are independently selected from from hydrogen, halogen, hydroxy, cyano, nitro, CrC6alkyl, C2-C6alkenyl, C2-C6alkynyl, CrC6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C8cycloalkyl, C3-C8halocycloalkyl, CrC6alkyl C3-C8cycloalkyl, C3-C8cycloalkyl C C6alkyl, C3-C8cycloalkyl C3-C8cycloalkyl, C3-C8halocycloalkyl C , -C6alkyl, C C6alkoxy C C6alkyl, C3-C8cycloalkoxy CrC6alkyl, CrC6alkylthio CrC6alkyl, CrC6alkylsulfmyl C C6alkyl, C |-C6alkylsulfonyl CrC(, alkyl, C|-C6alkylamino, CrC6dialkylamino, CrC6alkylamino CrC6alkyl, C C6dialkylamino C C6alkyl, CrC6haloalkylamino CrC6alkyl, C3-C8cycloalkylamino, C3-C8cycloalkylamino CrC6alkyl, C,-C6alkylcarbonyl, C C6haloalkylcarbonyl, C3-C8cycloalkylcarbonyl, CrC6alkoxycarbonyl, C3-C8cycloalkoxycarbonyl, CrC6alkylaminocarbonyl, C C6dialkylaminocarbonyl, C3-C8cycloalkylaminocarbonyl, C)-C6haloalkoxy CrC6alkyl, CrC6hydroxyalkyl, C C6hydroxyalkenyl, C,-C6hydroxyalkynyl, C]-C6alkoxy, Ci-C6haloalkoxy, C,-C6cycloalkoxy, C3-C8halocycloalkoxy, C3-C8cycloalkyl C C6alkoxy, C2-C6alkenyloxy, C2-C6haloalkenyloxy, C2-C6alkynyloxy, C2-C6haloalkynyloxy, CrC6alkoxy C C6alkoxy, CrC6alkylcarbonyloxy, C,-Cchaloalkylcarbonyloxy, C3-C6cycloalkylcarbonyloxy, CrC6alkylcarbonyl C C6alkoxy, CrC6alkylthio, CrC6haloalkylthio, C3-C8cycloalkylthio, C,-C6alkylsulfinyl, C C6haloalkylsulfinyl, CrC6alkylsulfonyl, C,-C6haloalkylsulfonyl, C3-C8cycloalkylsulfonyl, C3-C8cycloalkylsulfinyl, C,-C6trialkylsilyl, CrC6alkylsulfonylamino, CrC6haloalkylsulfonylamino, C|-C6alkylcarbonylthio, CrC6alkylsulfonyloxy, C C6alkylsulfinyloxy, arylsulfonyloxy, arylsulfinyloxy, arylsulfonyl, arylsulfinyl, CrC6cyanoalkyl, C2-C6alkenylcarbonyloxy, C,-C6alkoxy C C6alkylthio, CrC6alkylthio CrC6alkoxy, C2-C6haloalkenylcarbonyloxy, Ci-C6alkoxy C2-C6alkynyl, C2-C6alkynylthio, C3-C8halocycloalkylcarbonyloxy, C2-C6alkenylamino, C2-C6alkynylamino, CrC6haloalkylamino, C3-C8cycloalkyl C C6alkylamino, CrC6alkoxyamino, C C6haloalkoxyamino, C C6alkylcarbonylamino, C C6haloalkylcarbonylamino, Ci-C6alkoxycarbonylamino, C -C6alkenylthio, C,-C6haloalkoxycarbonyl, CrC6alkoxy Ci-C6alkylcarbonyl, CrC6haloalkoxycarbonylamino, C C6alkoxy C,-C6alkylaminocarbonyl, CrC6alkylthiocarbonyl, C3-C8cycloalkenyloxy CrC6alkyl, CrC6alkoxy C C6alkoxycarbonyl, CrC6haloalkoxy CrC6haloalkoxy, CrC6alkoxy C C6haloalkoxy, C3-C8halocycloalkoxy Ci-C6alkyl, CrC6dialkylaminocarbonylamino, CrC6alkoxy C2-C6alkenyl, CrC6alkylthiocarbonyloxy, CrC6haloalkoxy C C6alkoxy, C C6haloalkylsulfonyloxy, C C6alkoxy CrC6haloalkyl, C|-C6dihaloalkylamino, Cj-C6dialkoxy CrC6alkyl, CrC6alkylaminocarbonylamino, CrC6haloalkoxy C C6haloalkyl, C C6alkylaminocarbonyl CrC6alkylamino, C C6trialkylsilyl C2-C6alkynyloxy, C|-C6trialkyIsilyloxy, C,-C6trialkylsilyl C2-C6alkynyl, CrC6cyanoalkoxy C C6alkyl, C C6dialkylthio C C6alkyl, CrC6alkoxysulfonyl, C -C8halocycloalkoxycarbonyl, CrC6alkylcy C3-C8cloalkylcarbonyl, C3-C8halocyclo C|-C6alkylcarbonyl, C2-C6alkenyloxycarbonyl, C2-C6alkynyloxycarbonyl, CrC6cyanoalkoxycarbonyl, C,-C6alkylthio C C6alkoxycarbonyl, C2-C6alkynylcarbonyloxy, C2-C6haloalkynylcarbonyloxy, cyanocarbonyioxy, CrC6cyanoalkylcarbonyloxy, C3-C8cycloalkylsulphonyloxy, C3-C8cycloalkyl CrC6alkylsulphonyloxy, C3-C8halocycloalkylsulphonyloxy, C2-C6alkenylsulphonyloxy, C2-C6alkynylsulphonyloxy, C C6cyanoalkylsulphonyloxy, C2-C6haloalkenylsulphonyloxy, C2-C6haloalkynylsulphonyloxy, C2-C6alkynyicycloalkyloxy, C2-C6cyanoalkenyloxy, C2-C6cyanoalkynyloxy, C C6alkoxycarbonyloxy, C2-C6alkenyloxycarbonyloxy, C2-C6alkynyloxycarbonyloxy, CrC6alkoxyalkylcarbonyloxy, sulfilimines, sulfoximines, SF5or Z2Q,   Ri f' and R17are independently selected from C C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-Q cycloalkyl, C3-C6halocycloalkyl, CrC6cycloalkyl CpQ, alkyl, CrC6alkyl C3-C6cycloalkyl, C C6haloalkyl, C C<, alkoxy and CrC(, haloalkoxy,   R5and R7or R5and R12taken together with the atoms linking R5and R7or R12to form a saturated, unsaturated or partially unsaturated 4- to 7- membered ring, each ring members selected from C, N, O, S(0)a,C=0, C=S, S=NR6and S(0)=NR6, and said ring optionally substituted on ring members other than the atoms linking R5and R7or R12with R8, wherein, R8is selected from halogen, C]-C6alkyl, CrC6haloalkyl, C -C8cycloalkyl, and C3-Cg cycloalkyl;   R2and R6are independently selected from hydrogen, halogen, cyano, hydroxy, aldehyde, carboxylic acid, C C6alkyl, C2-C6alkenyl, C -C6alkynyl, C C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6cycloalkyl, C3-C6halocycloalkyl, C C6alkyl C3-C6cycloalkyl, C3-C6cycloalkyl CpQ alkyl, C3-C(, halocycloalkyl CrC6alkyl, C -Q cycloalkenyl, C3-C halocycloalkenyl, CrC6alkoxy C |-C6alkyl, C,-C6alkylthio CrC6alkyl, CrC6alkylsulfinyl CrC6alkyl, Cj-C6alkylsulfonyl C|-C6alkyl, CrC6alkylamino Ci-C6alkyl, CpQ dialkylamino CrC6alkyl, C C6haloalkylamino Ci-C6alkyl, C ]-C6alkylcarbonyl, CrC6haloalkylcarbonyl, C3-C6cycloalkylcarbonyl, C C6alkoxycarbonyl, C3-C6cycloalkoxycarbonyl, C3-C6cycloalkyl Ci-C6alkoxycarbonyl, CrC6alkylaminocarbonyl, C,-C6dialkylaminocarbonyl, CrC6alkoxy, CrC6haloalkoxy, C3-C6cycloalkoxy, C3-C6halocycloalkoxy, C2-C6alkenyloxy, C2-C6haloalkenyloxy, C2-C6alkynyloxy, C2-C6haloalkynyloxy, CrC6alkoxy CrC6alkoxy, CrC6alkylcarbonyloxy, C C6haloalkylcarbonyloxy, C C6alkylthio, CrC6haloalkylthio, C3-C6cycloalkylthio, CrC6alkylamino, C C6dialkylamino, C i-C6haloalkylamino, C |-C6halodialkylamino, C3-C6cycloalkylamino, CrC6alkylcarbonylamino, CrC()haloalkylcarbonylamino, C C6alkylsulfonylamino and CrC6haloalkylsulfonylamino, or   two R2are taken together as CrC4alkylene or C2-C4alkenylene or -CH=CH-CH=CH- to form a bridged bicyclic or fused bicycl ic ring system optional ly substituted with a substituent selected from C i-Q alkyl, CrC6haloalkyl, CrC6alkoxy, CrC6haloalkoxy, halogen, hydroxy, amino cyano and nitro,   proviso that the compounds are excluded from the definition of Formula 1:   Ethanone, 1 -[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2-thiazolyl]-l -piperidinyl]-2-[[5- (trifluoromethyl)-2-pyridinyl]thio]- (CAS RN- 1023141 -80-1 );   Benzamide, 2-[[2-[4-[4-[3-(3,4-dichlorophenyl)-5-isoxazolyl]-2-thiazolyl]- l -piperidinyl]- 2-oxoethyl]thio]-4-ethoxy- (CAS RN- 1 177816-84-0);   Ethanone, 2-[(2-chloro-4-fluorophenyl)thio]- l -[4-[4-[3-(3,4-dichlorophenyl)-5- isoxazolyl]-2-thiazolyl]- l -piperidinyl]- (CAS RN- 1 177683-42-9);   Ethanone, 2-(cyclohexyloxy)- l -[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]- 2-thiazolyl]- l -piperidinyl]- (CAS RN- 1 173972-38-7);   1 -Propanone, 2-(4-chlorophenoxy)-2-methyl- l -[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2- thiazolyl]- l -piperidinyl]- (CAS RN- 1 136418-28-4);   Ethanone, 2-[(2-chloro-4-fluorophenyl)thio]- l -[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2- thiazolyl]-! -piperidinyl]- (CAS RN- 1 023 177-70-9);   Benzenesulfonamide, N-methyl-2-[[2-[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2- thiazolyl]-l -piperidinyl]-2-oxoethyl]thio]- (CAS RN- 1023156-55-9);   Benzenesulfonamide, 2-[[2-[4-[4-[3-(3,4-dichlorophenyl)-5-isoxazolyl]-2-thiazolyl]-l - piperidinyl]-2-oxoethyl]thio]-N-methyl- (CAS RN- 1022602-51 -2);   Ethanone, l -[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2-thiazolyl]-l -piperidinyl]-2- (2,3,4,5,6-pentafluorophenoxy)- (CAS RN- 1022567-65-2);   Ethanone, l -[4-[4-[3-(3,4-dichlorophenyl)-5-isoxazolyl]-2-thiazolyl]- l -piperidinyl]-2- [(4-methylphenyl)sulfonyl]- (CAS RN- 1 022566-90-0);   Ethanone, 2-(2,4-dichlorophenoxy)- l -[4-[4-[3-(3,4-dichlorophenyl)-5-isoxazolyl]-2- thiazolyl]- ] -piperidinyl]- (CAS RN- 1022328-76-2);   Ethanone, 2-(2,4-dichlorophenoxy)- l -[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2- thiazolyl]- l -piperidinyl]- (CAS RN- 1022068-84-3);   Ethanone, l -[4-[4-[3-(3,4-dichlorophenyl)-5-isoxazolyl]-2-thiazolyl]- l -piperidinyl]-2- (2,3,4,5,6-pentafluorophenoxy)- (CAS RN- 1022028-25-6);   1 -Propanone, l -[4-[4-(5-methyl-3-phenyl-4-isoxazolyl)-2-thiazolyl]- l -piperidinyl]-3-[(2- methylphenyl)thio]- (CAS RN- 1022326-33-5); and   1 -Propanone, l -[4-[4-[3-(3,4-dichlorophenyl)-5-isoxazolyl]-2-thiazolyl]- l -piperidinyl]-3- [(2-methylphenyl)thio]- (CAS RN 1024410- 18- 1 ),   the salts, isomers, metal complexes, N-oxides and polymorphs thereof. The compound as claimed in claim 1, wherein,   L1is O, S or NH;   A is C(RI5)2;   W isO;   Z is C;   the presentation " " in ring D is a single bond;  "n" is an integer ranging from 0 to 9;   G is an optionally substituted 5-membered heteroaryl;   J is a 5- membered heterocyclic ring, wherein heteroatom ring members are selected from N and O; R5is Z2Q;   Z' and Z2are a direct bond; and   Q is phenyl or 6-membered heteroaryl ring; or   J and Q together form a fragment selected from Μ or M2'   M1' M2'   R5and R7each has the same meaning as defined in the claim 1.   The compound as claimed in claim 1, wherein,   T is Tl to T47;   G isGl to G63;   J is Jl to J82; and   QisQl to Q99.   The compound as claimed in claim 1, wherein,   T is selected from Til, T25, T26, T37, T38, and T39;   G is selected from Gl, G15, G37, G45, G61;   J is selected from J30, Jl 1 and J29; and   Q is Q45, Q32, Q33, Q34, Q36, Q38 and Q39.  The compound as claimed in claim 1, comprising   l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((l- methyl- 1 H-pyrazol-3-yl)oxy)ethan-l -one; l-(4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazoI-3 yl)thiazol-2-yl)piperidin-l-yl)-2-((l-methyl-3-(trifluoi methyl)-lH-pyrazol-5-yl)oxy)ethan-l- one; l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yI)thiazol-2-yl)piperidin-l-yl)-2-((l methyl-3-(trifluoromethyl)-lH-pyrazol-5-yl)oxy)ethan-l-one; 3-chIoro-2-(3-(2-(l-(2-((] -methyl- 3-(trif]uoromethyl)-lH-pyrazol-5-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yI)-4,5-dihydroisoxazol- 5-yl)phenylmethanesulfonate; 3-chloro-2-(3-(2-(l-(2-((l-methyl-lH-pyrazol-3- yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5-yl)phenylmethanesulfonate; 1- (4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazo]-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((5- (difluoromethyl)-l -methyl- lH-pyrazol-3-yl)oxy)ethan-l -one; 2-((5-(difluoromethyl)-l-methyl- lH-pyrazol-3-yl)oxy)-l-(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2- yl)piperidin-l-yl)ethan-l-one; 3-chloro-2-(3-(2-(l-(2-((5-(difluoromethyl)-l-methyl-lH-pyrazol- 3-yl)oxy)acety!)piperidin-4-yl)thiazol-4-yl)-4,5-dihydiOisoxazoi-5-yl)phenylmethanesulfonate 2- ((5-(difluoromethyl)-l-methyl-lH-pyrazol-3-y])oxy)-l-(4-(4-(5-(2,6-difluorophenyl)-4,5- dihydroisoxazo]-3-yl)thiazol-2-y])piperidin-]-yl)ethan-l-one; 2-((l-methyl-3-(trifluoromethyl)- lH-pyrazol-5-yl)oxy)-l-(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2- yl)piperidin-l-yl)ethan-l-one; 2-((4-bromo-l-methyl-5-(trifluoromethyl)-lH-pyrazol-3-yl)oxy)-  1- (4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yI)thiazol-2-y!)piperidin-l-yl)ethan-l-o  2- (3-(2-(l-(2-((4-bromo-l-methyl-5-(trifluorornethyl)-lH-pyrazol-3-yl)oxy)acetyl)piperidin-4- yl)thiazol-4-yl)-4,5-dihydroisoxazol-5-yl)-3-chlorophenylmethanesuIfonate; 2-((4-bromo-l- methyl-5-(trifluoromethyl)-lH-pyrazol-3-yl)oxy)-l-(4-(4-(5-(2,4,6-trichlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-((4-bromo-l-methyl-5- (trifluoromethyl)-lH-pyrazol-3-yl)oxy)-l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3- yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; l-(4-(4-(5-(2,6-dichIorophenyl)-4,5-dihydroisoxazol-  3- yl)thiazol-2-yl)piperidin-l-yl)-2-((l-methyl-5-(trifluoromethyl)-lH-pyrazol-3-yl)oxy)ethan-l- one; 2-((4-bromo-l-methyl-3-(trifluoromethyl)-lH-pyrazol-5-yl)oxy)-l-(4-(4-(5-(2,6- dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yI)piperidin-l-yl)ethan-l-one; 2-(3-(2-(l-(2- ((4-bromo-l-methyl-3-(trifluoromethyl)-lH-pyrazol-5-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)- 4,5-dihydi isoxazol-5-yl)-3-chIorophenylmethanesulfonate; 2-((4-bi mo-I-methyI-3- (trifluoromethyl)-lH-pyrazol-5-yl)oxy)-l-(4~(4-(5-(2,6-difluoi phenyl)-4,5-dihydiOisoxazol-3- ■y])thiazol-2-yl)piperidin-l-yl)ethan-1-one; 3-chloro-2-(3-(2-(l-(2-((l-methyl-5-(trifluoromethy])- lH-pyrazol-3-yl)oxy)acetyl)piperidin-4-y])thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesulfonate; l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazoI-3-y])thiazol-2- yl)piperidin-l-yl)-2-((l-methyl-5-(tnfluorornethyl)-lH-pyrazol-3-yl)oxy)ethan-l-one; 2-((l- methyl-5-(trifluoroiTiethyl)-lH-pyrazol-3-yl)oxy)-l-(4-(4-(5-(2,4,6-trichloi phenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-((4-bromo-l-methyl-3- (trifluot methyl)-lH-pyrazol-5-yl)oxy)-l-(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3- yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-(2, 4-dich!orophenoxy)-l-(4-(4-(5-(2,6- dich!orophenyl)-4,5-dihydiOisoxazo!-3-y])thiazol-2-yl)piperidin-l-yl)pi pan-l-one; 3-ch!oro-2- (3-(2-(l-(2-(2,4-dichloiOphenoxy)pi panoy])piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesulfonate; 2-(2,4-dichlorophenoxy)-l -(4-(4-(5-(2,4,6-trichlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)pi pan-l-one; 2-(2,4-dichlorophenoxy)-l -(4-(4- (5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)propan-l-one; l-(4- (4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazo]-2-yl)pipendin-l-yl)-2-((3- (trifluoromethyl)pyridin-2-yl)oxy)ethan-l-one; 3-chloro-2-(3-(2-(l-(2-((3- (trifluoromethyI)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesulfonate; l-(4-(4-(5-(2,6-difluoi phenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2- yl)piperidin-l-yI)-2-((3-(tnfluoromethyl)pyridin-2-yl)oxy)ethan-l-one; l-(4-(4-(5-(2,4,6- trich]orophenyl)-4,5-dihydiOisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((3- (trifluoromethyl)pyridin-2-y])oxy)ethan-l-one; 2-((5-chloiO-3-(trifluoromethyl)pyridin-2-yl)oxy)-  1- (4-(4-(5-(2,6-dich]orophenyl)-4,5-dihydroisoxazol-3-yl)thiazo]-2-yl)piperidin-l-yl)ethan-l-one; 3-chloiO-2-(3-(2-( I -(2-((5-chloro-3-^   yl)thiazol-4-yl)-4,5-dihydroisoxazol-5-yl)phenylmethanesulfonate; 2-((5-chloro-3- (trifluoromethyl)pyridin-2-yl)oxy)-l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3- yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-((5-chloro-3-(trifluoromethyl)pyridin-2-yl)oxy)-l - (4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one;  2- ((5-brorno-3-(trifluoiOmethyl)pyridin-2-yl)oxy)-l-(4-(4-(5-(2,6-dichlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazo!-2-yl)piperidin-l -yl)ethan-l -one; 2-(3-(2-(l -(2-((5-bromo-3- (trifluoromethyl)pyridin-2-yl)oxy)acetyl)piperidjn-4-yl)thiazol-4-y])-4,5-dihydroisoxazol-5-yl)-3- chlorophenylmethanesu!fonate; 2-((5-bromo-3-(trifluoromethyl)pyridin-2-yl)oxy)-l-(4-(4-(5- (2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-((5- bromo-3-(trifluoi methyl)pyridin-2-yI)oxy)-l-(4-(4-(5-(2,4,6-tnchlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-((6-methyl-3- (trifluoromethyl)pyridin-2-yl)oxy)-l-(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3- yl)thiazol-2-yl)piperidin- 1 -yl)ethan- 1 -one; 1 -(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-  3- yl)tbiazol-2-y])piperidin-]-yl)-2-((6-methyl-3-(trifiuoromethyl)pyridin-2-yl)oxy)ethan-l-one ]-(4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazo]-2-yl)piperidin-l-yl)-2-((6- methyl-3-(trifluoiOmethyi)pyridin-2-yl)oxy)ethan-l-one; 3-chloro-2-(3-(2-(l-(2-((6-methyl-3- (trifluoromethyl)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesulfonate; l-(4-(4-(5-(2,6-difluoropheny])-4,5-dihydroisoxazoI-3-yl)thiazol-2- yl)piperidin-l-yl)-2-((4-(trifluoromethyl)pyridin-2-yl)oxy)ethan-l-one; l-(4-(4-(5-(2,4,6- trichloiOphenyl)-4,5-dihydiOisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((4- (trifluoromethyl)pyridin-2-yl)oxy)ethan-l-one; l-(4-(4-(5-(2,6-dichlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l -yl)-2-((4-(trifluoromethyl)pyridin-2-yl)oxy)ethan- 1-one; 3-chloro-2-(3-(2-(l-(2-((4-(trifluoromethyl)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol- 4-yl)-4,5-dihydroisoxazol-5-yl)phenylmethanesulfonate; l-(4-(4-(5-(2,6-dichlorophenyl)-4,5- dihydi isoxazol-3-yl)thiazol-2-yl)piperidin-l-yI)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)ethan- 1-one; 3-chloro-2-(3-(2-(l-(2-((5-(trifluoromethyl)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol- 4-yI)-4, 5-dihydroisoxazol-5-yl)phenylmethanesulfonate; l-(4-(4-(5-(2,6-difluorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)pipendin-l-yl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy^ 1-one; l-(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3-yl)t iazol-2-yl)piperidin-l-yl)-2- ((5-(trifluoromethyl)pyridin-2-yl)oxy)ethan- 1-one; 2-((3-bromo-5-(trifluorotnethyl)pyridin-2- yl)oxy)-l-(4-(4-(5-(2,6-dichlorophenyI)-4,5-dihydroisoxazol-3-yl)thiazo!-2-yl)piperidin-l- yl)ethan- 1-one; 2-(3-(2-(l-(2-((3-bromo-5-(trif]uoromethyl)pyridin-2-yl)oxy)acetyl)piperidin-4- yl)thiazol-4-yl)-4,5-dihydroisoxazol-5-yl)-3-chlorophenylmethanesulfonate; 2-((3-bromo-5- (trifluoromethyl)pyridin-2-yl)oxy)-l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3- yl)thiazol-2-yl)piperidin-l-yl)ethan-l-one; 2-((3-bromo-5-(tnfluoromethyl)pyridin-2-yl)oxy)-l- (4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-y])ethan- 1-one; l-(4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((5- (tnfluoi methyl)pyridin-2-yl)thio)ethan- 1-one; 3-chloro-2-(3-(2-(l-(2-((5- (trifluoromethyl)pyridin-2-yl)thio)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesu!fonate; l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2- yl)piperidin-l-yl)-2-((5-(trifluoromethyl)pyridin-2-yl)thio)ethan- 1-one; l-(4-(4-(5-(2,4,6- trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((5- (trifluoromethyl)pyridin-2-yl)thio)ethan-l-one; l-(4-(4-(l,5-dihydrobenzo[e][l,3]dioxepin-3- yl)thiazol-2-yl)piperidin-l-yl)-2-((3-(tnfluoromethyl)pyridin-2-yl)oxy)ethan- 1-one; 3-chloro-2- (3-(2-(l-(2-((3-(trifluoromethyl)pyridin-2-yl)thio)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5- dihydroisoxazol-5-yl)phenylmethanesulfonate; 3-chloro-2-(3-(2-(l-(2-((3- (trifluoromethyl)pyridin-2-yl)thio)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesulfonate; l-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2- yl)piperidin-l-yl)-2-((3-(trifluoromethyl)pyridin-2-yl)thio)ethan- 1-one; l-(4-(4-(5-(2,4,6- trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((3- (trifluoromethyl)pyridin-2-yl)thio)ethan- 1-one; l-(4-(4-(5-(3-(trifluoromethyl)phenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-2-((3-(trifluoromethyl)pyridin-2-yl)oxy)ethan- 1-one; 2-((3-chIoro-5-(trifluoromethyl)pyridin-2-yl)thio)-l-(4-(4-(5-(2,6-dif1uorophenyl)-4,5- dihydroisoxazol-3-yl)thiazoI-2-yl)piperidin-l-yl)ethan- 1-one; l-(4-(4-(5-(2-fluorophenyl)-4,5- dihydroisoxazol-3-yl)thiazoI-2-yl)piperidin- l -yl)-2-((3-(trifluoromethyl)pyridin-2-yl)oxy)eth 1 -one; 2-((5-chloro-3-(trifluoromethyI)pyridin-2-yl)oxy)- l -(4-(4-(5-(4-methoxyphenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- ] -yl)ethan-l -one; 2-((3-chloro-5- (trifluoromethy])pyridin-2-yl)thio)- l -(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3- yI)thiazol-2-yl)piperidin- l -yl)ethan- l -one; N-(((2-(4-(4-(5-(2,6-difluorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- l -yl)-2-oxoethyl)(5-(trifluoromethyl)pyridin-2- yl)amino)(dimethylamino)methy]ene)-N-methylmethanaminium; l -(4-(4-(5-(2,6- dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- l -yl)-2-((6- (trifluoromethyl)pyridin-2-yl)oxy)ethan- 1 -one; 3-chloro-2-(3-(2-( l -(2-((6- (trifluoromethyl)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5- yl)phenylmethanesulfonate; l -(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2- yl)piperidin-l -yl)-2-((6-(trifluoromethyl)pyridin-2-yl)oxy)ethan- 1 -one; l -(4-(4-(5-(2, 4,6- trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- l -yl)-2-((6- (trifluoromethyl)pyridin-2-yl)oxy)ethan-l -one; 2-((3-chloro-5-(trifluoromethyl)pyridin-2- yl)thio)-l -(4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l - yl)ethan- 1 -one; l -(4-(4-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-  1 - yl)-2-((5-(trifluoromethyl)pyridin-2-yl)amino)ethan- 1 -one; l -(4-(4-(5-(2,6-dichlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- l -yl)-2-((3-methy]pyndin-2-yl)oxy)ethan-l -one; 1 - (4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-y])piperidin- l -yl)-2-((3- methylpyridin-2-yl)oxy)ethan-l -one; 3-chloro-2-(3-(2-( l -(2-((3-methylpyridin-2- yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazol-5-yl)phenylmethanesulfonate; 2- ((3-methylpyridin-2-yl)oxy)-l -(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-  2- yl)piperidin-l -yl)ethan-l -one; 1 -(4-(2-(5-(2,6-dichlorophenyl)-4,5-dihydroisoxazol-3- yl)pyridin-4-yl)pipei"idin-l -yl)-2-((3-(trifluoiOmethyl)pyridin-2-yl)oxy)ethan- 1 -one; 3-chloro-2- (3-(2-( l -(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yI)thio)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5- dihydroisoxazol-5-yl)phenylmethanesulfonate; l -(4-(4-(5-(2,6-dichlorophenyl)-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- 1 -yl)-2-((3-(trifluoromethyl)pyridin-2- .   yl)amino)ethan- 1 -one; 2-((5-methyl-3-(trifluoromethyl)pyridin-2-yl)oxy)- l -(4-(4-(5-(2,4,6- trichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l -yl)ethan- 1 -one; l -(4-(4-(5- (2,6-dichlorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l -yl)-2-((5-methyI-3- (trifluoi methyl)pyridin-2-yl)oxy)ethan- 1 -one; 3-chloro-2-(3-(2-( l -(2-((5-methyl-3- (trifluoromethyl)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)-4,5-dihydi isoxazol-5- yl)phenyImethanesulfonate; 2-((3-(difluoromethyl)pyridin-2-yl)oxy)- l -(4-(4-(5-(2,6- difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin- l -yl)ethan- 1 -one; 2-((3- (difluoromethyl)pyridin-2-yl)oxy)- 1 -(4-(4-(5-(2,4,6-trichlorophenyl)-4,5-dihydroisoxazoI-3- yl)thiazol-2-yl)piperidin- l -yl)ethan- l -one; l -(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazoi- 3-yl)thiazol-2-yl)piperidin-l -yl)-2-((5-methyl-3-(^   3-chloro-2-(3-(2-( l -(2-((3-(difluoromethyI)pyridin-2-yl)oxy)acetyl)piperidin-4-yl)thiazol-4-yl)^ 4,5-dihydroisoxazol-5-yl)phenylmethanesulfonate; l -(4-(4-(5-(2,6-(...)
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