Multiple oligonucleotide moieties on peptide carrier 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2015179742 A1 2015-11-26 [WO2015179742] / 2015-11-26
申请号/申请日
2015WO-US32142 / 2015-05-22
发明人
WEEDEN TIMOTHY E;NELSON CAROL A;WENTWORTH BRUCE M;CLAYTON NICHOLAS P;LEGER ANDREW;
申请人
GENZYME;
主分类号
IPC分类号
A61K-031/712A61K-047/48C07K-019/00C12N-015/113
摘要
(WO2015179742) The present disclosure relates to antisense oligonucleotides (AONs), such as phosphorodiamidate morpholino oligonucleotides (PMOs).  The present disclosure further relates to the conjugation of multiple PMOs to cationic cell penetrating peptides (CPPs) to enhance the uptake of PMOs into skeletal and cardiac muscle cells.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
代理机构
;
优先权号
2014US-62002296 2014-05-23
主权利要求
(WO2015179742)  1 . A peptide conjugated AON compound comprising at least two AON compounds comprising from 15 to 30 subunits of Formulas (I), (II), (I II), (IV), (V), or (VI): wherein B is a naturally occurring purine or pyrimidine nucleotide base selected from C, G, A, or T; wherein said at least two AON compounds have a nucleotide base sequence that is complementary to at least 75% of the bases of a target pre-mRNA or mRNA; wherein said at least two AON compounds have from 0 to 3 repeating subunits where B is G; wherein said at least two AON compounds have less than 60% of said subunits where B is C or G; wherein said at least two AON compounds have a non-self- complimentary sequence; and wherein said at least two AON compounds are conjugated to a polycationic peptide.  2. A peptide conjugated phosphorodiamidate morpholino compound comprising at least two phosphorodiamidate morpholino compounds comprising from 15 to 30 subunits of Formula (I): R2N (I) wherein R is an alkyl group and B is a naturally occurring purine or pyrimidine nucleotide base selected from C, G, A, or T; wherein said at least two phosphorodiamidate morpholino compounds have a nucleotide base sequence that is complementary to at least 8 contiguous bases of a target pre-mRNA or mRNA; wherein said at least two phosphorodiamidate morpholino compounds have from 0 to 3 repeating subunits where B is G; wherein said at least two phosphorodiamidate morpholino compounds have less than 60% of said subunits where B is C or G; wherein said at least two phosphorodiamidate morpholino compounds have a non-self-complimentary sequence; and wherein said at least two phosphorodiamidate morpholino compounds are conjugated to a polycationic peptide.
法律状态
(WO2015179742) LEGAL DETAILS FOR WO2015179742  Actual or expected expiration date=2017-11-23    Legal state=ALIVE    Status=PENDING     Event publication date=2015-05-22  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOUS2015032142  Application date=2015-05-22  Standardized application number=2015WO-US32142     Event publication date=2015-11-26  Event code=WO/A1  Event type=Examination events  Published application with search report  Publication country=WO  Publication number=WO2015179742  Publication stage Code=A1  Publication date=2015-11-26  Standardized publication number=WO2015179742  LEGAL DETAILS FOR DESIGNATED STATE AU2015263963  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=AU Corresponding appl: AU2015263963  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2015AU-0263963 Corresponding cc:  Designated or member state=AU Corresponding pat: AU2015263963  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2016-12-01   Publication number in the designated or member state=AU2015263963    Event publication date=2016-12-01  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=AU  LEGAL DETAILS FOR DESIGNATED STATE BR112016027236  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=BR Corresponding appl: BR112016027236  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2016BR-0027236 Corresponding cc:  Designated or member state=BR Corresponding pat: BR112016027236  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2016-12-06   Publication number in the designated or member state=BR112016027236    Event publication date=2016-12-06  Event code=WO/REG  Event code=BR/B01A  Event type=Examination events  Reference to a national code Pct publication - request for entry into the national phase Comunicacao da publicacao internacional pct. apresentacao de peticao de requerimento de entrada na fase nacional Corresponding cc:  Designated or member state=BR  LEGAL DETAILS FOR DESIGNATED STATE CA2949104  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=CA Corresponding appl: CA2949104  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2015CA-2949104 Corresponding cc:  Designated or member state=CA Corresponding pat: CA2949104  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2015-11-26   Publication number in the designated or member state=CA2949104    Event publication date=2016-11-14  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=CA  LEGAL DETAILS FOR DESIGNATED STATE CN106459975  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=CN Corresponding appl: CN201580027369  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2015CN-80027369 Corresponding cc:  Designated or member state=CN Corresponding pat: CN106459975  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-02-22   Publication number in the designated or member state=CN106459975 LEGAL DETAILS FOR DESIGNATED STATE DE  Actual or expected expiration date=2016-11-23    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE     Event publication date=2016-11-23  Event code=WO/NENP  Event type=Event indicating Not In Force  Non-entry into the national phase in: Corresponding cc:  Designated or member state=DE  LEGAL DETAILS FOR DESIGNATED STATE EP3151841  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=EP Corresponding appl: EP15727795  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2015EP-0727795 Corresponding cc:  Designated or member state=EP Corresponding pat: EP3151841  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2017-04-12   Publication number in the designated or member state=EP3151841    Event publication date=2016-01-13  Event code=WO/121  Event type=Designated states  EP: The EPO has been informed by wipo that ep was designated in this application Corresponding cc:  Designated or member state=EP     Event publication date=2016-12-15  Event code=WO/REEP  Event indicator=Pos  Event type=Entry into national phase  Request for entry into the European phase Corresponding cc:  Designated or member state=EP  LEGAL DETAILS FOR DESIGNATED STATE IL249064  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=IL Corresponding appl: IL24906416  Application date in the designated or member state=2016-11-20   Application number in the designated or member state=2016IL-0249064 Corresponding cc:  Designated or member state=IL Corresponding pat: IL249064  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-01-31   Publication number in the designated or member state=IL-249064    Event publication date=2016-11-20  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=IL  LEGAL DETAILS FOR DESIGNATED STATE JP2017517253  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=JP Corresponding appl: JP2016567889  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2016JP-0567889 Corresponding cc:  Designated or member state=JP Corresponding pat: JP2017517253  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-06-29   Publication number in the designated or member state=JP2017517253    Event publication date=2016-11-15  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=JP  LEGAL DETAILS FOR DESIGNATED STATE KR20170005118  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=KR Corresponding appl: KR20167035607  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2016KR-7035607 Corresponding cc:  Designated or member state=KR Corresponding pat: KR20170005118  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-01-11   Publication number in the designated or member state=KR20170005118    Event publication date=2016-12-20  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=KR  LEGAL DETAILS FOR DESIGNATED STATE MX2016015156  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=MX Corresponding appl: MX2016015156  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2016MX-PA15156 Corresponding cc:  Designated or member state=MX Corresponding pat: MX2016015156  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-03-27   Publication number in the designated or member state=MX2016015156 LEGAL DETAILS FOR DESIGNATED STATE RU  Actual or expected expiration date=2034-05-23    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=RU Corresponding appl: RU2016150629    Event publication date=2016-12-23  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=RU  LEGAL DETAILS FOR DESIGNATED STATE SG11201608880V  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=SG Corresponding appl: SG11201608880V  Application date in the designated or member state=2015-05-22   Corresponding cc:  Designated or member state=SG Corresponding pat: SG11201608880V  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2016-11-29   Publication number in the designated or member state=SG11201608880V LEGAL DETAILS FOR DESIGNATED STATE US2017182171  Actual or expected expiration date=2035-05-22    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=US Corresponding appl: US15313405  Application date in the designated or member state=2015-05-22   Application number in the designated or member state=2015US-15313405 Corresponding cc:  Designated or member state=US Corresponding pat: US2017182171  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2017-06-29   Publication number in the designated or member state=US20170182171    Event publication date=2016-11-22  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=US
专利类型码
A1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部