(US10369089) Iron oxide nanoparticles and methods of use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(US10369089) Iron oxide nanoparticles and methods of use thereof
公开号/公开日
US10369089 US20180028417 / 2019-08-06 2018-02-01
申请号/申请日
US15/550,267 / 2016-02-12
发明人
KOO HYUN GAO LIZENG CORMODE DAVID NAHA PRATAP
申请人
UNIVERSITY OF PENNSYLVANIA
主分类号
IPC分类号
A01N-059/16 A61K-008/02 A61K-008/19 A61K-008/20 A61K-008/21 A61K-008/22 A61K-008/24 A61K-008/66 A61K-008/73 A61K-009/00 A61K-009/14 A61K-009/51 A61K-033/26 A61K-033/40 A61K-047/69 A61Q-011/00
摘要
(US10369089)
The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(US10369089) Baker Botts L.L.P.
代理机构
优先权号
2015US-62115968 2016US-15550267 2016WO-US17858
主权利要求
(US10369089)
The invention claimed is:
1. A method of treating an oral disease comprising: 
 (i) administering to a subject an effective amount of a composition comprising one or more iron nanoparticles; and 
 (ii) administering to the subject an effective amount of hydrogen peroxide.
2. The method of claim 1, wherein the composition further comprises a compound selected from the group consisting of fluoride, copper, calcium phosphate, sodium percarbonate and combinations thereof.
3. A method of treating an oral disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to one or more enzymes selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
4. A method of treating a biofilm-associated disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles, wherein the one or more iron nanoparticles comprise nanoparticles that have a polymeric coating.
5. The method of claim 1, wherein the hydrogen peroxide is administered in a solution that comprises hydrogen peroxide at a concentration from about 0.1% to about 3.0%.
6. A method of treating an oral disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles, wherein the concentration of the iron nanoparticles within the composition is from about 0.01 to about 10.0 mg/ml.
7. A method for the elimination and/or treatment of an oral disease comprising: 
 (i) contacting a surface having a biofilm with an effective amount of a composition comprising one or more iron nanoparticles; and 
 (ii) contacting the surface with a solution comprising hydrogen peroxide, 
 wherein the one or more iron nanoparticles and hydrogen peroxide react to form one or more radicals that eliminates and/or treats the oral disease.
8. The method of claim 1, wherein the one or more iron nanoparticles comprise nanoparticles that have a polymeric coating.
9. The method of claim 1, wherein the concentration of the iron nanoparticles within the composition is from about 0.01 to about 10.0 mg/ml.
10. The method of claim 1, wherein the one or more iron nanoparticles are doped with a metal or a salt thereof.
11. The method of claim 1, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to one or more enzymes selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
12. The method of claim 1, wherein the oral disease comprises dental caries.
13. The method of claim 7, wherein the hydrogen peroxide is administered in a solution that comprises hydrogen peroxide at a concentration from about 0.1% to about 3.0%.
14. The method of claim 7, wherein the one or more iron nanoparticles comprise nanoparticles that have a polymeric coating.
15. The method of claim 7, wherein the concentration of the iron nanoparticles within the composition is from about 0.01 to about 10.0 mg/ml.
16. The method of claim 7, wherein the one or more iron nanoparticles are doped with a metal or a salt thereof.
17. The method of claim 7, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to one or more enzymes selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
18. A method of treating a biofilm-associated disease comprising: 
 (i) administering to a subject an effective amount of a composition comprising one or more iron nanoparticles; and 
 (ii) administering hydrogen peroxide to the subject at a concentration from about 0.1% to about 3.0%.
19. The method of claim 18, wherein the hydrogen peroxide is present in the composition comprising the one or more iron nanoparticles.
20. The method of claim 18, wherein the composition further comprises a compound selected from the group consisting of fluoride, copper, calcium phosphate, sodium percarbonate and combinations thereof.
法律状态
GRANTED
专利类型码
B2 A1
国别省市代码
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