A83543 recovery process 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO9106552 A1 1991-05-16 [WO9106552] / 1991-05-16
申请号/申请日
1990WO-US06187 / 1990-10-26
发明人
BAKER PATRICK JAMES;
申请人
ELI LILLY;
主分类号
IPC分类号
A01N-043/22C07H-001/08C07H-017/08C12P-019/62C12R-001/01
摘要
(WO9106552) Improved process for recovering the useful insecticidal fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, which comprises extracting the A83543 from the whole broth into a water miscible solvent such as acetone, filtering to remove the biomass, raising the pH of the filtrate to 10-11 and extracting the A83543 with an immiscible solvent such as ethyl acetate, back extracting with an acidic solution and separating the A83543 by precipitating it with a base.
机翻摘要
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地址
代理人
代理机构
;
优先权号
1989US-07429441 1989-10-30 1989US-07451394 1989-12-15
主权利要求
(WO9106552) 1. I CLAIM: 1. A process for recovering fermentation product A83543, comprising A83543A and A83543D, which comprises: 1) adding an approximately equal volume of a water miscible solvent to the whole broth; 2) separating the liquid phase from the biomass; 3) extracting the liquid phase at a pH of about 10 to about 11 with an immiscible solvent; 4) separating the organic phase and concentrating it to remove the remaining water-miscible solvent; 5) removing the highly colored immiscible aqueous phase from the enriched organic phase; 6) back-extracting the organic phase with a dilute solution of an acid; and 7) either i) a) removing the miscible portion of the organic solvent from the aqueous acidic phase, b) concentrating the enriched aqueous phase using reverse osmosis, and c) adding a sufficient amount of a base to precipitate the A83543; or ii) adding a base which contains up to 20% acetone or methanol in a sufficient amount to precipitate the A83543; and 8) separating the A83543 by filtration. 2. A process of claim 1 wherein step 7 (i) is used. 3. A process of claim 1 wherein step 7 (ii) is used. 4. A process of claim 1 wherein the water miscible solvent in step 1 is acetone. 5. A process of claim 1 wherein the solvent used in step 3 is ethyl acetate. 6. A process of claim 1 wherein the acid used in step 6 is tartaric acid.
法律状态
(WO9106552) LEGAL DETAILS FOR WO9106552  Actual or expected expiration date=1993-04-30    Legal state=DEAD    Status=LAPSED     Event publication date=1990-10-26  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOUS9006187  Application date=1990-10-26  Standardized application number=1990WO-US06187     Event publication date=1991-05-16  Event code=WO/A1  Event type=Examination events  Published application with search report  Publication country=WO  Publication number=WO9106552  Publication stage Code=A1  Publication date=1991-05-16  Standardized publication number=WO9106552     Event publication date=1991-05-16  Event code=WO/AL  Event indicator=Pos  Event type=Designated states  Designated countries for regional patents AT BE CH DE DK ES FR GB GR IT LU NL SE    Event publication date=1991-05-16  Event code=WO/AK  Event indicator=Pos  Event type=Designated states  Designated states AU BR JP    Event publication date=1993-04-30  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. LEGAL DETAILS FOR DESIGNATED STATE BRPI9006982  Actual or expected expiration date=1997-05-06    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=BR Corresponding appl: BR9006982  Application date in the designated or member state=1990-10-26   Application number in the designated or member state=1990BR-0006982 Corresponding cc:  Designated or member state=BR Corresponding pat: BRPI9006982  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=1991-05-16   Publication number in the designated or member state=BRPI9006982    Event publication date=1997-05-06  Event code=BR/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=BR  LEGAL DETAILS FOR DESIGNATED STATE EP0454820  Actual or expected expiration date=1995-08-22    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=EP Corresponding appl: EP90916854  Application date in the designated or member state=1990-10-26   Application number in the designated or member state=1990EP-0916854 Corresponding cc:  Designated or member state=EP Corresponding pat: EP0454820  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=1991-11-06   Publication number in the designated or member state=EP-454820    Event publication date=1991-07-01  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=EP     Event publication date=1991-11-06  Event code=WO/WWP  Event indicator=Pos  Event type=Examination events  Wipo information: published in national office Corresponding cc:  Designated or member state=EP     Event publication date=1995-08-22  Event code=WO/WWW  Event indicator=Neg  Event type=Event indicating Not In Force  Wipo information: withdrawn in national office Corresponding cc:  Designated or member state=EP
专利类型码
A1
国别省市代码
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