Glycoengineering of Antibodies for Modulating Functions 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Annual Review of Biochemistry
年/卷/期
2019 / 88 /
页码
433-459
ISSN号
0066-4154
作者单位
Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA;Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA;Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA;Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA;Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA;
作者
Wang, Lai-Xi;Tong, Xin;Li, Chao;Giddens, John P.;Li, Tiezheng;
摘要
Antibodies are immunoglobulins that play essential roles in immune systems. All antibodies are glycoproteins that carry at least one or more conserved N-linked oligosaccharides (N-glycans) at the Fc domain. Many studies have demonstrated that both the presence and fine structures of the attached glycans can exert a profound impact on the biological functions and therapeutic efficacy of antibodies. However, antibodies usually exist as mixtures of heterogeneous glycoforms that are difficult to separate in pure glycoforms. Recent progress in glycoengineering has provided useful methods that enable production of glycan-defined and site-selectively modified antibodies for functional studies and for improved therapeutic efficacy. This review highlights major approaches in glycoengineering of antibodies with a focus on recent advances in three areas: glycoengineering through glycan biosynthetic pathway manipulation, glycoengineering through in vitro chemoenzymatic glycan remodeling, and glycoengineering of antibodies for site-specific antibody-drug conjugation.
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关键词/主题词
antibody;glycosylation;glycoengineering;chemoenzymatic;antibody-drug conjugate;
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