New forms and salts of a dihydropyrrolo[1,2-c]imidazolyl aldosterone synthase or aromatase inhibitor 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
EP2804863 B1 2015-12-02 [EP2804863]EP2804863 A1 2014-11-26 [EP2804863] / 2015-12-022014-11-26
申请号/申请日
2013EP-0701194 / 2013-01-15
发明人
SUTTON PAUL;LOESER ERIC;
申请人
NOVARTIS;
主分类号
IPC分类号
A61K-031/407A61P-005/38C07D-487/04
摘要
(EP2804863) The invention relates to a phosphate salt or a nitrate salt of 4-(R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl-3-fluoro-benzonitrile, especially in crystalline form, and specific forms of these salts, as well as related invention embodiments.  The salts and salt forms allow for the prophylactic and/or therapeutic treatment of aldosterone synthase and/or aromatase mediated diseases or disorders.  (From US9334276 B2)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2012US-61587280 2012-01-17 2013WO-US21521 2013-01-15
主权利要求
(EP2804863) 1. A phosphate salt of 4-(R)-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile in a crystalline form A with an XRPD showing at least one or all of the following peaks, given as angle of refraction 2-theta (theta ) values, where each peak may vary by +- 0.5 degrees: 12.9, 16.3 and 20.4 degrees; where the XRPD can be determined by using the following parameters and device: XRPD-methodInstrumentD8; Bruker (Karlsruhe, Germany)IrradiationCuKalpha (40 kV, 40 mA)Scan time4 minutes (2 minutes per frame)Scan range3 deg. - 40 deg. (2 theta value) (see table) [Unformatted table follows] -- XRPD-method -- Instrument D8; Bruker (Karlsruhe, Germany) -- Irradiation CuKalpha (40 kV, 40 mA) -- Scan time 4 minutes (2 minutes per frame) -- Scan range 3 deg. - 40 deg. (2 theta value) End table 11. A nitrate salt of 4-(R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl-3-fluoro-benzonitrile.
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(EP2804863) LEGAL DETAILS FOR EP2804863  Actual or expected expiration date=2033-01-15    Legal state=ALIVE    Status=GRANTED     Event publication date=2013-01-15  Event code=EP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=EP EP13701194  Application date=2013-01-15  Standardized application number=2013EP-0701194     Event publication date=2014-11-26  Event code=EP/A1  Event type=Examination events  Application published with search report  Publication country=EP  Publication number=EP2804863  Publication stage Code=A1  Publication date=2014-11-26  Standardized publication number=EP2804863     Event publication date=2014-11-26  Event code=EP/17P  Event indicator=Pos  Event type=Examination events  Request for examination filed Pruefungsantrag gestellt  Effective date of the event=2014-08-18     Event publication date=2014-11-26  Event code=EP/AK  Event indicator=Pos  Event type=Designated states  Designated contracting states: 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