Antibodies for epidermal growth factor receptor 3 (her3) 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
IN5544/DELNP/2014 A 2016-08-12 [IN2014DN05544] / 2016-08-12
申请号/申请日
2014IN-DN05544 / 2014-07-04
发明人
ELIS Winfried;ETTENBERG Seth;GARNER Andrew Paul;HAUBST Nicole;HUANG Xizhong;KUNZ Christian Carsten Silvester;REISINGER SPRAGUE Elizabeth Anne;SHENG Qing;
申请人
NOVARTIS;
主分类号
IPC分类号
A61K-031/395A61K-039/395C07K-016/32
摘要
(IN2014DN05544) This invention relates to antibodies or fragments thereof which interact with HER family of receptors e.g.  HER3 receptor.  In particular it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand dependent and ligand independent signal transduction; and allow ligand binding (e.g. neuregulin) whilst preventing ligand induced activation of signal transduction.  These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g. esophageal cancer).  These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g. prostate or uterine weights) or to induce atrophy of tissue (e.g. atrophy of male breast).  Alternatively these antibodies or fragments can be used to treat a disorder characterized by increased levels of HER3 expression in an esophageal tract gastric cancer or head and neck cancer.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2011US-61566890 2011-12-05
主权利要求

        
法律状态
(IN2014DN05544) LEGAL DETAILS FOR IN5544/DELNP/2014  Actual or expected expiration date=2032-12-04    Legal state=ALIVE    Status=PENDING     Event publication date=2014-07-04  Event code=IN/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=IN IN5544/DELNP/2014  Application date=2014-07-04  Standardized application number=2014IN-DN05544     Event publication date=2016-08-12  Event code=IN/A  Event indicator=Pos  Event type=Examination events  Application laid open  Publication country=IN  Publication number=IN5544/DELNP/2014  Publication stage Code=A  Publication date=2016-08-12  Standardized publication number=IN2014DN05544
专利类型码
A
国别省市代码
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