Molecular identification, genotyping, and drug susceptibility of the basidiomycetous yeast pathogen Trichosporon isolated from Turkish patients 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Medical mycology: official publication of the International Society for Human and Animal Mycology
年/卷/期
2010 / 48 / 1
页码
141-146
ISSN号
1369-3786
作者单位
Department of Microbiology and Clinical Microbiology, School of Medicine, Gazi University,Ankara;
作者
AYSE KALKANCI;TAKASHI SUGITA;SEVTAP ARIKAN;MINE YUCESOY;BEYZA ENER;FEZA OTAG;NURI KIRAZ;SEMRA KUSTIMUR;BANU SANCAK;CANAN EVCI;GUROL EMEKTAS;
摘要
Deep-seated infections due to Trichosporon species are emerging mycoses that have a very poor prognosis in patients with persistent neutropenia. This study elucidated the mycological characteristics of Trichosporon strains obtained from deep-seated infections in Turkish patients and identified by DNA sequence analysis of intergenic spacer (IGS) region 1 of the rDNA locus. In addition, we genotyped the major causative agent, T. asahii, and evaluated the in vitro drug susceptibility of the isolates. While 87 (81.3%) of the 107 isolates were T. asahii, the remaining 20 were T.faecale (14.0%), T. asteroids (0.9%), T. coremiiforme (0.9%), T.japonicum, (0.9%), T. lactis (0.9%), and anew species (0.9%). In addition to the eight known T. asahii genotypes, one novel genotype was identified. The distribution of the T. asahii genotypes in this study were genotype 1 (79.3%), followed by 5 (8.0%), 3 (6.9%), 6 (3.4%), 4 (1.1%), and 9 (1.1%). Turkish isolates showed low susceptibility to amphotericin B, 5-flucytosine, and fluconazole. Although relatively low minimum inhibitory concentrations (MICs) were found with all drugs, voriconazole appeared to be the most active. The MICs of the non-Trichosporon asahiiTrichosporon species were similar to those of the T. asahii strains. Our findings suggest that Trichosporon species isolated from Turkish patients are more diverse than those reported from other countries.
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关键词/主题词
Trichosporon asahii;genotype;drug susceptibility;Turkey;
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