Tertiary amine compounds 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
GB8530644 D0 1986-01-22 [GB8530644]GB2170197 A 1986-07-30 [GB2170197]GB2170197 B 1988-08-24 [GB2170197] / 1986-01-221986-07-301988-08-24
申请号/申请日
1985GB-0030644 / 1985-12-12
发明人
WORTHINGTON PAUL ANTHONY;SUGVANAM BALASUBRAMANYAN;
申请人
ICI - IMPERIAL CHEMICAL INDUSTRIES;
主分类号
IPC分类号
A01N-033/04A01N-033/10A01N-043/40A01N-043/60A01N-043/84A01N-055/00C07D-211/14C07D-211/22C07D-295/02C07D-295/03C07D-295/073C07D-295/096C07F-007/08
摘要

        
机翻摘要
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地址
代理人
代理机构
;
优先权号
1985GB-0001169 1985-01-17 1985GB-0012400 1985-05-16 1985GB-0016804 1985-07-03 1985GB-0020592 1985-08-16 1985GB-0029482 1985-11-29 1985GB-0030644 1985-12-12
主权利要求
(GB2170197) TABLEIII CONT/D Compound Puccinia Erysiphe Venturia Cercospora Number Recondita Graminis Inaequalis Arachidicola (Wheat) (Barley) (Apple)(Peanut) 129 2 4 4 3 130 2 4 1 4 131 1 4 4 4 132 3 4 4 0 133 4 4 4 3 1341 4 4 4 CLAIMS 1. Compounds having the general formula(I) and stereoisomers and acid addition salts thereof, wherein R',R2, R3, R4, R5 and R5 each represent a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or a halogen atom,R7 and R8 each represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms or together form a ring which may contain an addition hetero atom; and X and Y each represent a hydrogen or a halogen atom, or an alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, alkoxy or aryloxy group, or a group whereinR9, R10, R11 are alkyl, alkenyl, alkynyl, cycloalkyl, or aryl. 2. Compounds as claimed in claim 1 and of general formula(I) : and stereoisomers and acid addition salts thereof, whereinR', R2, R3, R4, R5 andR6, which may be the same or different, represent a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms, or a halogen atom;R and R8, which may be the same or different, represent a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms or together form a ring which may contain oxygen, nitrogen or sulphur as an additional heteroatom, and which ring may be optionally substituted; X and Y, which may bethe same or different, represent a hydrogen or a halogen atom, or an alkyl group containing from 1 to 6 carbon atoms, a cycloalkyl group containing from 3 to 6 carbon atoms, an alkenyl or alkynyl group each containing 2 to 6 carbon atoms, a phenyl group, a benzyl group, an alkoxy group containing from 1 to 6 carbon atoms, a phenoxy group, a benzyloxy group, or a group wherein R9, R10 and R11, which may be the same or different, represent an alkyl group containing up to 4 carbon atoms, an alkenyl or alkynyl group each containing from 2 to 4 carbon atoms, a cycloalkyl group containing from 3 to 6 carbon atoms, or a phenyl group. 3. Compounds as claimed in claim 1or claim 2 and of general formula (I) : and stereoisomers and acid addition salts thereof, whereinR1 and R2 are hydrogen, halogen orCaikyi ;R3 and R4 are hydrogen ;R5 and R6 are hydrogenor C, 4 al kyl ;R7 and R3 areC1 4 alkyl, or, together with the adjacent N-atom, represent a piperidine, morpholine, thiomorpholine or piperazine ring which may be substituted withCl-4 alkyl, phenyl, or hydroxymethyl ; and X and Y are hydrogen, halogen,Ci. alkyl, C1-4 alkoxy, phenyl, phenoxy, benzyl, benzyloxy or a group whereinR9, R10, and R11 are c1-4 alkyl. 4. Compounds as claimed in any of the preceding claims and of general formula (1) : and stereoisomers and acid addition salts thereof, whereinR'and R2 are hydrogen, methyl, or chlorine;R3 andR4 are hydrogen;R'and R'are hydrogen or methyl ;R andR are piperidine, 3,5-dimethyl piperidine, morpholine, 2,6-dimethylmorpholine, diethylamino, 4-phenyl piperidine, 3-hydroxymethyl piperidine, thiomorpholine, piperazine, or 4-phenylpiperazine ; and X and Y are substituents at the 3-or 4-positions of the phenyl ring and one of which is hydrogen orCn 4 alkyl whilst the other is hydrogen C1-4 alkyl, C1-4 alkoxy, chlorine, bromine, phenyl, phenoxy, benzyl, benzyloxy, or C1-4 trialkylsily. 5. The specific compounds set out in Table l ; and stereoisomers and acid addition salts thereof. 6. The compounds described in Examples 1 to 6 inclusive; and stereoisomers and acid addition salts thereof. 7. The compounds Compound No. 4 of TableI) (Compound No. 15. Of TableI) Compound No. < 94 of Table I) (Compound No. 133. Of TableI) 8. A process for preparing the compounds defined inc)aims1 to 7 which comprises the treatment of a compound of general formula(11) : wherein R',R2, R3, R4, R5, R6, X and Y are as defined and Z is a leaving group such as chlorine, bromine, mesylate or tosylate, with an amide of generalformula (111) : whereinR'and R8 are as defined above, in the presence of a convenient solvent such as ethanol or tetrahydrofuran, or, preferably, in the absence of a solvent at a temperature of 20 to100 C. 9. A process as claimed in claim 8 wherein the compounds(II) are prepared by treating an alcohol ofgeneral formula (IV) : wherein R',R2, R3, R4, R5, R6, X and Y are as defined with the usual haiogenating agents (eg. phosphorus trichloride, phosphoruspentachloride, or phosphorus oxychloride when Z = chlorine and phosphorus tribromide, phosphorus pentabromide, or phosphorus oxybromide when Z = bromine), ormesyl chloride inpyridine (or triethylamine) when Z = mesylate, or tosyl chloride in pyridine(or triethylamine) when Z = tosylate and wherein, if desired, either (a) thealcohols (IV) whereinR3 and R4 are both hydrogen are prepared by treating an ester of general formula (V) wherein R',R2, R5, R6, X, and Y are as defined above and R is alkyl with a reducing agent (usually lithium aluminium hydride) in a convenient solvent such asdiethyl ether or tetrahydrofuran or (b) the alcohols (IV), whereinR3 and R4 are both alkyl, are prepared by treating the above ester (V) with an excess of alkyl magnesium halide or an excess of alkyl lithium in a convenient solvent such asdiethyl ether or tetrahydrofuran, the esters (V) being prepared either by reacting the cinnamic esters of general formula(Vl) : wherein R,R5 and R6, X and Y are as defined above with a phosphorane of generalformula (Vil) : whereinR1 and R2 are defined above in a convenient solvent such as tetrahydrofuran or, in an alternative process the esters of general formula (V) wherein R5 is hydrogen are prepared by adding ethyl diazoacetate to the olefin of general formula(VIII) : wherein R',R2, R6, X and Y are as defined above, in a convenient solvent such as chloroform ordichloromethane using a suitable catalyst such as anhydrous copper sulphate. 10. A process for preparing the compounds of general formula(I) as claimed in claims 1 to 7 and whereR3 and R4 are both hydrogen, which comprises treating an amide of general formula (IX) : wherein R',R2, R5, R6, R7, R8, X and Y are as defined with a reducing agent (usually lithium aluminium hydride) in a convenient solvent such asdiethyl ether or tetrahydrofuran. 11. A process as claimed in claim 10 which comprises preparing amides of general formula (IX) by reacting an acid chloride of general formula (X): wherein R',R2, R5, R6, X and Y are as defined with an amide of general formula (III) : in a convenient solvent such asdiethyl ether or tetrahydrofuran, the acid chloride of general formula (X) being prepared by reacting an acid ofgeneral formula (Xl) : whereinR', R2, R5, R6, X and Y are as defined above with the usual chlorinating agents such as thionyl chloride or oxalyl chloride in a convenient solvent such as hexane ordichloromethane, the acid of generalformula XI being itself prepared by hydrolysing the ester (V) in the normal manner using either sodium or potassium hydroxide inmethanol/water solution at room temperature. 12. A fungicidal composition comprisinga compound of general formula 11) as claimed in any of claims 1 to 7 or acid addition salt or stereoisomer thereof ; and, optionally, a carrier or diluent. 13. A method of combating fungi, which comprises applying to a plant, to seed of a plant, or to the locus of a plant or seed, a compound, or an acid addition salt or stereoisomer thereof as claimed in any of claims 1 to 7 or a composition as claimed in claim 12. 14. As novel compounds, the intermediates of formulae11, IV, V,IX, X and Xi.
法律状态
(GB2170197) LEGAL DETAILS FOR GB8530644  Actual or expected expiration date=1992-12-12    Legal state=DEAD    Status=LAPSED     Event publication date=1985-12-12  Event code=GB/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=GB GB8530644  Application date=1985-12-12  Standardized application number=1985GB-0030644     Event publication date=1986-01-22  Event code=GB/D0  Event indicator=Pos  Event type=Examination events  Patent application filed  Publication country=GB  Publication number=GB8530644  Publication stage Code=D0  Publication date=1986-01-22  Standardized publication number=GB8530644     Event publication date=1986-07-30  Event code=GB/A  Event type=Examination events  Published Application  Publication country=GB  Publication number=GB2170197  Publication stage Code=A  Publication date=1986-07-30  Standardized publication number=GB2170197     Event publication date=1988-08-24  Event code=GB/B  Event indicator=Pos  Event type=Event indicating In Force  Patent specification  Publication country=GB  Publication number=GB2170197  Publication stage Code=B  Publication date=1988-08-24  Standardized publication number=GB2170197     Event publication date=1993-08-11  Event code=GB/PCNP  Event indicator=Neg  Event type=Event indicating Not In Force  Patent ceased through non-payment of renewal fee  Effective date of the event=1992-12-12     Event publication date=1993-08-18  Event code=GB/732E  Event type=Administrative notifications  Event type=Reassignment  Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
专利类型码
D0AB
国别省市代码
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