Ros-activated compounds as selective anti-cancer therapeutics 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
CA2866080 A1 2013-09-06 [CA2866080] / 2013-09-06
申请号/申请日
2013CA-2866080 / 2013-03-01
发明人
MERINO EDWARD J;MULLOY JAMES C;LI GUORUI;BELL-HORWATH TIFFANY;
申请人
CINCINNATI CHILDREN S HOSPITAL MEDICAL CENTER;UNIVERSITY OF CINCINNATI;
主分类号
IPC分类号
C07C-217/18C07C-217/20C07C-233/75C07C-237/04C07C-323/25C07D-295/096
摘要
(CA2866080) Provided are compounds according to the following Formula (I).  The Formula (I) compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS.  Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2012US-61605515 2012-03-01 2013WO-US28614 2013-03-01
主权利要求
(CA2866080) 1. A compound according to Formula I: wherein: R1 and R2 are each independently selected from the group consisting of H, straight or branched alkyl, aryl, and aralkyl, wherein said alkyl, aryl, and aralkyl can be substituted or unsubstituted with one or more substitutions and wherein said alkyl, aryl, and aralkyl can comprise one or more heteroatoms; R3 is selected from the group consisting of H, OH, NH2, NHC(O)CH3, piperidine, alkoxyl, OC(O)CH3, and CN; and n is 1-5. 20. A compound selected from the group consisting of: 4-(2-(phenylamino)ethoxy)phenol; 4-(2-(methyl(phenyl)amino)ethoxy)phenol; 4-(2-(ethyl(phenyl)amino)ethoxy)phenol; 4-(2-(isopropyl(phenyl)amino)ethoxy)phenol; 4-(2-((4-methoxyphenyl)amino)ethoxy)phenol; 4-(2-((4-methoxyphenyl)(methyl)amino)ethoxy)phenol; 4-(2-((4-bromophenyl)amino)ethoxy)phenol; 4-(2-(benzyl(methyl)amino)ethoxy)phenol; 4-(3-(methyl(phenyl)amino)propoxy)phenol; 4-(3-(ethyl(phenyl)amino)propoxy)phenol; 4-(4-(methyl(phenyl)amino)butoxy)phenol; 4-(4-(ethyl(phenyl)amino)butoxy)phenol; 4-(5-(methyl(phenyl)amino)pentyloxy)phenol; 4-((5-(methyl(phenyl)amino)pentyl)oxy)phenol; 4-((2-(ethyl(phenyl)amino)ethyl)thio)phenol; 4-((3-(methyl(phenyl)amino)propyl)thio)phenol; 2-(ethyl(phenyl)amino)-N-(4-hydroxyphenyl)acetamide; 3-(2-(ethyl(phenyl)amino)ethoxy)phenol; 2-(2-(ethyl(phenyl)amino)ethoxy)phenol; N-(4-(2-(ethyl(phenyl)amino)ethoxy)phenyl)acetamide; 4,4'-(2,2'-(phenylazanediyl)bis(ethane-2,1-diyl)bis(oxy))diphenol; 4. 4'-((((4-methoxyphenyl)azanediyl)bis(ethane-2,1-diyl))bis(oxy))diphenol; methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate; 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoic acid; and (((phenylazanediyl)bis(ethane-2,1-diyl))bis(oxy))bis(4,1-phenylene) diacetate.
法律状态
(CA2866080) LEGAL DETAILS FOR CA2866080  Actual or expected expiration date=2033-03-01    Legal state=ALIVE    Status=PENDING     Event publication date=2013-03-01  Event code=CA/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=CA CA2866080  Application date=2013-03-01  Standardized application number=2013CA-2866080     Event publication date=2013-09-06  Event code=CA/A1  Event type=Examination events  Application laid open  Publication country=CA  Publication number=CA2866080  Publication stage Code=A1  Publication date=2013-09-06  Standardized publication number=CA2866080
专利类型码
A1
国别省市代码
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