Preparation and compositions of zero-valent sulphur having high bioavailability, and uses thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
AU2015210403 A1 2015-09-03 [AU2015210403]AU2015210403 B2 2016-11-24 [AU2015210403] / 2015-09-032016-11-24
申请号/申请日
2015AU-0210403 / 2015-08-06
发明人
ROMANILLOS GABRIEL GOJON;ZORRILLA GABRIEL GOJON;
申请人
NUEVAS ALTERNATIVAS NATURALES;
主分类号
IPC分类号
A01N-059/02A61K-033/04A61K-033/06
摘要
(AU2015210403) PREPARATION AND COMPOSITIONS OF HIGHLY BIOAVAILABLE ZEROVALENT SULFUR AND USES THEREOF Abstract 5 The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability.  The invention also includes methods of treating pathological conditions associated with oxidative stress using sulfur-rich compositions.  The invention further includes sulfur-rich compositions as antidotes and medical food for preserving and promoting general health.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2011US-61534585 2011-09-14 2012AU-0321444 2012-09-13 2015AU-0210403 2015-08-06
主权利要求
(AU2015210403) 1. CLAIMS A composition comprising 90-99.9% (w/w) elemental alpha sulfur and 0.01-10% (w/w) highly polar components, and optionally comprising one or more pharmaceutically acceptable excipients. 2. The composition of claim 1, said composition comprising about 99% (w/w) zerovalent sulfur and about 1% (w/w) highly polar components, wherein said highly polar components are selected from sodium sulfate, sodium polythionates, and sodium thiosulfate. 3. The composition of claim 1, wherein said highly polar components are selected from the group consisting of sodium polythionate, potassium polythionate, ammonium polythionate, calcium polythionate, sodium thiosulfate, potassium thiosulfate, ammonium thiosulfate, calcium thiosulfate, sodium sulfate, potassium sulfate, ammonium sulfate, sodium bisulfite, potassium bisulfite, ammonium bisulfite, calcium bisulfite, sodium chloride, potassium chloride, ammonium chloride, calcium chloride, sodium acetate, sodium palmitate, potassium palmitate, and ammonium laurate. 4. A composition comprising an elemental alpha sulfur and one or more highly polar components in a ratio from about 10 to about 150 parts elemental alpha sulfur to 1 part highly polar components (w/w) for enteral, topical, or parenteral administration. 5. The composition of claim 4, wherein said composition is formulated for enteral administration and said elemental alpha sulfur and said highly polar components are present together in an amount of 400 mg. 6. The composition of claim 5, wherein said composition is a capsule. 7. The composition of claim 2, wherein said composition is formulated for topical administration, and said composition comprises 1-20% zerovalent sulfur content. 8. The composition of claim 7, wherein said composition is a cream. 9. The composition of claim 8, wherein said cream comprises (i) 5-20% zerovalent sulfur content and (ii) polyethylene glycol or petroleum jelly. 10. The composition of claim 9, wherein said cream comprises 5-15% zerovalent sulfur content. 57 11. The composition of claim 4, further comprising a third agent. 12. The composition of claim 11, wherein said third agent is a cardiovascular disease drug, an antiinflammatory drug, an anti-neurodegenerative drug, or an anticancer/anti-proliferative drug. 13. The composition of claim 11, wherein said elemental alpha sulfur, said highly polar components, and said third agent are present in an effective amount to treat a condition associated with oxidative stress. 14. The composition of claim 11, wherein said third agent is a dietary supplement. 15. The composition of claim 11, wherein said elemental alpha sulfur, said highly polar components, and said third agent are present in an effective amount to promote or maintain general health. 16. A method for preparing the composition of claim 1, said method comprising: (a) providing a first inorganic compound comprising sulfur in the -2 (minus two) oxidation state, (b) reacting said first inorganic compound with a second compound comprising sulfur in the +4 (plus four) oxidation state and optionally an acid, wherein said reacting produces the composition of claim 1. 17. The method of claim 16, wherein said first inorganic compound is sodium hydrogen sulfide or sodium sulfide. 18. The method of claim 16, wherein said second inorganic compound is sodium metabisulfite, sodium bisulfate, or sodium sulfite. 19. The method of claim 16, wherein said acid is concentrated sulfuric acid.
法律状态
(AU2015210403) LEGAL DETAILS FOR AU2015210403  Actual or expected expiration date=2032-09-13    Legal state=ALIVE    Status=GRANTED     Event publication date=2015-08-06  Event code=AU/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=AU AU2015210403  Application date=2015-08-06  Standardized application number=2015AU-0210403     Event publication date=2015-09-03  Event code=AU/A1  Event indicator=Pos  Event type=Examination events  Open to public inspection  Publication country=AU  Publication number=AU2015210403  Publication stage Code=A1  Publication date=2015-09-03  Standardized publication number=AU2015210403     Event publication date=2016-10-27  Event code=AU/HB  Event type=Change of name or address  Event type=Reassignment  Alteration of name in register Owner: NUEVAS ALTERNATIVAS NATURALES, S.A. DE C.V. FORMER NAME(S): NUEVAS ALTERNATIVAS NATURALES, S.A.P.I. DE C.V.     Event publication date=2016-11-24  Event code=AU/B2  Event indicator=Pos  Event type=Event indicating In Force  Patent proceeded by OPI  Publication country=AU  Publication number=AU2015210403  Publication stage Code=B2  Publication date=2016-11-24  Standardized publication number=AU2015210403     Event publication date=2017-03-23  Event code=AU/FGA  Event indicator=Pos  Event type=Event indicating In Force  Letters patent sealed or granted (standard patent)
专利类型码
A1B2
国别省市代码
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