Method and composition for potentiating an oplate analgesic 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2004220203 A1 2004-11-04 [US20040220203]US7256200 B2 2007-08-14 [US7256200] / 2004-11-042007-08-14
申请号/申请日
2004US-10769536 / 2004-01-30
发明人
WANG ZAIJIE;
申请人
UNIVERSITY OF ILLINOIS;
主分类号
IPC分类号
A01N-043/42A61KA61K-031/18A61K-031/485A61K-031/7052A61K-038/04A61K-045/06A61P-025/04
摘要
(US7256200) Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed.  The composition and method utilize an opiate analgesic and a calcium calmodulin kinase (CaMKII) inhibitor as active agents to treat pain in mammals, including humans.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2003US-60446232 2003-02-10 2004US-10769536 2004-01-30
主权利要求
(US7256200) What is claimed is: 1.  A method for reducing tolerance to an opiate analgesic in an individual undergoing opiate analgesic therapy comprising administering intrathecally to an individual an effective amount of KN93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine) which inhibits the activity of spinal calmodulin dependent protein kinase II.
法律状态
(US7256200) LEGAL DETAILS FOR US2004220203  Actual or expected expiration date=2015-09-14    Legal state=DEAD    Status=LAPSED     Event publication date=2004-01-30  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US10769536  Application date=2004-01-30  Standardized application number=2004US-10769536     Event publication date=2004-01-30  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: KHANNA, HEMANT    Event publication date=2004-01-30  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1654     Event publication date=2004-01-30  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status Business Entity Status: SMALL    Event publication date=2004-01-30  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2004-01-30  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: UIC0002US    Event publication date=2004-01-30  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 26259    Event publication date=2004-06-16  Event code=US/INCD  Event type=Examination events  Event type=OAO  Notice Mailed--Application Incomplete--Filing Date Assigned    Event publication date=2004-09-08  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2004-10-12  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2004-11-04  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2004220203  Publication stage Code=A1  Publication date=2004-11-04  Standardized publication number=US20040220203     Event publication date=2004-12-06  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2006-02-21  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2006-03-30  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2006-04-20  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2006-04-28  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2006-05-04  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2006-05-30  Event code=US/AINEA  Event type=OAI  Event type=Examination events  Informal or Non-Responsive Amendment after Examiner Action    Event publication date=2006-05-30  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2006-08-07  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2006-09-05  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2006-10-30  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2007-01-29  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2007-03-28  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2007-04-10  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2007-04-10  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2007-07-05  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2007-07-25  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=2007-08-14  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US7256200  Publication stage Code=B2  Publication date=2007-08-14  Standardized publication number=US7256200     Event publication date=2007-08-14  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 366  Overlap Delays: 0  Non Overlap Delays: 366   PTO Office Delays: 0  Applicant Delays: 98  Adjustment total:  Number of days of extension=268    Event publication date=2011-03-14  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2011-03-14     Year of payment of annual fees=4     Event publication date=2011-03-14  Event code=US/SULP  Event indicator=Pos  Event type=Restitution or restoration  Event type=Event indicating In Force  Surcharge for late payment    Event publication date=2015-03-27  Event code=US/REMI  Event type=Administrative notifications  Maintenance fee reminder mailed    Event publication date=2015-08-14  Event code=US/LAPS  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapse for failure to pay maintenance fees    Event publication date=2015-08-14  Event code=US/FP  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Expired due to failure to pay maintenance fee  Effective date of the event=2015-08-14     Event publication date=2015-09-11  Event code=US/EXP  Event indicator=Neg  Event type=Event indicating Not In Force  Patent expired    Event publication date=2015-09-14  Event code=US/FP  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Expired due to failure to pay maintenance fee
专利类型码
A1B2
国别省市代码
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