Yield limiting diseases such as charcoal rot and Phomopsis seed decay have a significant impact on the economic potential for soybeans because there are few methods for management of these diseases. The objectives of this study were to evaluate application of the herbicide lactofen, the fungicide azoxystrobin, and soybean genotype effects on charcoal rot and Phomopsis seed decay. Bacterial blight and pod and stem blight also developed during the course of this study, and the effects of treatments on these diseases were evaluated. Application of lactofen and azoxystrobin had no significant impact on severity of charcoal rot, percent of harvested seed infected by Phomopsis spp., or severity of pod and stem blight and bacterial blight. No genotype evaluated was resistant to Phomopsis seed decay. This is the first report of high levels of resistance in PI 567562A to charcoal rot and resistance was greater than for DT 97-4290.