Use of liposome encapsulated cirprofloxacin as an immunotherapeutic drug 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US5968548 A 1999-10-19 [US5968548] / 1999-10-19
申请号/申请日
1997US-08843589 / 1997-04-16
发明人
WONG JONATHAN P;SARAVOLAC EDWARD G;NAGATA LES P;
申请人
UK SECRETARY OF DEFENCE;
主分类号
IPC分类号
A01N-043/42A61K-009/127A61K-031/47A61K-031/495
摘要
(US5968548) Liposome-encapsulated quinolones and specifically liposome-encapsulated ciprofloxacin dramatically enhances macrophage functions, induces NO production and augments the production of cytokines, rendering the composition an immunoprophylactic and immunotherapeutic agent with unique clinical potential.  Liposome-encapsulated ciprofloxacin and other quinolones could be extremely useful in antimicrobial, anticancer and AIDS therapies.  In such cases, the immunological status of the patient is often compromised or suppressed, making them susceptible to microbial infections and to the development of tumor growth.  Selective augmentation of cellular immunity by activation of the microbicidal and tumoricidal activities of macrophages, induction of NO and cytokine production could be of primary importance to such patients in terms of protecting them against microbial infections and inducing their cellular host defense to tumor cells.
机翻摘要
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地址
代理人
代理机构
;
优先权号
1996CA-2174803 1996-04-23
主权利要求
(US5968548) The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1.  A method of enhancing nitrogen oxide in macrophages of an animal to thereby enhance the phagocytic activity of said macrophages said method comprising administering to said animal an effective amount of ciprofloxacin encapsulated in liposomes. 2. A method of increasing the cellular levels of interferon gamma, tumor necrosis factor-alpha or both to thereby increase the phagocytic activity of macrophages in an animal, said method comprising administering to said animal an effective amount of ciprofloxacin encapsulated in liposomes.
法律状态
(US5968548) LEGAL DETAILS FOR US5968548  Actual or expected expiration date=2017-04-16    Legal state=DEAD    Status=EXPIRED     Event publication date=1997-04-16  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US08843589  Application date=1997-04-16  Standardized application number=1997US-08843589     Event publication date=1997-04-16  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: LEE, DATQUAN HUU    Event publication date=1997-04-16  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1643     Event publication date=1997-04-16  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 93-95    Event publication date=1997-04-16  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=1997-04-16  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=1997-09-30  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=1997-10-01  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=1997-10-01  Event code=US/APE  Event type=Corrections  Preliminary amendments    Event publication date=1997-10-27  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=1998-01-30  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=1998-01-30  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=1998-04-27  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=1998-09-10  Event code=US/CTFAR  Event type=Examination events  Event type=OAI  Response after Final Action    Event publication date=1998-09-10  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=1998-09-22  Event code=US/DCTC  Event type=OAO  Terminal Disclaimer Approved in TC    Event publication date=1998-10-07  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=1998-10-28  Event code=US/SUPRSP  Event type=OAI  Supplemental Response    Event publication date=1998-11-04  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=1999-01-20  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=1998-03-02  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:WONG, JONATHAN P. NAGATA, LES P. REEL/FRAME:009710/0561     Event publication date=1999-01-20  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=1997-02-11  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:SARAVOLAC, EDWARD G. REEL/FRAME:009710/0577     Event publication date=1999-10-03  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=1999-10-12  Event code=US/PAT  Event indicator=Pos  Event type=Event indicating In Force  Patented Case    Event publication date=1999-10-12  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=1999-10-19  Event code=US/A  Event indicator=Pos  Event type=Event indicating In Force  Patents Granted before 2001-04-15  Publication country=US  Publication number=US5968548  Publication stage Code=A  Publication date=1999-10-19  Standardized publication number=US5968548     Event publication date=2002-10-29  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=3     Event publication date=2003-04-01  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2003-04-01     Year of payment of annual fees=4     Event publication date=2006-10-31  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=7     Event publication date=2007-03-20  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2007-03-20     Year of payment of annual fees=8     Event publication date=2010-11-02  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=11     Event publication date=2011-03-23  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2011-03-23     Year of payment of annual fees=12     Event publication date=2017-04-16  Event code=US/EEDX  Event indicator=Neg  Event type=Event indicating Not In Force  Patent has expired
专利类型码
A
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