Anti-malarial agents 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
EP2814820 B1 2016-07-20 [EP2814820]EP2814820 A1 2014-12-24 [EP2814820] / 2016-07-202014-12-24
申请号/申请日
2013EP-0712926 / 2013-02-15
发明人
YOUNIS YASSIR;CHIBALE KELLY;WITTY MICHAEL JOHN;WATERSON DAVID;
申请人
MEDICINES FOR MALARIA VENTURE (MMV);UNIVERSITY OF CAPE TOWN;
主分类号
IPC分类号
A61K-031/444A61K-031/497A61P-033/06C07D-241/26C07D-401/04C07D-401/10C07D-401/14C07D-413/10
摘要
(EP2814820) The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria.  Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.  In one embodiment, the invention provides aminopyrazine derivatives having the following formula:  (From US9266842 B2)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2012US-61600324 2012-02-17 2013WO-IB51235 2013-02-15
主权利要求
(EP2814820) 1. An aminopyrazine according to Formula (I), (see diagram) wherein X is CR **1 or N; Y is selected from CF 3, -C(O)-NR **3R **4; O-R **6; SO 2-R **6; R **1 is selected from H and halogen; R **2 is selected from SO 2-R **5 and -C(O)-R **10; R **3 and R **4 are independently selected from H and optionally substituted C 1-C 6 alkyl; R **5 is selected from -NR **7R **8 and R **9; R **6 is optionally substituted C 1-C 6 alkyl; R **7 and R **8 are independently selected from H and optionally substituted C 1-C 6 alkyl; R **9 is optionally substituted C 1-C 6 alkyl or optionally substituted C 3-C 8 cycloalkyl; R **10 is -NR **11R **12; R **11 and R **12 are independently selected from H and optionally substituted C 1-C 6 alkyl or NR **11R **12 form together an optionally substituted heterocycloalkyl; as well as pharmaceutically acceptable salts, complexes, hydrates, solvates, or polymorphs, tautomers, geometrical isomers, optically active forms thereof, wherein optionally substituted refers to groups substituted with from 1 to 5 substituents selected from the group consisting of "C 1-C 6 alkyl," " "C 3-C 8-cycloalkyl," "amino," "halogen," hydroxy, and nitro.
法律状态
(EP2814820) LEGAL DETAILS FOR EP2814820  Actual or expected expiration date=2033-02-15    Legal state=ALIVE    Status=GRANTED     Event publication date=2013-02-15  Event code=EP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=EP EP13712926  Application date=2013-02-15  Standardized application number=2013EP-0712926     Event publication date=2014-12-24  Event code=EP/A1  Event type=Examination events  Application published with search report  Publication country=EP  Publication number=EP2814820  Publication stage Code=A1  Publication date=2014-12-24  Standardized publication number=EP2814820     Event publication date=2014-12-24  Event code=EP/17P  Event indicator=Pos  Event type=Examination events  Request for examination filed Pruefungsantrag gestellt  Effective date of the event=2014-09-09     Event publication date=2014-12-24  Event code=EP/AK  Event indicator=Pos  Event type=Designated states  Designated contracting states: 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专利类型码
B1A1
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