Fungicidal compounds and mixtures 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2009055514 A2 2009-04-30 [WO200955514]WO2009055514 A3 2010-03-25 [WO200955514] / 2009-04-302010-03-25
申请号/申请日
2008WO-US80850 / 2008-10-23
发明人
GREGORY VANN;PASTERIS ROBERT JAMES;
申请人
DU PONT DE NEMOURS;
主分类号
IPC分类号
A01N-043/40A01N-043/56A01N-043/653A01N-043/78A01N-043/80A01N-043/90A01P-003/00C07D-261/00C07D-277/00
摘要
(WO200955514) Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1 N-oxides, and salts thereof, wherein R1, R2, A, G, W, Z1, X, J, and n are as defined in the disclosure, and (b) at least one additional fungicidal compound.  Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of the aforesaid composition.  Also disclosed is a composition comprising component (a) of aforesaid composition and at least one insecticide.  Also disclosed are compounds of Formula 1A, 1B and 1C, wherein R1, R2, A, G, W, Z1, X, J, n, Z3, M and J1are as defined in the disclosure.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2007US-61000002 2007-10-23 2008US-61062400 2008-01-25
主权利要求
(WO200955514) 1. CLAIMS What is claimed is: 1. A fungicidal composition comprising: (a) at least one compound selected from the compounds of Formula 1, JV-oxides, and salts thereof,  wherein R1is an optionally substituted phenyl, naphthalenyl or 5- or 6-membered heteroaromatic ring; A is CHR15or NR16; R15is H, halogen, cyano, hydroxy, -CHO, Q-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, Q-C4haloalkyl, C2-C4haloalkenyl, C2-C4haloalkynyl, C2-C4alkoxyalkyl, C2-C4alkylthioalkyl, C2-C4alkylsulfmylalkyl, C2-C4alkylsulfonylalkyl, C3-C5alkoxycarbonylalkyl, C2-C4alkylcarbonyl, C2-C4haloalkylcarbonyl, C2-C5alkoxycarbonyl, C2-C5alkylaminocarbonyl, C3-C5dialkylaminocarbonyl, Q-C4alkoxy, Q-C4haloalkoxy, Q-C4alkylthio, Q-C4haloalkylthio, Q-C4alkylsulfϊnyl, Q-C4haloalkylsulfϊnyl, Q-C4alkylsulfonyl or Q-C4haloalkylsulfonyl; or R15is -SH, amino, Q-C6hydroxyalkyl, C2-C4alkenyloxy, C2-C4alkynyloxy, C2-C4haloalkenyloxy, C2-C4haloalkynyloxy, C2-C5alkylcarbonyloxy, C2-C5alkoxycarbonyloxy, C2-C5haloalkylcarbonyloxy, C2-C5haloalkoxycarbonyloxy, C2-C5alkylaminocarbonyloxy, C3-C6dialkylaminocarbonyloxy, C2-C5haloalkylaminocarbonyloxy, C3-C6halodialkylaminocarbonyloxy, C2-C5alkoxyalkoxy, C2-C5haloalkoxyalkoxy, C^-C4alkylsulfonyloxy, Q-C4haloalkylsulfonyloxy, C3-Qo trialkylsilyloxy, C2-C4alkenylthio, C2-C4alkynylthio, C2-C4haloalkenylthio, C2-C4haloalkynylthio, C2-C5alkylcarbonylthio, C2-C5alkoxy carbonylthio, C2-C5haloalkylcarbonylthio, C2-C5haloalkoxycarbonylthio, C2-C5alkylaminocarbonylthio, C3-C6dialkylaminocarbonylthio, C2-C5haloalkylaminocarbonylthio, C3-C6halodialkylaminocarbonylthio, C2-C5alkoxy alkylthio, C2-C5haloalkoxyalkylthio, Q-C4alkylsulfonylthio, Q-C4haloalkylsulfonylthio, C3-C10trialkylsilylthio, C1-C4alkylamino, C2-C4alkenylamino, C2-C4alkynylamino, C2-C4dialkylamino, C1-C4haloalkylamino, C2-C4haloalkenylamino, C2-C4haloalkynylamino, C2-C4halodialkylamino, C2-C5alkylcarbonylamino, C2-C5haloalkylcarbonylamino, C2-C5alkoxycarbonylamino, C2-C5haloalkoxycarbonylamino, C2-C5alkylaminocarbonylamino, C3-C6dialkylamino carbonylamino, C2-C5haloalkylaminocarbonylamino, C3-C6halodialkylaminocarbonylamino, C2-C5alkoxy alkylamino, C2-C5haloalkoxyalkylamino, C1-C4alkylsulfonylamino or C1-C4haloalkylsulfonylamino; R16is H, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4haloalkyl, C2-C4haloalkenyl, C2-C4haloalkynyl, C2-C4alkoxyalkyl, C2-C4alkylthioalkyl, C2-C4alkylsulfinylalkyl, C2-C4alkylsulfonylalkyl, C2-C4alkylcarbonyl, C2-C4haloalkylcarbonyl, C2-C5alkoxycarbonyl, C3-C5alkoxycarbonylalkyl, C2-C5alkylaminocarbonyl, C3-C5dialkylaminocarbonyl, C1-C4alkylsulfonyl or C1-C4haloalkylsulfonyl; W is O or S; X is a radical selected from  X1X^ xjX4 X5X6X'  X8X9wherein the bond of X1, X2, X3, X4, X5, X6, X7, X8or X9which is identified with "t" is connected to the carbon atom identified with "q" of Formula 1, the bond which is identified with "u" is connected to the carbon atom identified with "r" of Formula 1, and the bond which is identified with "v" is connected to G; each R2is independently halogen, cyano, hydroxy, C1-C4alkyl, C1-C4alkenyl, C1-C4haloalkyl or C1-C4alkoxy; or two R2are taken together as C1-C4alkylene or C2-C4alkenylene to form a bridged bicyclic or fused bicyclic ring system; or two R2attached to adjacent ring carbon atoms joined by a double bond are taken together as -CH=CH-CH=CH- optionally substituted with 1 to 3 substituents selected from halogen, hydroxy, amino, cyano, nitro, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy and C1-C4haloalkoxy; G is an optionally substituted 5-membered heteroaromatic ring or 5-membered saturated or partially saturated heterocyclic ring; J is a 5-, 6- or 7-membered ring, an 8- to 11-membered bicyclic ring system or a 7- to 11-membered spirocyclic ring system, each ring or ring system containing ring members selected from carbon and optionally 1 to 4 heteroatoms selected from up to 2 O, up to 2 S and up to 4 N, and optionally including 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O), S(O)2and SiR17R18, each ring or ring system optionally substituted with 1 to 5 substituents independently selected from R5; each R5is independently H, halogen, cyano, hydroxy, amino, nitro, -CHO, -C(=0)0H, -C(K))NH2, -NR25R26, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C8cycloalkyl, C3-C8halocycloalkyl, C4-C10alkylcycloalkyl, C4-C10cycloalkylalkyl, C6-C14cycloalkylcycloalkyl, C4-C10halocycloalkylalkyl, C5-C10alkylcycloalkylalkyl, C3-C8cycloalkenyl, C3-C8halocycloalkenyl, C2-C6alkoxyalkyl, C2-C6haloalkoxyalkyl, C1-C6hydroxyalkyl, C4-C10cycloalkoxyalkyl, C3-C8alkoxyalkoxyalkyl, C2-C6alkylthioalkyl, C2-C6alkylsulfmylalkyl, C2-C6alkylsulfonylalkyl, C2-C6alkylaminoalkyl, C2-C6haloalkylaminoalkyl, C3-C8dialkylaminoalkyl, C4-C10cycloalkylaminoalkyl, C2-C6alkylcarbonyl, C2-C6haloalkylcarbonyl, C4-C8cycloalkylcarbonyl, C2-C6alkoxycarbonyl, C4-C8cycloalkoxycarbonyl, C5-C10cycloalkylalkoxycarbonyl, C2-C6alkylaminocarbonyl, C3-C8dialkylaminocarbonyl, C4-C8cycloalkylaminocarbonyl, C1-C6alkoxy, C1-C6haloalkoxy, C3-C8cycloalkoxy, C3-C8halocycloalkoxy, C4-C10cycloalkylalkoxy, C2-C6alkenyloxy, C2-C6haloalkenyloxy, C2-C6alkynyloxy, C2-C6haloalkynyloxy, C2-C6alkoxyalkoxy, C2 -C6alkylcarbonyloxy, C2-C6haloalkylcarbonyloxy, C4-C8cycloalkylcarbonyloxy, C3-C6alkylcarbonylalkoxy, C1-C6alkylthio, C1-C6haloalkylthio, C3-C8cycloalkylthio, C1-C6alkylsulfmyl, C1-C6haloalkylsulfinyl, C1-C6alkylsulfonyl, C1-C6haloalkylsulfonyl, C3-C8cycloalkylsulfonyl, C3-C10trialkylsilyl, C1-C6alkylsulfonylamino, C1-C6haloalkylsulfonylamino or -Z2Q; each R25is independently H, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, C2-C6alkylcarbonyl, C2-C6haloalkylcarbonyl, C2-C6alkoxycarbonyl or C2-C6haloalkoxycarbonyl; each R26is independently C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, C2-C6alkylcarbonyl, C2-C6haloalkylcarbonyl, C2-C6alkoxycarbonyl, C2-C6haloalkoxycarbonyl or -Z4Q; each R17and R18is independently C1-C5alkyl, C2-C5alkenyl, C2-C5alkynyl, C3-C5cycloalkyl, C3-C6halocycloalkyl, C4-C10cycloalkylalkyl, C4-C7 alkylcycloalkyl, C5-C7alkylcycloalkylalkyl, C1-C5haloalkyl, C1-C5alkoxy or C1-C5haloalkoxy; each Q is independently a phenyl, a benzyl, a naphthalenyl, a 5- or 6-membered heteroaromatic ring or an 8- to 11-membered heteroaromatic bicyclic ring system, each ring or ring system optionally substituted with 1 to 5 substituents independently selected from R7on carbon atom ring members and R12on nitrogen atom ring members; or each Q is independently a 3- to 7-membered nonaromatic carbocyclic ring, a 5-, 6- or 7-membered nonaromatic heterocyclic ring or an 8- to 11-membered nonaromatic bicyclic ring system, each ring or ring system optionally including ring members selected from the group consisting of C(=O), C(=S), S(O), S(O)2and SiR17R18, and optionally substituted with 1 to 5 substituents independently selected from R7on carbon atom ring members and R12on nitrogen atom ring members; each R7is independently halogen, hydroxy, amino, cyano, nitro, C1 -C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C4-C10cycloalkylalkyl, C4-C10alkylcycloalkyl, C5-C10alkylcycloalkylalkyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6halocycloalkyl, C2-C4alkoxyalkyl, C1-C4hydroxyalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C2-C6alkylcarbonyloxy, C1-C4alkylthio, C1-C4haloalkylthio, C2-C6alkylcarbonylthio, C1-C4alkylsulfmyl, C1-C4alkylsulfonyl, C1-C4haloalkylsulfϊnyl, C1-C4haloalkylsulfonyl, C1-C4alkylamino, C2-C8dialkylamino, C3-C6cycloalkylamino, C2-C4alkylcarbonyl, C2-C6alkoxycarbonyl, C2-C6alkylaminocarbonyl, C3-C8dialkylaminocarbonyl or C3-C6trialkylsilyl; or R5and R7are taken together with the atoms linking R5and R7to form an optionally substituted 5- to 7-membered ring containing ring members selected from carbon and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 1 N and optionally including 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O), S(O)2and SiR17R18; each R12is independently H, C1-C3alkyl, C1-C3alkylcarbonyl, C1-C3alkoxycarbonyl or C1-C3alkoxy; each Z1and Z2is independently a direct bond, O, C(=O), S(O)m, CHR20or NR21; each Z4is independently O, C(=O), S(O)mor CHR20; each R20is independently H, C1-C4alkyl or C1-C4haloalkyl; each R21is independently H, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, C2-C6alkylcarbonyl, C2-C6haloalkylcarbonyl, C2-C6alkoxycarbonyl or C2-C6haloalkoxycarbonyl; each m is independently 0, 1 or 2; and n is 0, 1 or 2; and (b) at least one additional fungicidal compound. 2. The composition of Claim 1 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein G is a 5-membered heteroaromatic ring or a 5-membered saturated or partially saturated heterocyclic ring, each ring optionally substituted with up to 2 substituents selected from R3on carbon ring members and selected from R11on nitrogen ring members; R1is a phenyl or a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 2 substituents independently selected from R4aon carbon ring members and R4^ on nitrogen ring members; each R2is independently halogen, cyano, hydroxy, C1-C2alkyl, C1-C2haloalkyl or C1-C2alkoxy; each R3is independently halogen, C1-C3alkyl or C1-C3haloalkyl; each R4ais independently halogen, hydroxy, amino, cyano, nitro, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6cycloalkyl, C4-C10cycloalkylalkyl, C4-C10alkylcycloalkyl, C5-C10alkylcycloalkylalkyl, C3-C6halocycloalkyl, C2-C4alkoxyalkyl, C1-C4hydroxyalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C2-C6alkylcarbonyloxy, C1-C4alkylthio, C1-C4haloalkylthio, C2-C6alkylcarbonylthio, C1-C4alkylsulfmyl, C1-C4alkylsulfonyl, C1-C4haloalkylsulfϊnyl, C1-C4haloalkylsulfonyl, C1-C4alkylamino, C2-Cg dialkylamino, C3-C6cycloalkylamino, C2-C4alkylcarbonyl, C2-C6alkoxycarbonyl, C2-C6alkylaminocarbonyl, C3-Cg dialkylaminocarbonyl or C3-C6trialkylsilyl; each R4b is independently C1-C6alkyl, C3-C6alkenyl, C3-C6alkynyl, C3-C6cycloalkyl, C1-C6haloalkyl, C3-C6haloalkenyl, C3-C6haloalkynyl, C3-C6halocycloalkyl or C2-C4alkoxyalkyl; each R11is independently C1-C3alkyl; R15is H, halogen, cyano, hydroxy, -CHO, C1-C4alkyl, C1-C4haloalkyl or C2-C5alkoxycarbonyl; or R15is C2-C4alkenyloxy, C2-C4alkynyloxy, C2-C4haloalkenyloxy, C2-C4haloalkynyloxy, C2-C5alkylcarbonyloxy, C2-C5alkoxycarbonyloxy, C2-C5haloalkylcarbonyloxy, C2-C5haloalkoxycarbonyloxy, C2-C5alkylaminocarbonyloxy, C3-C6dialkylaminocarbonyloxy, C2-C5haloalkylaminocarbonyloxy, C3-C6halodialkylaminocarbonyloxy, C2-C5alkoxyalkoxy, C2-C5haloalkoxyalkoxy, C1-C4alkylsulfonyloxy, C1-C4haloalkylsulfonyloxy or C3-C1Qtrialkylsilyloxy; R16is H, C1-C4alkyl, C1-C4haloalkyl, C2-C4alkylcarbonyl, C2-C4haloalkylcarbonyl or C2-C4alkoxycarbonyl; when R5and R7are taken together with the atoms linking R5and R7to form an optionally substituted 5- to 7-membered ring, then R5and R7are taken together with the atoms linking R5and R7to form a 5- to 7-membered ring containing ring members selected from carbon and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 1 N, and optionally including 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O), S(O)2and SiR17R18, the ring optionally substituted on ring members other than the atoms linking R5and R7with up to 4 substituents selected from R8; each R8is independently halogen, hydroxy, amino, cyano, nitro, C1-C6alkyl, C2-C6alkenyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C2-C6alkynyl, C3"C6cycloalkyl, C4-C1Qcycloalkylalkyl, C4-C1Qalkylcycloalkyl, C5-C1Qalkylcycloalkylalkyl, C3-C6halocycloalkyl, C2-C4alkoxyalkyl, C1-C4hydroxyalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C2-C6alkylcarbonyloxy, C1-C4alkylthio, C1-C4haloalkylthio, C2-C6alkylcarbonylthio, C1-C4alkylsulfmyl, C1-C4alkylsulfonyl, C1-C4haloalkylsulfϊnyl, C1-C4haloalkylsulfonyl, C1-C4alkylamino, C2-C8dialkylamino, C3-C6cycloalkylamino, C2-C4alkylcarbonyl, C2-C6alkoxycarbonyl, C2-C6alkylaminocarbonyl, C3-Cg dialkylaminocarbonyl or C3-C6trialkylsilyl; and each Z4is independently C(=O) or S(O)2. 3. The composition of Claim 2 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein G is one of G-I through G-59 wherein the bond projecting to the left is bonded to X, and bond projecting to the right is bonded to Z1 G-I G-2 G-3 G-4  G-13 G-14 G-15 G-16  G-17 G-18 G-19 G-20  G-29 G-30 G-31 G-32 G-33 G-34 G-35 G-36  G-45 G-46 G-47 G-48  G-57 G-59 J is one of J-I through J-82 wherein the bond shown projecting to the left is bonded to zi  J-I J-2 J-3 J-4  J-5 J-6 J-7 J-8  J-9 J-IO J-I l J-12  J-13 J-14 J-15 J-16  J-17 J-18 J-19 J-20  J-21 J-22 J-23 J-24  J-25 J-26 J-27 J-28  J-29 J-30 J-31 J-32  J-33 J-34 J-35 J-36  J-37 J-38 J-39 J-40  J-41 J-42 J-43 J-44  J-45 J-46 J-47 J-48  J-49 J-50 J-51 J-52  J-53 J-54 J-55 J-56  J-57 J-58 J-59 J-60  J-61 J-62 J-63 J-64  J-69 J-70 J-71 J-72  J-73 J-74 J-75 J-76  J-77 J-78 J-79 J-80  J-81 J-82 Q is one of Q-I through Q- 102  Q-I Q-2 Q-3 Q-4  Q-5 Q-6 Q-7 Q-8  Q-9 Q-IO Q-I l Q-12  Q-13 Q-14 Q-15 Q-16  Q-17 Q-18 Q-19 Q-20  Q-21 Q-22 Q-23 Q-24  Q-25 Q-26 Q-27 Q-28  Q-29 Q-30 Q-31 Q-32  Q-33 Q-34 Q-35 Q-36 Q-37 Q-38 Q-39 Q-40 Q-41 Q-42 Q-43 Q-44  Q-45 Q-46 Q-47 Q-48  Q-49 Q-50 Q-51 Q-52  Q-56 Q-57 Q-58  Q-59 Q-60 Q-61  Q-62 Q-63 Q-64  Q-65 Q-66 Q-67  Q-68 Q-69 Q-70  Q-71 Q-72 Q-73  Q-74 Q-75 Q-76  Q-77 Q-78 Q-79  Q-83 Q-84 Q-85  Q-86 Q-87 Q-ϊ  Q-89 Q-90 Q-91 Q-92 Q-93 Q-94  Q-95 Q-96 Q-97  Q-IOl Q- 102 R1is one of U-I through U-50  U-I U-2 U-3 U-4  U-5 U-6 U-7 U-8  U-9 U-IO U-I l U-12  U-13 U-14 U-15 U-16 /(TR.44-)k  U-21 U-22 U-23 U-24  U-25 U-26 U-27 U-28  U-29 U-30 U-31 U-32  U-33 U-34 U-35 U-36  U-45 U-46 U-47 U-48  U-49 U-50 each R2is independently methyl, methoxy, cyano or hydroxy; each R3ais independently selected from H and R3; each R5is independently H, cyano, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C8cycloalkyl, C3-C8halocycloalkyl, C4-C10alkylcycloalkyl, C4-C10cycloalkylalkyl, C2-C6alkoxyalkyl, C4-C10cycloalkoxyalkyl, C3-C8alkoxyalkoxyalkyl, C2-C6alkylthioalkyl, C2-C6alkoxycarbonyl, C1-C6alkoxy, C1-C6haloalkoxy, C3-C8cycloalkoxy, C3-C8halocycloalkoxy, C4-C10cycloalkylalkoxy, C2-C6alkenyloxy, C2-C6haloalkenyloxy, C2-C6alkynyloxy, C2-C6haloalkynyloxy, C2-C6alkoxyalkoxy, C2-C6alkylcarbonyloxy, C2-C6haloalkylcarbonyloxy, C4-C8cycloalkylcarbonyloxy, C3-C6alkylcarbonylalkoxy, C1-C6alkylthio, C1- C6haloalkylthio, C3-C8cycloalkylthio, C3-C10trialkylsilyl, -NR25R26or Z2Q; R1 lais selected from H and R11; R15is H, cyano, hydroxy, methyl or methoxycarbonyl; or R15is C2-C3alkenyloxy, C2-C3alkynyloxy, C2-C3alkylcarbonyloxy, C2-C3alkoxycarbonyloxy,C2-C3haloalkylcarbonyloxy, C2-C3haloalkoxycarbonyloxy, C2-C3alkylaminocarbonyloxy, C3-C4dialkylaminocarbonyloxy, C2-C3haloalkylaminocarbonyloxy, C3-C4halodialkylaminocarbonyloxy, C2-C3alkoxyalkoxy, C2-C3haloalkoxyalkoxy, C1-C3alkylsulfonyloxy, C1-C3haloalkylsulfonyloxy or C3-C6trialkylsilyloxy; R16is H, methyl, methylcarbonyl or methoxycarbonyl; each Z4is C(=O); k is 0, 1 or 2; p is 0, 1, 2 or 3; and x is an integer from 0 to 5; provided that: (i) when R4is attached to a carbon ring member, said R4is selected from R4a; (ii) when R4is attached to a nitrogen ring member, said R4is selected from R4^; (iii) when G is G-6, G-16 or G-42, and each R3ais other than H, then R1 lais H; (iv) when G is G-25 or G-31 , then at least one R3ais H; and (v) when G is one of G-31 through G-35, then Z1is a direct bond or CHR20 . 4. The composition of Claim 3 wherein component (a) is a compound of Formula 1 lt thereof, wherein G is selected from G-I, G-2, G-7, G-8, G-14, G-15, G-23, G-24, G-26, G-27, G-36, G- 37, G-38, G-49, G-50 and G-55; J is selected from J-I, J-2, J-3, J-4, J-5, J-7, J-8, J-9, J-10, J-I l, J-12, J-14, J-15, J-16, J-20, J-24, J-25, J-26, J-29, J-30, J-37, J-38, J-45 and J-69; each Q is independently Q-I, Q-20, Q-32 through Q-34, Q-45 through Q-47, Q-60 through Q-73, Q-76 through Q-79, Q-84 through Q-94 and Q-98 through Q- 102; A is CH2or NH; W is O; X iS Xi5X2Or X3; each R5is independently H, cyano, C1-C6alkyl, C1-C6haloalkyl, C3-Cg cycloalkyl, C3-C8halocycloalkyl, C2-C6alkoxyalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C3-Cg cycloalkoxy, C2-C6alkenyloxy, C2-C6haloalkenyloxy, C2-C6alkynyloxy, C2-C6alkoxyalkoxy, C2-C6alkylcarbonyloxy, C2-C6haloalkylcarbonyloxy, C1-C6alkylthio, C1-C6halo alky lthio, C3-C1Q trialkylsilyl, -NR25R26or Z2Q; Z1is a direct bond; Z2is a direct bond or NR21; R1is selected from U-I through U-3, U-I l, U-13, U-20, U-22, U-23, U-36 through U- 39 and U-50; each R3is independently methyl or halogen; each R4ais independently C1-C2alkyl, C1-C2haloalkyl, halogen, C1-C2alkoxy or C1-C2haloalkoxy; each R4bis independently C1-C2alkyl or C1-C2haloalkyl; each R7is independently halogen, cyano, C1-C3alkyl, C1-C3haloalkyl, hydroxy, C1- C2alkoxy or C1-C2haloalkoxy; k is 1 or 2; and n is 0. 5. The composition of Claim 4 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein A is CH2; G is selected from G-I, G-2, G-15, G-26, G-27, G-36, G-37 and G-38; and G is unsubstituted; J is selected from J-4, J-5, J-8, J-I l, J-15, J-16, J-20, J-29, J-30, J-37, J-38, and J-69; Q is selected from Q-I, Q-45, Q-63, Q-64, Q-65, Q-68, Q-69, Q-70, Q-71, Q-72, Q-73, Q-76, Q-78, Q-79, Q-84, Q-85, Q-98, Q-99, Q-IOO, Q-IOl and Q-102; X is X1or X2; and the ring comprising X is saturated; R1is U-I or U-50; each R4ais independently C1-C2alkyl, trifluoromethyl, Cl, Br, I or methoxy; each R4b is independently C1-C2alkyl or trifluoromethyl; and each R5is independently H, cyano, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1- C6haloalkoxy, -NR25R26or Z2Q. 6. The composition of Claim 5 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein G is selected from G-I, G-2, G-15, G-26 and G-36; J is selected from J-4, J-5, J-I l, J-20, J-29, J-37, J-38, and J-69; Q is selected from Q-45, Q-63, Q-64, Q-65, Q-68, Q-69, Q-70, Q-71, Q-72 and Q-85; and X is X1. 7. The composition of Claim 1 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein R1is an optionally substituted phenyl or 5- or 6-membered heteroaromatic ring; A is CH2or NH; X is X1, X2, X3, X4, X5, X6, X7or X8; each R2is independently C1-C4alkyl, C1-C4alkenyl, C1-C4haloalkyl, C1-C4alkoxy, halogen, cyano or hydroxy; or two R2are taken together as C1-C3alkylene or C2-C3alkenylene to form a bridged bicyclic ring system; or two R2attached to adjacent ring carbon atoms joined by a double bond are taken together as -CH=CH-CH=CH- optionally substituted with 1 to 3 substituents selected from C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, halogen, hydroxy, amino, cyano and nitro; G is an optionally substituted 5-membered heteroaromatic ring or 5-membered saturated or partially saturated heterocyclic ring; J is a 5- or 6-membered ring or a 8- to 11-membered bicyclic ring system, each ring or ring system containing ring members selected from carbon and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 3 N, and optionally including 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O), or S(O)2, each ring or ring system optionally substituted with 1 to 5 substituents independently selected from R5; each R5is independently H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C4-C10cycloalkylalkyl, C4-C10alkylcycloalkyl, C5-C10alkylcycloalkylalkyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio, C1-C6alkylsulfϊnyl, C1-C6alkylsulfonyl, C1-C6haloalkylthio, C1-C6haloalkylsulfϊnyl, C1-C6haloalkylsulfonyl, C1-C6alkylamino, C2-Cg dialkylamino, C3-C6cycloalkylamino, C2-C6alkoxyalkyl, C2-C6haloalkoxyalkyl, C1-C6hydroxyalkyl, C2-C6alkylcarbonyl, C2-C6alkoxycarbonyl, C2-C6alkylcarbonyloxy, C2-C6alkylcarbonylthio, C2-C6alkylaminocarbonyl, C3-Cg dialkylaminocarbonyl, C3-C6trialkylsilyl, or -Z2Q; each Q is independently an optionally substituted phenyl, benzyl, naphthalenyl, C3-C6cycloalkyl, C3-C6cycloalkenyl or 5- or 6-membered heteroaromatic ring, each optionally substituted with 1 to 3 substituents selected from R7on carbon ring members and R12on nitrogen ring members; each R7is independently C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C4-C1Ocycloalkylalkyl, C4-C1Oalkylcycloalkyl, C5-Q0alkylcycloalkylalkyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C1-C4alkoxy, C1-C4haloalkoxy, C1-C4alkylthio, C1-C4alkylsulfmyl, C1-C4alkylsulfonyl, C1-C4haloalkylthio, C1-C4haloalkylsulfinyl, C1-C4haloalkylsulfonyl, C1-C4alkylamino, C2-Cg dialkylamino, C3-C6cycloalkylamino, C2-C4alkoxyalkyl, C1-C4hydroxyalkyl, C2-C4alkylcarbonyl, C2-C6alkoxycarbonyl, C2-C6alkylcarbonyloxy, C2-C6alkylcarbonylthio, C2-C6alkylaminocarbonyl, C3-Cg dialkylaminocarbonyl or C3-C6trialkylsilyl; or R5and R7are taken together with the atoms linking R5and R7to form an optionally substituted 5- to 7-membered ring containing as ring members 2 to 7 carbon atoms and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 1 N; R12is C1-C3alkyl; each Z1and Z2are independently a direct bond, O, S(O)m, CHR20or NR21; and R21is H or C1-C3alkyl. 8. The composition of Claim 7 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein G is a 5-membered heteroaromatic ring or 5-membered saturated or partially saturated heterocyclic ring, each ring optionally substituted with up to 2 substituents selected from R3on carbon ring members and selected from R11on nitrogen ring members; R1is a phenyl or 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 2 substituents independently selected from R4aon carbon ring members and R4b on nitrogen ring members; each R3is independently C1-C3alkyl, C1-C3haloalkyl or halogen; each R4ais independently C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C4-C1Ocycloalkylalkyl, C4-C1Oalkylcycloalkyl, C5-Q0alkylcycloalkylalkyl, C1-C6haloalkyl, C2-C6haloalkenyl, C2-C6haloalkynyl, C3-C6halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C1-C4alkoxy, C1-C4haloalkoxy, C1-C4alkylthio, C1-C4alkylsulfϊnyl, C1-C4alkylsulfonyl, C1-C4haloalkylthio, C1-C4haloalkylsulfϊnyl, C1-C4haloalkylsulfonyl, C1-C4alkylamino, C2~Cg dialkylamino, C3-C6cycloalkylamino, C2~C4alkoxyalkyl, C1-C4hydroxyalkyl, C2~C4alkylcarbonyl, C2~C6alkoxycarbonyl, C2~C6alkylcarbonyloxy, C2~C6alkylcarbonylthio, C2~C6alkylaminocarbonyl, C3-Cg dialkylaminocarbonyl or C3-C6trialkylsilyl; each R4b is independently C1-C6alkyl, C3-C6alkenyl, C3-C6alkynyl, C3-C6cycloalkyl, C1-C6haloalkyl, C3-C6haloalkenyl, C3-C6haloalkynyl, C3-C6halocycloalkyl or C2~C4alkoxyalkyl; each R11is independently C1-C3alkyl; and when R5and R7are taken together with the atoms linking R5and R7to form an optionally substituted 5- to 7-membered ring, then R5and R7are taken together with the atoms linking R5and R7to form a 5- to 7-membered ring containing as ring members 2 to 7 carbon atoms and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 1 N, optionally substituted with up to 2 substituents selected from R8; and each R8is independently C1-C3alkyl. 9. The composition of Claim 8 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein G is one of G-I through G-55 as defined in Claim 3; J is one of J-I through J-82 as defined in Claim 3; Q is one of Q-I through Q-55 as defined in Claim 3; R1is one of U-I through U-50 as defined in Claim 3; each R3ais independently selected from H and R3; R1 lais selected from H and R11; k is 0, 1 or 2; p is 0, 1 or 2; and x is an integer from 0 to 5; provided that: (i) when R4is attached to a carbon ring member, said R4is selected from R4a; (ii) when R4is attached to a nitrogen ring member, said R4is selected from R4^; (iii) when G is G-6, G- 16 or G-42, and each R3ais other than H, then R1 lais H; (iv) when G is G-25 or G-31 , then at least one R3ais H; and (v) when G is one of G-31 through G-35, then Z1is a direct bond or CHR20. 10. The composition of Claim 9 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein G is selected from G-I, G-2, G-15, G-26, G-27, G-36, G-37 and G-38; J is selected from J-I, J-2, J-3, J-4, J-5, J-7, J-8, J-9, J-IO, J-I l, J-12, J-14, J-15, J-16, J-20, J-24, J-25, J-26, J-29, J-30, J-45 and J-69; each Q is independently Q-I, Q-20, Q-32 to 34, Q-45 Q-46 or Q-47; W is O; X iS Xi5X2Or X3; each Z1and Z2is a direct bond; R1is selected from U-I through U-3, U-I l, U-13, U-20, U-22, U-23, U-36 through U- 39 and U-50; each R3is independently methyl or halogen; each R4ais independently C1-C2alkyl, C1-C2haloalkyl, halogen or C1-C2alkoxy; each R4bis independently C1-C2alkyl or C1-C2haloalkyl; one instance of R5is Z2Q and other instances of R5are independently selected from H, C1-C4alkyl, C1-C4haloalkyl and halogen; each R7is independently halogen, C ^C3alkyl, C ^C3haloalkyl, hydroxy, C1-C2alkoxy or C1-C2haloalkoxy; k is 1 or 2; and n is 0. 11. The composition of Claim 10 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein A is CH2; G is selected from G-I, G-2, G-15, G-26, and G-36; and G is unsubstituted; J is selected from J-I l, J-25, J-26, J-29 and J-30; Q is selected from Q-I and Q-45; X is X1or X2; and the ring comprising X is saturated; R1is U-I or U-50; each R4ais independently C1-C2alkyl, trifluoromethyl, Cl, Br, I or methoxy; and each R4b is independently C1-C2alkyl or trifluoromethyl. 12. The composition of Claim 11 wherein component (a) is a compound of Formula 1 or a salt thereof, wherein J is selected from J-I l and J-29; X is X1; and each R4ais independently C1-C2alkyl, trifluoromethyl or Cl. 13. The composition of Claim 1 wherein component (a) is selected from the group consisting of 4-[4-[(5i?)-4,5-dihydro-5-phenyl-3-isoxazolyl]-2-thiazolyl]-l-[[5-methyl-3- (trifluoromethyl)-lH-pyrazol-l-yl]acetyl]piperidine and its enantiomer, l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-4-[4-(5-phenyl-3- isoxazolyl)-2-thiazolyl]piperidine, 1 - [4-[4- [(5R)-4,5 -dihydro-5 -methyl-5 -pheny 1-3 -isoxazolyl] -2-thiazolyl] - 1 - piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, 2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]-l-[4-[4-[(3alS,9bi?),3a,4,5,9b- tetrahydronaphth[2, 1 -<i]isoxazol-3-yl]-2-thiazolyl]- 1 -piperidinyl] ethanone and its enantiomer, 1 - [4-[4- [(5R)-4,5 -dihydro-5 -phenyl-3 -isoxazolyl] -2-thiazolyl]- 1 -piperidinyl] -2- [5 - ethyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, 2-[3,5-bis(trifluoromethyl)- lH-pyrazol- 1 -yl]- 1 -[4-[4-[(5i?)-4,5-dihydro-5-phenyl-3- isoxazolyl] -2-thiazolyl] -1 -piperidinyl] ethanone and its enantiomer, l-[4-[4-[(5i?)-3',4>-dihydrospiro[isoxazole-5(4H),r,(2>H)-naphthalen]-3-yl]-2- thiazolyl]- 1 -piperidinyl]-2-[5-methyl-3-(trifluoromethyl)- lH-pyrazol-1 -yl]ethanone and its enantiomer, l-[4-[4-[(5i?)-2,3-dihydrospiro[lH-indene-l,5'(4>H)-isoxazol]-3>-yl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, 2-[5-chloro-3-(trifluoromethyl)- lH-pyrazol-1 -yl]- 1 -[4-[4-[(5i?)-4,5-dihydro-5- phenyl-3-isoxazoly]-2-thiazolyl]-l-piperidinyl]ethanone and its enantiomer, 2-[(5i?)-4,5-dihydro-3-[2-[l-[2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-4-thiazolyl-5-isoxazolyl]- lH-isoindole- 1 ,3(2H)-dione and its enantiomer, 2-[5-chloro-3-(trifluoromethyl)- lH-pyrazol-1 -yl]- 1 -[4-[4-[(li?)-2,3-dihydrospiro[ IH- indene- 1 ,5'(4'H)-isoxazol]-3'-yl]-2-thiazolyl]- 1 -piperidinyl]ethanone and its enantiomer, 2-[5-chloro-3-(trifluoromethyl)-lH-pyrazol-l-yl]-l-[4-[4-[(ri?)-3',4>- dihydrospiro[isoxazole-5(4H), 1?(2'H)-naphthalen] -3 -yl] -2-thiazolyl] - 1 - piperidinyl]ethanone and its enantiomer, 2-[5 -methyl-3 -(trifluoromethyl)- lH-pyrazol- 1 -yl] - 1 - [4-[4-(3i?)-spiro [benzofuran- 3(2H),5'(4'H)-isoxazol]-3'-yl-2-thiazolyl]-l-piperidinyl]ethanone and its enantiomer, l-[4-[4-[(li?)-2,3-dihydrospiro[lH-indene-l,5'(4>H)-isoxazol]-3'-yl]-2-thiazolyl]-l- piperidinyl-2-(3,5-dimethyl-lH-pyrazol-l-yl)ethanone and its enantiomer, 2-[3,5-bis(trifluoromethyl)-li?-pyrazol-l-yl]-l-[4-[4-[(lIR)-3I,4I- dihydrospiro[isoxazole-5(4H), 1 '(2'H)-naphthalen]-3-yl]-2-thiazolyl]- 1 - piperidinyljethanone and its enantiomer, 2-[3,5-bis(trifluoromethyl)- lH-pyrazol- 1 -yl]- 1 -[4-[4-[(li?)-2,3-dihydrospiro[lH- indene- 1 ,5'(4'H)-isoxazol]-3'-yl]-2-thiazolyl]- 1 -piperidinyljethanone and its enantiomer, l-[4-[4-[(5i?)-5-(2,6-dichlorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, l-[4-[4-[(5i?)-4,5-dihydro-5-(2-fluorophenyl)-3-isoxazolyl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, l-[4-[4-[(5i?)-4,5-dihydro-5-(2-methylphenyl)-3-isoxazolyl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, l-[4-[4-[(5i?)-5-(2,6-dimethylphenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, l-[4-[4-[(5i?)-4,5-dihydro-5-(2,4,6-trimethylphenyl)-3-isoxazolyl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, l-[4-[4-[(ri?)-3>,4>-dihydrospiro[isoxazole-5(4H),r(2'H)-naphthalen]-3-yl]-2- thiazolyl]-l-piperidinyl]-2-(3,5-dimethyl-lH-pyrazol-l-yl)ethanone and its enantiomer, l-[4-[4-[(5i?)-4,5-dihydro-5-(2,4,6-trimethoxyphenyl)-3-isoxazolyl]-2-thiazolyl]-l- piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]ethanone and its enantiomer, 3-[(5i?)-4,5-dihydro-3-[2-[l-[2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-4-thiazolyl]-5-isoxazolyl]-2(3H)-benzoxazolone and its en(...)
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type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=US     Event publication date=2016-11-17  Event code=US/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=US  LEGAL DETAILS FOR DESIGNATED STATE VN24622  Actual or expected expiration date=2028-10-23    Legal state=ALIVE    Status=GRANTED   Corresponding cc:  Designated or member state=VN Corresponding appl: VN201001286  Application date in the designated or member state=2008-10-23   Application number in the designated or member state=2010VN-1001286 Corresponding cc:  Designated or member state=VN Corresponding pat: VN24622  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2010-12-27   Publication number in the designated or member state=VN--24622    Event publication date=2018-02-26  Event code=VN/STCHG  Patent Status changed by the national office 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