Process for the preparation of the L-arginine salt of perindopril 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
EP2612851 B1 2016-07-06 [EP2612851]EP2612851 A1 2013-07-10 [EP2612851] / 2016-07-062013-07-10
申请号/申请日
2013EP-0150305 / 2013-01-04
发明人
LINOL JULIE;LAURENT STÉPHANE;GRENIER ARNAUD;MATHIEU SÉBASTIEN;
申请人
SERVIER;
主分类号
IPC分类号
C07D-209/42
摘要
(EP2612851) Preparing perindopril L-arginine salt (I) comprises reacting perindopril and L-arginine in a solvent system comprising a binary mixture of acetonitrile and dimethyl sulfoxide, a binary mixture of ethyl acetate and dimethyl sulfoxide, and a ternary mixture of acetonitrile, dimethyl sulfoxide and toluene, at a temperature of 10-100[deg] C; and isolating (I) by filtration.  ACTIVITY : Cardiovascular-Gen.; Hypotensive; Cardiant; Vasotropic.  MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2012FR-0000034 2012-01-05
主权利要求
(EP2612851) 1. Method of preparation of the salt of [L]-arginine of the [perindopril], formula (I): by reaction enters the [perindopril] and [L]-arginine a solvent system chosen among: a binary mixture of [acetonitrile] and [dimethylsulfoxyde], a binary mixture of acetate of ethyl and [dimethylsulfoxyde], a ternary mixture of [acetonitrile], [dimethylsulfoxyde] and toluene, at a temperature of 10 with 100.deg.C, followed by insulation by filtration of the salt of [L]-arginine thus obtained.
法律状态
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专利类型码
B1A1
国别省市代码
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