Methods and compositions for cancer therapy 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2007213285 A1 2007-09-13 [US20070213285]US7807647 B2 2010-10-05 [US7807647] / 2007-09-132010-10-05
申请号/申请日
2005US-11233312 / 2005-09-22
发明人
SHEIKHNEJAD GHOLAMREZA;GOODWIN NEAL;OLSON DAVID;
申请人
PRONAI THERAPEUTICS;
主分类号
IPC分类号
A01N-043/04A61K-031/70C12N-005/00C12N-005/02C12N-015/00
摘要
(US7807647) The present invention relates to methods and compositions for the inhibition of gene expression.  In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2004US-10858164 2004-06-01 2004US-60611974 2004-09-22 2005US-11233312 2005-09-22
主权利要求
(US7807647) We claim: 1.  A method for reducing tumor burden in a subject, wherein said method comprises: parenterally administering: an antigene oligonucleotide comprising SEQ ID NO:1438 to said subject   wherein said subject exhibits symptoms of cancer,    wherein said cancer is selected from prostate cancer, breast cancer, lymphoma, and leukemia. 2. The method of claim 1, wherein said administering results in a reduction in symptoms of cancer in said subject. 3. The method of claim 1, wherein said cancer is a prostate cancer. 4. The method of claim 1, wherein said subject is a non-human mammal. 5. The method of claim 1, wherein said subject is a human. 6. The method of claim 1, wherein said oligonucleotide is introduced to said subject at a dosage of between 1 mg to 100 mg per kg of body weight. 7. The method of claim 1, further comprising the step of administering a known chemotherapeutic agent to said subject. 8. The method of claim 7, wherein said known chemotherapeutic agent is docetaxel. 9. The method of claim 1, further comprising providing a drug delivery system for introducing said oligonucleotide to said subject. 10. The method of claim 9, wherein said drug delivery system comprises a liposome, said liposome selected from the group consisting of a neutral lipid and a lipid like compound. 11. The method of claim 9, wherein said drug delivery system comprises a liposome, said liposome comprising a cationic lipid. 12. The method of claim 1, wherein said cancer is selected from breast cancer, lymphoma, and leukemia. 13. The method of claim 1, wherein said cancer is selected from lymphoma.
法律状态
(US7807647) LEGAL DETAILS FOR US2007213285  Actual or expected expiration date=2026-08-23    Legal state=ALIVE    Status=GRANTED     Event publication date=2005-09-22  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US11233312  Application date=2005-09-22  Standardized application number=2005US-11233312     Event publication date=2005-09-22  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: EPPS -SMITH, JANET L    Event publication date=2005-09-22  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1633     Event publication date=2005-09-22  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status Business Entity Status: SMALL    Event publication date=2005-09-22  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2005-09-22  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 31899-28537/US    Event publication date=2005-09-22  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 758    Event publication date=2005-10-28  Event code=US/INCD  Event type=Examination events  Event type=OAO  Notice Mailed--Application Incomplete--Filing Date Assigned    Event publication date=2006-02-02  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: PRONAI THERAPEUTICS, INC., MICHIGAN ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:SHEIKHNEJAD, GHOLAMREZA GOODWIN, NEAL OLSON, DAVID SIGNING DATES FROM 20060117 TO 20060124 REEL/FRAME:017526/0554     Event publication date=2006-02-02  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: PRONAI THERAPEUTICS, INC., MICHIGAN ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:SHEIKHNEJAD, GHOLAMREZA GOODWIN, NEAL OLSON, DAVID REEL/FRAME:017526/0554 SIGNING DATES FROM 20060117 TO 20060124     Event publication date=2006-02-02  Event code=US/APE  Event type=Corrections  Preliminary amendments    Event publication date=2006-06-20  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2006-12-08  Event code=US/APE  Event type=Corrections  Preliminary amendments    Event publication date=2007-07-23  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2007-08-17  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2007-09-13  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2007213285  Publication stage Code=A1  Publication date=2007-09-13  Standardized publication number=US20070213285     Event publication date=2007-09-13  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2008-03-06  Event code=US/AINEA  Event type=OAI  Event type=Examination events  Informal or Non-Responsive Amendment after Examiner Action    Event publication date=2008-03-06  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2008-03-06  Event code=US/136G  Event type=OAO  Request for Extension of Time - 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Granted    Event publication date=2010-01-25  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2010-04-23  Event code=US/PET  Event type=APL  Petition Entered    Event publication date=2010-04-27  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2010-09-15  Event code=US/PAT  Event indicator=Pos  Event type=Event indicating In Force  Patented Case    Event publication date=2010-09-15  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=2010-10-05  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US7807647  Publication stage Code=B2  Publication date=2010-10-05  Standardized publication number=US7807647     Event publication date=2010-10-05  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 1031  Overlap Delays: 0  Non Overlap Delays: 1031   PTO Office Delays: 0  Applicant Delays: 696  Adjustment total:  Number of days of extension=335    Event publication date=2013-10-15  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=3     Event publication date=2014-03-05  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2014-03-05     Year of payment of annual fees=4     Event publication date=2015-03-10  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2017-10-17  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=7
专利类型码
A1B2
国别省市代码
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