包含​生物防治​剂​和​选自​脂​质​膜​合成​抑制剂、黑素​生物​合成​抑制剂、核酸​合成​抑制剂​或​信号​转导​抑制剂​的​杀真菌​剂​的​组合​物

源语言标题
(CN104507319B) 包含​生物防治​剂​和​选自​脂​质​膜​合成​抑制剂、黑素​生物​合成​抑制剂、核酸​合成​抑制剂​或​信号​转导​抑制剂​的​杀真菌​剂​的​组合​物
公开号/公开日
CN104507319 A 2015-04-08 [CN104507319]CN104507319 B 2018-08-03 [CN104507319B] / 2015-04-082018-08-03
申请号/申请日
2013CN-80040576 / 2013-05-29
发明人
WACHENDORFF-NEUMANN ULRIKE;ANDERSCH WOLFRAM;STENZEL KLAUS;SPRINGER BERND;
申请人
BAYER CROPSCIENCE;
主分类号
IPC分类号
A01N-037/46A01N-043/36A01N-047/12A01N-063/00A01P-003/00
摘要
(CN104507319B) 本​发明​涉及​包含​协同​有效​量​的​至少​种​生物防治​剂​和​至少​种​杀真菌​剂(I)的​组合​物,所​述​生物防治​剂​选自:角质​孢子​芽孢​菌(Bacillus chitinosporus)AQ746(NRRL​登录​号​B‑21618)、蕈​状​芽孢​杆菌(Bacillus mycoides)AQ726(NRRL​登录​号​B‑21664)、短小​芽孢​杆菌(Bacillus pumilus)(NRRL​登录​号​B‑30087)、短小​芽孢​杆菌(Bacillus pumilus)AQ717(NRRL​登录​号​B‑21662)、芽孢​杆菌​属(Bacillus sp.)AQ175(ATCC​登录​号​55608)、芽孢​杆菌​属(Bacillus sp.)AQ177(ATCC​登录​号​55609)、芽孢​杆菌​属​种(Bacillus sp.)AQ178(ATCC​登录​号​53522)、枯草​芽孢​杆菌(Bacillus subtilis)AQ743(NRRL​登录​号​B‑21665)、枯草​芽孢​杆菌(Bacillus subtilis)AG713(NRRL​登录​号​B‑21661)、枯草​芽孢​杆菌(Bacillus subtilis)AQ153(ATCC​登录​号​55614)、苏​云​金​芽孢​杆菌(Bacillus thuringiensis)BD#32(NRRL​登录​号​B‑21530)、苏​云​金​芽孢​杆菌(Bacillus thuringiensis)AQ52(NRRL​登录​号​B‑21619)、白色​产​气​霉(Muscodor albus)620(NRRL​登录​号​30547)、粉红​产​气​霉(Muscodor roseus)A3‑5(NRRL​登录​号​30548)、球状​红​球菌(Rhodococcus globerulus)AQ719(NRRL​登录​号​B‑21663)、鲜​黄​链​霉菌(Streptomyces galbus)(NRRL​登录​号​30232)、链​霉菌​属(Streptomyces sp.)(NRRL​登录​号​B‑30145)、苏​云​金​芽孢​杆菌​库尔斯塔克亚​种(Bacillus thuringiensis subspec.kurstaki)BMP 123、枯草​芽孢​杆菌(Bacillus subtilis)AQ30002(NRRL​登录​号​B‑50421)和​枯草​芽孢​杆菌(Bacillus subtilis)AQ30004(NRRL​登录​号​B‑50455),和/或​这些​菌株​的​具有​各自​菌株​的​所有​鉴定​特征​的​突变​体​和/或由​各自​菌株​产生​的​表现​出​抗​昆虫、螨虫、线虫​和/或​植物病​原体​的​活性​的​代谢物;所​述​杀真菌​剂(I)选自​脂​质​膜​合成​抑制剂、黑色素​生物​合成​抑制剂、核酸​合成​抑制剂、信号​转导​抑制剂​和​能够​作为​解​偶​联​剂​的​化合物。此外,本​发明​涉及​该​组合​物​的​用途,以及​用于​降低​植物​和​植物​部位​的​总体​损害​的​方法。
地址
代理人
代理机构
;
优先权号
2012EP-0004160 2012-05-30 2012EP-0197941 2012-12-19 2013WO-EP61020 2013-05-29
主权利要求
(CN104507319B) 1. A composition, comprising synergistically effective amount of one biological control agent and at least one fungicide (I), Biological control agent is Bacillus subtilis AQ30002 (NRRL Accession No. B-50421); A fungicide (I) is selected from methane cream spirit, efficient cream spirit (mefenoxam), propamocarb-HCl and fludioxonil; Wherein the biological control agent and a fungicide (I) a synergistic weight ratio in the range of 1:1 to 1:0 .01. 2. Composition according to claim 1, wherein the biological control agent and a fungicide (I) a synergistic weight ratio ranges from 1:0 .1 to 1:0 .9. 3. Composition according to claim 1, wherein the biological control agent and a fungicide (I) a synergistic weight ratio of 1:0 .2 or 1:0 .8. 4. Composition according to claim 1, wherein the fungicides (I) to formic cream spirit and the biological control agent and a fungicide (I) a synergistic weight ratio of 1:0 .2. 5. Composition according to claim 1, wherein the fungicides (I) for effectively cream spirit (mefenoxam) and the biological control agent and a fungicide (I) a synergistic weight ratio of 1:0 .2. 6. Composition according to claim 1, wherein the fungicides (I) - HCl and the biological control agent and a fungicide to the propamocarb (I) a synergistic weight ratio of 1:0 .8. 7. Composition according to claim 1, wherein the fungicides (I) triflumuron as biological control agent and a fungicide (I) a synergistic weight ratio of 1:0 .2 or 1:0 .02. 8. A composition according to any one of claim 1 to 7, further comprising at least one additional fungicide (II), with the proviso that the biological control agent, fungicides (I) and a fungicide (II) are not the same. 9. Composition according to claim 8, wherein a fungicide (II) syntiietic fungicides. 10. Composition according to claim 8, wherein a fungicide (II) is selected from: Ergosterol biosynthesis inhibitors, respiratory chain complex II inhibitor I or, respiratory chain complex III inhibitors, mitosis and cell division inhibitors, can have the effect of a multi-site, a compound capable of inducing host defense, amino acids and/or protein biosynthesis inhibitor, ATP production inhibitors, cell wall synthesis inhibitors, lipid and membrane synthesis inhibitor, melanin biosynthesis inhibitors, nucleic acid synthesis inhibitors, signal transduction inhibitors, capable of acting as uncoupler compounds. 11. Composition according to claim 8, wherein a fungicide (II) selected from the group: benzene thiophene thiocyanate, 3-benzo [b] thiophene-5, 6-dihydro-1, 4, 2-thiazine 4 - -2-based oxide, kaba xi neomycin, carvone, kinomethionate, pyriofenone,chlazafenone, sulfur miscellaneous ling, cyflufenamid, cymoxanil, p-cymene sulfonamide, dazomet, debacarb, dichlorophen, diclomezine, difenzoquat, difenzoquat methyl sulfate, diphenylamine, ecomate, amine benzene pyridine cycloheximide, fluoro-biphenyl bacteria, azole furosemide grass, flusulfamide, fluoro thiabendazole, acetic acid aluminum, calcium fosetyl, fosetyl sodium, hexachlorobenzene, irumamycin, methasulfocarb, methyl isothiocyanate, metrafenone, off powder neomycin, natamycin, the action of Mail nickel, bacteria phthalate ester, octhilinone, oxamocarb, austrian shi kangding, pentachlorophenol and its salts, phenothrin, phosphoric acid and its salts, propamocarb fosetyl acid salt, sodium cyclosporin propanol, propoxy-quinoline, topiramate morpholine, (2 E) -3 - (4-tert-butyl phenyl) -3 - (2-chloro pyridine -4-yl) -1 - (morpholine -4-yl) propanoic -2-ene -1-ketone, (2 Z) -3 - (4-tert-butyl phenyl) -3 - (2-chloro pyridine -4-yl) -1 - (morpholine -4-yl) propanoic -2-ene -1-ketone, pyrrole nitrendipine, iso-butyl arylethoxy quinoline, tecloftalam, a flusulfamide, imidazole hydrochloride, Trichlamide, fenoxanil, (3 S, 6 S, 7 R, 8 R) -8-benzyl -3 - [( {3 - [(lsobutyryloxy) methoxy] -4-methoxypyridin -2-yl} carbonyl) amino] - 4, 9-dioxo-1, 5-2-methyl -6-wang dioxide ring methypropanoate -7-yl, 1 - (4 - {4 - [(5 R) -5 - (2, 6-difluorophenyl) - 4, 5-dihydro-1, 2-oxazol -3-yl] - 1, 3-thiazol -2-yl} piperidine -1-yl) -2 - [5-methyl -3 - (trifluoromethyl) - 1H - pyrazol -1-yl] ethyl ketone, 1 - (4 - {4 - [(5 S) -5 - (2, 6-difluorophenyl) - 4, 5-dihydro-1, 2-oxazol -3-yl] - 1, 3-thiazol -2-yl} piperidine -1-yl) -2 - [5-methyl -3 - (trifluoromethyl) - 1H - pyrazol -1-yl] ethyl ketone, 1 - (4 - {4 - [5 - (2, 6-difluorophenyl) - 4, 5-dihydro-1, 2-oxazol -3-yl] - 1, 3-thiazol -2-yl} piperidine -1-yl) -2 - [5-methyl -3 - (trifluoromethyl) - 1H - pyrazol -1-yl] ethyl ketone, 1 - (4-methoxyphenoxy) - 3, 3-dimethylbutan -2-1 H - imidazole -1-carboxylic acid ester group, 2, 3, 5, 6-tetrachloro -4 - (methylsulfonyl) pyridine, 2, 3-dibutyl -6-chlorothieno [2, 3-d] pyrimidin -4 (3 H) - ketone, 2, 6-dimethyl-1H, 5 H - [1, 4] disulfide hexane [2, 3-c: 5, 6-c '] dipyrrole-1, 3, 5, 7 (2 H, 6 H) - tetrone, 2-[5-methyl-3-(trifluoromethyl) -1 H-pyrazol-1-yl]-1-(4-{4-[(5 R) -5-phenyl-4, 5-dihydro-1, 2-oxazol-3-yl]-1, 3-thiazol-2-yl} piperidine-1-yl) ketone, 2-[5-methyl-3-(trifluoromethyl) -1 H-pyrazol-1-yl]-1-(4-{4-[(5 S) -5-phenyl-4, 5-dihydro-1, 2-oxazol-3-yl]-1, 3-thiazol-2-yl} piperidine-1-yl) ETHANONE, 2-[5-methyl-3-(trifluoromethyl) -1 H-pyrazol-1-yl]-1-{4-[4-(5-phenyl-4, 5-dihydro-1, 2-oxazol-3-yl) -1, 3-thiazol-2-yl] piperidin-1-yl} ethyl ketone, 2-butoxy-6-iodo-3-propyl-4 H-benzo pyran-4-ketone, 2-chloro-5-[2-chloro-1-(2, 6-difluoro-4-methoxyphenyl) -4-methyl-1 H-imidazol-5-yl] pyridine, 2-phenyl phenol and its salts, 3-(4, 4, 5-trifluoro-3, 3-dimethyl-3, 4-dihydroisoquinoline-1-yl) quinoline, 3, 4, 5-trichloro pyridine-2, 6-aciddinitrile, 3-[5-(4-chlorophenyl) -2, 3-dimethyl-1, 2-oxazolidine-3-yl] pyridine, 3-chloro-5-(4-chlorophenyl) -4-(2, 6-difluorophenyl) -6-methylpyhdazine, 4-(4-chlorophenyl) -5-(2, 6-difluorophenyl) -3, 6-dimethyl pyridazine, 5-amino-1, 3, 4-thiadiazole-2-thiol, 5-chloro-N'-phenyl-N'-(prop-2-alkyne-1-yl) thiophen-2-sulfonyl hydrazides, 5-fluoro-2-[(4-fluorobenzyl) oxy] pyrimidine-4-amine, 5-fluoro-2-[(4-methyl benzyl) oxy] pyrimidine-4-amine, 5-methyl-6-octyl [1, 2, 4] triazolo [1, 5-a] pyrimidine-7-amine, (2 Z) -3-amino-2-cyano-3-phenyl propionic-2-enoic acid ethyl ester, N '-(4-{[3-(4-chlorobenzyl) -1, 2, 4-thiadiazole-5-yl] oxy}-2, 5-dimethyl phenyl) -N-ethyl-N-methyl imide form amide, N-(4-chlorobenzyl) -3-[3-methoxy-4-(prop-2-alkyne-1-yloxy) phenyl] propionamide, N-[(4-chlorophenyl) (cyano) methyl]-3-[3-methoxy-4-(prop-2-alkyne-1-yloxy) phenyl] propanamide, N-[(5-bromo-3-chloro pyridine-2-yl) methyl]-2, 4-dichlopyridine-3-carboxamide, N-[1-(5-bromo-3-chloro pyridine-2-yl) ethyl]-2, 4-dichlopyridine-3-carboxamide, N-[1-(5-bromo-3-chloro pyridine-2-yl) ethyl]-2-fluoro-4-iodo pyridine-3-carboxamide, N-{(E) -[(cyclopropylmethoxy) imino] [6-(difluoromethoxy) -2, 3-DIFLUORO phenyl] methyl}-2-phenylacetamide, N-{(Z) -[(cyclopropylmethoxy) imino] [6-(difluoromethoxy) -2, 3-DIFLUORO phenyl] methyl}-2-phenylacetamide, N '-{4-[(3-tert-butyl-4-cyano-1, 2-thiazol-5-yl) oxy]-2-chloro-5-methyl phenyl}-N-ethyl-N-methyl imide form amide, N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl) -1 H-pyrazol-1-yl] acetyl} piperidin-4-yl) -N-(1, 2, 3, 4-tetrahydronaphalene-1-yl) -1, 3-thiazol-4-carboxamide, N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl) -1 H-pyrazol-1-yl] acetyl} piperidin-4-yl) -N-[(1 R) -1, 2, 3, 4-tetrahydronaphalene-1-yl]-1, 3-thiazol-4-carboxamide, N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl) -1 H-pyrazol-1-yl] acetyl} piperidin-4-yl) -N-[(1 S) -1, 2, 3, 4-tetrahydronaphalene-1-yl]-1, 3-thiazol-4-carboxamide, {6-[ ({[ (1-methyl-1 H-tetrazol-5-yl) (phenyl) methylidene] amino} oxy) methyl] pyridin-2-yl} amino pentyl formate, phenazine-1-carboxylic acid, quinoline-8-alcohol (134-31-6), quinoline-8-alcohol sulfate, {6-[ ({[ (1-methyl-1 H-tetrazol-5-yl) (phenyl) methylidene] amino} oxy) methyl] pyridin-2-yl} carbamate, 1-methyl-3-(trifluoromethyl) -N-[2'-(trifluoromethyl) biphenyl-2-yl]-1 H-pyrazol-4-carboxamide, N-(4 '-chloro biphenyl-2-yl) -3-(difluoromethyl) -1-methyl-1 H-pyrazol-4-carboxamide, N-(2', 4 '-dichloro biphenyl-2-yl) -3-(difluoromethyl) -1-methyl-1 H-pyrazol-4-carboxamide, 3-(difluoromethyl) -1-methyl-N-[4'-(trifluoromethyl) biphenyl-2-yl]-1 H-pyrazol-4-carboxamide, N-(2 ', 5'-difluorobiphenyl-2-yl) -1-methyl-3-(trifluoromethyl) -1 H-pyrazol-4-carboxamide, 3-(difluoromethyl) -1-methyl-N-[4 '-(prop-1-alkyne-1-yl) biphenyl-2-yl]-1 H-pyrazol-4-carboxamide, 5-fluoro-1, 3-dimethyl-N-[4'-(prop-1-alkyne-1-yl) biphenyl-2-yl]-1 H-pyrazol-4-carboxamide, 2-chloro-N-[4 '-(prop-1-alkyne-1-yl) biphenyl-2-yl] pyridin-3-carboxamide, 3-(difluoromethyl) -N-[4'-(3, 3-dimethyl butyl-1-alkyne-1-yl) biphenyl-2-yl]-1-methyl-1 H-pyrazol-4-carboxamide, N-[4 '-(3, 3-dimethyl butyl-1-alkyne-1-yl) biphenyl-2-yl]-5-fluoro-1, 3-dimethyl-1 H-pyrazol-4-carboxamide, 3-(difluoromethyl) -N-(4'-ethynyl biphenyl-2-yl) -1-methyl-1 H-pyrazol-4-carboxamide, n-(4 '-ethynyl biphenyl-2-yl) -5-fluoro-1, 3-dimethyl-1 H-pyrazol-4-carboxamide, 2-chloro-N-(4'-ethynyl biphenyl-2-yl) pyridin-3-carboxamide, 2-chloro-N-[4 '-(3, 3-dimethyl butyl-1-alkyne-1-yl) biphenyl-2-yl] pyridin-3-carboxamide, 4-(difluoromethyl) -2-methyl-N-[4'-(trifluoromethyl) biphenyl-2-yl]-1, 3-thiazol-5-carboxamide, 5-fluoro-N-[4 '-(3-hydroxy-3-methyibut-1-alkyne-1-yl) biphenyl-2-yl]-1, 3-dimethyl-1 H-pyrazol-4-carboxamide, 2-chloro-N-[4'-(3-hydroxy-3-methyibut-1-alkyne-1-yl) biphenyl-2-yl] pyridin-3-carboxamide, 3-(difluoromethyl) -N-[4 '-(3-methoxy-3-methyibut-1-alkyne-1-yl) biphenyl-2-yl]-1-methyl-1 H-pyrazol-4-carboxamide, 5-fluoro-N-[4'-(3-methoxy-3-methyibut-1-alkyne-1-yl) biphenyl-2-yl]-1, 3-dimethyl-1 H-pyrazol-4-carboxamide, 2-chloro-N-[4'-(3-methoxy-3-methyibut-1-alkyne-1-yl) biphenyl-2-yl] pyridin-3-carboxamide, (5-bromo-2-methoxy-4-methylpyddin-3-yl) (2, 3, 4-trimethoxy-6-methyl phenyl) - methanone, N-[2-(4-{[3-(4-chlorophenyl) prop-2-alkyne-1-yl] oxy}-3-methoxyphenyl) ethyl]-N2-(methylsulfonyl) valinamide, 4-oxo-4-[(2-phenyl ethyl) amino] butanoic acid, butyl-3-alkyne-1-yl {6-[ ({[ (Z) -(1-methyl-1 H-tetrazol-5-yl) (phenyl) methylidene] amino} oxy) methyl] pyridin-2-yl} carbamate, 4-amino-5-fluoro pyrimidine-2-ol, 3, 4, 5-tris - hydroxybenzoate and oryzastrobin. 12. A composition according to any one of claim 1 to 7, further comprising at least one member selected from fillers, solvents, carriers, emulsifiers, dispersing agents, preventive, a thickening agent and an adjuvant co-agents. 13. Composition according to claim 8, further comprising at least one member selected from fillers, solvents, carriers, emulsifiers, dispersing agents, preventive, a thickening agent and an adjuvant co-agents. 14. A composition according to any one of claim 9 to 11, further comprising at least one member selected from fillers, solvents, carriers, emulsifiers, dispersing agents, preventive, a thickening agent and an adjuvant co-agents. 15. Claim 1 to 14 of any one of the use of a composition for treating seed. 16. A composition according to any one of claim 1 to 14 as fungicides and/or the use of insecticides. 17. Use according to claim 16, is for reducing the insects, acarids, nematodes and/or plant pathogens in plants and plant parts of the overall damage and recovery loss of the fruit or vegetable. 18. Use according to claim 16 or 17, for processing conventional plant or transgenic plants or their seeds. 19. For reducing the insects, acarids, nematodes and/or plant pathogens in plants and plant parts of the overall damage and recovery method of the loss of the fruit or vegetable, method comprising simultaneously or sequentially administering a synergistic effective amount of one biological control agent and at least one fungicide (I), Biological control agent is Bacillus subtilis AQ30002 (NRRL Accession No. B-50421); A fungicide (I) is selected from methane cream spirit, efficient cream spirit (mefenoxam), propamocarb-HCl and fludioxonil; Wherein the biological control agent and a fungicide (I) a synergistic weight ratio in the range of 1:1 to 1:0 .01. 20. Method according to claim 19, further comprising at least one additional fungicide (II), with the proviso that the biological control agent, fungicides (I) and a fungicide (II) are not the same. 21. Included in the spatially separated arrangement of the present synergistically effective amounts of a biological control agent and at least one fungicide (I) of the kit, Biological control agent is Bacillus subtilis AQ30002 (NRRL Accession No. B-50421); A fungicide (I) is selected from methane cream spirit, efficient cream spirit (mefenoxam), propamocarb-HCl and fludioxonil; Wherein the biological control agent and a fungicide (I) a synergistic weight ratio in the range of 1:1 to 1:0 .01.
法律状态
(CN104507319B) LEGAL DETAILS FOR CN104507319  Actual or expected expiration date=2033-05-29    Legal state=ALIVE    Status=GRANTED     Event publication date=2013-05-29  Event code=CN/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=CN CN201380040576  Application date=2013-05-29  Standardized application number=2013CN-80040576     Event publication date=2015-04-08  Event code=CN/A  Event type=Examination events  Published application  Publication country=CN  Publication number=CN104507319  Publication stage Code=A  Publication date=2015-04-08  Standardized publication number=CN104507319     Event publication date=2015-04-08  Event code=CN/C06  Event indicator=Pos  Event type=Examination events  Publication    Event publication date=2015-06-24  Event code=CN/C10  Event type=Examination events  Request of examination as to substance    Event publication date=2018-08-03  Event code=CN/B  Event indicator=Pos  Event type=Event indicating In Force  Granted patent for invention  Publication country=CN  Publication number=CN104507319  Publication stage Code=B  Publication date=2018-08-03  Standardized publication number=CN104507319B
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