Polypodal chelants for metallopharmaceuticals 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2002090342 A1 2002-07-11 [US20020090342]US6776977 B2 2004-08-17 [US6776977] / 2002-07-112004-08-17
申请号/申请日
2001US-10033770 / 2001-12-27
发明人
LIU SHUANG;
申请人
ACP LANTERN ACQUISITION;LANTHEUS MEDICAL IMAGING;
主分类号
IPC分类号
A61K-049/04A61K-049/10A61K-051/04C07F-009/22C07F-009/38C07F-013/00
摘要
(US6776977) Tripodal polyaminophosphonate chelants are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and compositions.  Therapeutic and imaging methods of use are also disclosed.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2001US-10033770 2001-12-27 2001US-60260615 2001-01-09
主权利要求
(US6776977) 1. A tripodal polyaminophosphonate chelant having the formula: wherein R1 is selected from the group consisting of phenyl, benzyl, imidazolyl, pyridyl and thiophenyl, each substituted with 0-2 OH. What is claimed is: 2.  A tripodal polyaminophosphonate chelant according to claim 1, having the formula: 3.  A pharmaceutical composition for treating heavy metal toxicity in a patient in need thereof, comprising a therapeutically effective amount of the tripodal polyaminophosphonate chelant of claim 1 and a pharmaceutically acceptable carrier.
法律状态
(US6776977) LEGAL DETAILS FOR US2002090342  Actual or expected expiration date=2012-09-17    Legal state=DEAD    Status=LAPSED     Event publication date=2001-12-27  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US10033770  Application date=2001-12-27  Standardized application number=2001US-10033770     Event publication date=2001-12-27  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: HARTLEY, MICHAEL G    Event publication date=2001-12-27  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1616     Event publication date=2001-12-27  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=2001-12-27  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2001-12-27  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: N0469.70021US01    Event publication date=2001-12-27  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 23628    Event publication date=2002-04-15  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2001-12-19  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:LIU, SHUANG REEL/FRAME:012824/0241     Event publication date=2002-05-17  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2002-07-11  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2002090342  Publication stage Code=A1  Publication date=2002-07-11  Standardized publication number=US20020090342     Event publication date=2002-11-24  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2003-06-05  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2003-07-10  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2003-07-10  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2003-09-11  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2003-09-16  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2003-12-11  Event code=US/AINEA  Event type=OAI  Event type=Examination events  Informal or Non-Responsive Amendment after Examiner Action    Event publication date=2003-12-11  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2004-02-09  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2004-03-19  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2004-03-31  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2004-04-01  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2004-07-13  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2004-07-29  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=2004-08-17  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US6776977  Publication stage Code=B2  Publication date=2004-08-17  Standardized publication number=US6776977     Event publication date=2004-08-17  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 98  Overlap Delays: 0  Non Overlap Delays: 98   PTO Office Delays: 36  Applicant Delays: 96  Adjustment total:  Number of days of extension=38    Event publication date=2004-10-18  Event code=US/PET  Event type=APL  Petition Entered    Event publication date=2005-03-28  Event code=US/PTEAD  Event type=Administrative notifications  Event type=Extension of term of duration of protection  Adjustment of PTE or PTA Calculation by PTO    Event publication date=2007-08-28  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=3     Event publication date=2008-01-09  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2008-01-08  ASSIGNMENT OF PATENTS ASSIGNOR:BRISTOL-MYERS SQUIBB PHARMA COMPANY REEL/FRAME:020339/0341     Event publication date=2008-01-25  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2008-01-25     Year of payment of annual fees=4     Event publication date=2008-03-06  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2008-01-08  GRANT OF SECURITY INTEREST ASSIGNOR:ACP LANTERN ACQUISITION, INC. REEL/FRAME:020609/0506     Event publication date=2008-03-07  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2008-01-08  MERGER ASSIGNOR:ACP LANTERN ACQUISITION, INC. REEL/FRAME:020609/0733     Event publication date=2008-03-07  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2008-02-14  CHANGE OF NAME ASSIGNOR:BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. REEL/FRAME:020609/0746     Event publication date=2008-08-12  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2010-05-13  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2010-05-10  RELEASE OF PATENT SECURITY AGREEMENT ASSIGNOR:ABLECO FINANCE LLC REEL/FRAME:024380/0363     Event publication date=2010-05-13  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2010-05-10  RELEASE OF PATENT SECURITY AGREEMENT ASSIGNOR:ABLECO FINANCE LLC REEL/FRAME:024380/0363     Event publication date=2011-08-30  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=7     Event publication date=2012-04-02  Event code=US/REMI  Event type=Administrative notifications  Maintenance fee reminder mailed    Event publication date=2012-08-17  Event code=US/LAPS  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapse for failure to pay maintenance fees    Event publication date=2012-08-17  Event code=US/FP  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Expired due to failure to pay maintenance fee  Effective date of the event=2012-08-17     Event publication date=2012-09-17  Event code=US/FP  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Expired due to failure to pay maintenance fee    Event publication date=2012-09-17  Event code=US/EXP  Event indicator=Neg  Event type=Event indicating Not In Force  Patent expired    Event publication date=2015-09-01  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=11
专利类型码
A1B2
国别省市代码
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