CHIMERIC TOXINS COMPRISING GnRH FOR TARGETED THERAPY 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
EP1007095 A2 2000-06-14 [EP1007095]EP1007095 B1 2004-09-15 [EP1007095] / 2000-06-142004-09-15
申请号/申请日
1997EP-0925249 / 1997-06-04
发明人
YARKONI SHAI;NECHUSHTAN AMOTZ;LORBERBOUM-GALSKI HAYA;MARIANOVSKI IRINA;
申请人
YISSUM RESEARCH DEVELOPMENT;
主分类号
IPC分类号
A01N-037/18A61K-031/00A61K-038/00A61K-038/22A61K-038/24A61K-039/395A61K-039/40A61K-039/42A61K-039/44A61K-047/48A61P-035/00C07H-021/02C07H-021/04C07KC07K-001/00C07K-002/00C07K-004/00C07K-005/00C07K-007/00C07K-014/00C07K-014/21C07K-014/
摘要
(EP1007095) The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A.  The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins.  The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine lyomyoma cells, extra uterian endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.00000
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
代理机构
;
优先权号
1996IL-0118570 1996-06-04 1997WO-IL00180 1997-06-04
主权利要求
(EP1007095)  1. Targeted chimeric toxin molecule obtained by fusion and expression of cDNA sequences encoding     at least one cell-targeting moiety comprising a gonadotropin-releasing hormone (GnRH) and adapted to recognize specifically cells bearing GnRH binding sites, and     at least one cell-killing moiety essentially consisting of a mutated form of Pseudomonas Exotoxin for killing specific cells bearing GnRH binding sites.  2. Targeted chimeric toxin molecule as claimed in claim 1, comprising a targeting moiety which recognizes GnRH binding sites of cells selected from the group consisting of malignant adenocarcinoma cells, benign uterine lyomyoma cells, endometrial island cells and pituitary tumor adenoma cells.  3. Targeted chimeric toxin molecule as claimed in claim 1 or 2, obtained by fusion of an oligonucleotide, encoding ten amino acids of a GnRH analog as shown in Figure 1c, to a mutated DNA fragment of the full length Pseudomonas Exotoxin to obtain GnRH-PE66.  4. Targeted chimeric toxin molecule as claimed in claim 1 or 2, obtained by fusion of an oligonucleotide encoding ten amino acids of a GnRH analog as shown in Figure 1c to a DNA fragment comprising domains II and III of the Pseudomonas Exotoxin, to obtain GnRH-PE40.  5. A plasmid comprising a DNA sequence encoding a targeted chimeric toxin as claimed in any preceding claim 1 to 4.   6. A method for the production of targeted chimeric toxin molecules as defined in claim 3, comprising the step of ligating an oligonucleotide encoding ten amino acids of a GnRH analog upstream to a DNA fragment encoding a mutated Pseudomonas exotoxin to obtain GnRH-PE66.  7. A method for the production of targeted chimeric toxin molecules as defined in claim 4, comprising the step of ligating an oligonucleotide encoding ten amino acids of a GnRH analog upstream to a DNA fragment encoding domains II and III of Pseudomonas Exotoxin to obtain GnRH-PE40.  8. Pharmaceutical composition comprising as active substance targeted chimeric toxin molecules as claimed in any preceding claim 1 to 4.  9. Use of targeted chimeric toxin molecules as claimed in any claim 1 to 4 for preparing a medicament for treatment of malignant carcinomas and benign tumors.  10. Use as claimed in any claim 1 to 4 for preparing a medicament for systemic administration or transcervical washing of the endometrial cavity.  11. Use of targeted chimeric toxin molecules as claimed in any claim 1 to 4 for preparing a medicament for treating endometriosis.  12. Use as claimed in claim 10 for preparing a medicament for peritoneal washing or ultrasonic guided or laparoscopic intra-endometrial injection or systemic administration.  13. Use of targeted chimeric toxin molecules as claimed in any claim 1 to 4 for preparing a medicament for treatment of uterine myomas.   14. Use as claimed in claim 13 for preparing a medicament for trans-cervical washing of the endometrial cavity.  15. Use of targeted chimeric toxin molecules as claimed in any claim 1 to 4 for preparing a medicament for treatment of pituitary adenomas.  16. Use as claimed in claim 15 for preparing a medicament for intra-thecal administration.  17. Use of targeted chimeric toxin molecules as claimed in any claim 1 to 4 for preparing a medicament for treatment of Benign Prostatic Hyperplasia (BPH).  18. Use as claimed in any claim 17 for preparing a medicament for systemic or trans-uteral administration.  19. Use of chimeric toxins as claimed in any claim 1 to 4 for preparing a medicament for treatment of polycystic breast disease.  20. Use as claimed in claim 19 for preparing a medicament for systemic administration.
法律状态
(EP1007095) LEGAL DETAILS FOR EP1007095  Actual or expected expiration date=2017-06-04    Legal state=DEAD    Status=EXPIRED     Event publication date=1997-06-04  Event code=EP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=EP EP97925249  Application date=1997-06-04  Standardized application number=1997EP-0925249     Event publication date=2000-06-14  Event code=EP/A2  Event type=Examination events  Application published without search report  Publication country=EP  Publication number=EP1007095  Publication stage Code=A2  Publication date=2000-06-14  Standardized publication number=EP1007095     Event publication date=2000-06-14  Event code=EP/AK  Event indicator=Pos  Event type=Designated states  Designated contracting states: Benannte vertragsstaaten AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE    Event publication date=2000-06-14  Event code=EP/17P  Event indicator=Pos  Event type=Examination events  Request for examination filed Pruefungsantrag gestellt  Effective date of the event=1998-11-30     Event publication date=2000-12-06  Event code=EP/RBV  Event indicator=Pos  Event type=Designated states  Event type=Corrections  Designated contracting states (correction): Benannte vertragsstaaten (korr.) AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE    Event publication date=2001-01-03  Event code=EP/17Q  Event indicator=Pos  Event type=Examination events  First examination report Erster pruefungsbescheid  Effective date of the event=2000-11-15     Event publication date=2003-12-10  Event code=EP/RIC1  Event type=Classification modifications  Event type=Corrections  Classification (correction) IPC: 7A 61P  35/00   B    Event publication date=2003-12-10  Event code=EP/RTI1  Event type=Corrections  Title (correction) CHIMERIC TOXINS COMPRISING GNRH FOR TARGETED THERAPY     Event publication date=2003-12-10  Event code=EP/RIC1  Event type=Classification modifications  Event type=Corrections  Classification (correction) IPC: 7A 61K  47/48   A    Event publication date=2004-09-15  Event code=EP/B1  Event indicator=Pos  Event type=Event indicating In Force  Patent specification  Publication country=EP  Publication number=EP1007095  Publication stage Code=B1  Publication date=2004-09-15  Standardized publication number=EP1007095     Event publication date=2004-09-15  Event code=EP/AK  Event indicator=Pos  Event type=Designated states  Designated contracting states: Benannte vertragsstaaten AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE    Event publication date=2004-12-08  Event code=EP/RAP2  Event type=Change of name or address  Event type=Reassignment  Transfer of rights of an EP granted patent Patentinhaber uebertragung (korr.)    Event publication date=2005-09-07  Event code=EP/26N  Event indicator=Pos  Event type=No opposition filed  Event type=Event indicating In Force  No opposition filed Kein einspruch eingelegt  Effective date of the event=2005-06-16     Event publication date=2017-06-04  Event code=EP/EEDX  Event indicator=Neg  Event type=Event indicating Not In Force  Patent has expired MEMBER STATE LEGAL DETAILS FOR AT275976  Actual or expected expiration date=2006-09-15    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=AT Corresponding appl: AT97925249  Application date in the designated or member state=1997-06-04   Application number in the designated or member state=1997AT-0925249T Corresponding cc:  Designated or member state=AT Corresponding pat: AT275976  Publication stage code in the designated or member state=T  Publication date in the designated or member state=2004-10-15   Publication number in the designated or member state=ATE275976    Event publication date=2005-06-04  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=AT   Effective date of the event=2005-06-04  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR BE  Actual or expected expiration date=2005-06-30    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=BE     Event publication date=2004-09-30  Event code=EP/BECA  Event type=Change of name or address  BE: Change of holder's address BE: Changement d'adresse de titulaire de brevet Corresponding cc:  Designated or member state=BE   Effective date of the event=2004-09-15     Event publication date=2005-06-30  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=BE   Effective date of the event=2005-06-30  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2007-12-31  Event code=EP/BERE  Event indicator=Neg  Event type=Event indicating Not In Force  BE: Lapsed BE: Dechu Corresponding cc:  Designated or member state=BE   Effective date of the event=2005-06-30  MEMBER STATE LEGAL DETAILS FOR CH  Actual or expected expiration date=2010-06-30    Legal state=DEAD    Status=EXPIRED   Corresponding cc:  Designated or member state=CH     Event publication date=2004-09-15  Event code=EP/REG  Event code=CH/EP  Event indicator=Pos  Event type=Entry into national phase  Reference to a national code Entry in the national phase Eintritt in die nationale phase Corresponding cc:  Designated or member state=CH     Event publication date=2005-01-31  Event code=EP/REG  Event code=CH/NV  Event type=Change of name or address  Reference to a national code New agent Neuer vertreter/nouveaux mandataires/nuovi mandatari Corresponding cc:  Designated or member state=CH     Event publication date=2009-12-10  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2009-12-10     Year of payment of annual fees=13  Corresponding cc:  Designated or member state=CH     Event publication date=2010-06-30  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=CH   Effective date of the event=2010-06-30  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2011-01-31  Event code=EP/REG  Event code=CH/PL  Event indicator=Neg  Event type=Event indicating Not In Force  Reference to a national code Patent ceased Loeschung/radiation/radiazion Corresponding cc:  Designated or member state=CH  MEMBER STATE LEGAL DETAILS FOR DE69730747  Actual or expected expiration date=2011-01-01    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE Corresponding appl: DE69730747  Application date in the designated or member state=1997-06-04   Application number in the designated or member state=1997DE-6030747 Corresponding cc:  Designated or member state=DE Corresponding pat: DE69730747  Publication stage code in the designated or member state=D1  Publication date in the designated or member state=2004-10-21   Publication number in the designated or member state=DE69730747    Event publication date=2004-10-21  Event code=EP/REF  Event type=Entry into national phase  Corresponds to: Corresponding cc:  Designated or member state=DE     Event publication date=2009-12-10  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2009-12-10     Year of payment of annual fees=13  Corresponding cc:  Designated or member state=DE     Event publication date=2011-01-01  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=DE   Effective date of the event=2011-01-01  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR DK1007095  Actual or expected expiration date=2005-06-30    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DK Corresponding appl: DK97925249  Application date in the designated or member state=1997-06-04   Application number in the designated or member state=1997DK-0925249 Corresponding cc:  Designated or member state=DK Corresponding pat: DK1007095  Publication stage code in the designated or member state=T3  Publication date in the designated or member state=2005-01-24   Publication number in the designated or member state=DK1007095T    Event publication date=2005-01-24  Event code=EP/REG  Event code=DK/T3  Event indicator=Pos  Event type=Event indicating In Force  Reference to a national code Translation of EP patent Corresponding cc:  Designated or member state=DK     Event publication date=2005-06-30  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=DK   Effective date of the event=2005-06-30  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2006-03-06  Event code=EP/REG  Event code=DK/EBP  Event indicator=Neg  Event type=Event indicating Not In Force  Reference to a national code Patent lapsed Ep patentet bortfaldet Corresponding cc:  Designated or member state=DK  MEMBER STATE LEGAL DETAILS FOR ES2229358  Actual or expected expiration date=2009-06-05    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=ES Corresponding appl: ES97925249  Application date in the designated or member state=1997-06-04   Application number in the designated or member state=1997ES-0925249T Corresponding cc:  Designated or member state=ES Corresponding pat: ES2229358  Publication stage code in the designated or member state=T3  Publication date in the designated or member state=2005-04-16   Publication number in the designated or member state=ES2229358    Event publication date=2005-04-16  Event code=EP/REG  Event code=ES/FG2A  Event indicator=Pos  Event type=Event indicating In Force  Reference to a national code Definitive protection Proteccion definitiva Corresponding cc:  Designated or member state=ES     Event publication date=2008-08-28  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2008-08-28     Year of payment of annual fees=12  Corresponding cc:  Designated or member state=ES     Event publication date=2009-06-05  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=ES   Effective date of the event=2009-06-05  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2010-08-26  Event code=EP/REG  Event code=ES/FD2A  Event indicator=Neg  Event type=Event indicating Not In Force  Reference to a national code Announcement of lapse in spain Ep-patente caducidades Corresponding cc:  Designated or member state=ES   Effective date of the event=2009-06-05  MEMBER STATE LEGAL DETAILS FOR FI  Actual or expected expiration date=2005-06-14    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=FI     Event publication date=2005-06-14  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=FI   Effective date of the event=2005-06-14  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR FR  Actual or expected expiration date=2011-02-28    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=FR     Event publication date=2005-08-19  Event code=EP/ET  Event indicator=Pos  Event type=Event indicating In Force  FR: Translation filed FR: Traduction a ete remise Corresponding cc:  Designated or member state=FR     Event publication date=2009-12-22  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2009-12-22     Year of payment of annual fees=13  Corresponding cc:  Designated or member state=FR     Event publication date=2010-06-30  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=FR   Effective date of the event=2010-06-30  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2011-02-28  Event code=EP/REG  Event code=FR/ST  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Reference to a national code Notification of lapse Constatation de decheances Corresponding cc:  Designated or member state=FR   Effective date of the event=2011-02-28  MEMBER STATE LEGAL DETAILS FOR GB  Actual or expected expiration date=2006-06-04    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=GB     Event publication date=2004-09-15  Event code=EP/REG  Event code=GB/FG4D  Event indicator=Pos  Event type=Event indicating In Force  Reference to a national code European patent granted Corresponding cc:  Designated or member state=GB     Event publication date=2005-06-01  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2005-06-01     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=GB     Event publication date=2006-06-04  Event code=EP/GBPC  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  GB: European patent ceased through non-payment of renewal fee Corresponding cc:  Designated or member state=GB   Effective date of the event=2006-06-04     Event publication date=2006-06-04  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=GB   Effective date of the event=2006-06-04  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR GR  Actual or expected expiration date=2006-01-03    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=GR Corresponding appl: GR20040404108    Event publication date=2005-01-25  Event code=EP/REG  Event code=GR/EP  Event indicator=Pos  Event type=Event indicating In Force  Reference to a national code Ep patent validated in greece Corresponding cc:  Designated or member state=GR     Event publication date=2006-01-03  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=GR   Effective date of the event=2006-01-03  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR IE  Actual or expected expiration date=2009-06-04    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=IE     Event publication date=2004-10-20  Event code=EP/REG  Event code=IE/FG4D  Event indicator=Pos  Event type=Event indicating In Force  Reference to a national code European patents granted designating ireland Corresponding cc:  Designated or member state=IE     Event publication date=2008-08-29  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2008-08-29     Year of payment of annual fees=12  Corresponding cc:  Designated or member state=IE     Event publication date=2009-06-04  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=IE   Effective date of the event=2009-06-04  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2010-03-31  Event code=EP/REG  Event code=IE/MM4A  Event indicator=Neg  Event type=Event indicating Not In Force  Reference to a national code Patent lapsed Corresponding cc:  Designated or member state=IE  MEMBER STATE LEGAL DETAILS FOR IT  Actual or expected expiration date=2009-06-04    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=IT     Event publication date=2008-08-29  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=2008-08-29     Year of payment of annual fees=12  Corresponding cc:  Designated or member state=IT     Event publication date=2009-06-04  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=IT   Effective date of the event=2009-06-04  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR LI  Actual or expected expiration date=2010-06-30    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=LI     Event publication date=2010-06-30  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=LI   Effective date of the event=2010-06-30  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR NL  Actual or expected expiration date=2006-01-01    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=NL     Event publication date=2005-02-01  Event code=EP/NLT2  Event type=Change of name or address  Event type=Reassignment  NL: Modifications (of names), taken from the european patent patent bulletin NL: (naams)wijzigingen, die zijn overgenomen uit het ep octrooiblad Corresponding cc:  Designated or member state=NL     Event publication date=2006-01-01  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=NL   Effective date of the event=2006-01-01  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2006-01-01  Event code=EP/NLV4  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  NL: Lapsed or anulled due to non-payment of the annual fee NL: Vervallen wegens niet betalen van een jaarcijns Corresponding cc:  Designated or member state=NL   Effective date of the event=2006-01-01  MEMBER STATE LEGAL DETAILS FOR PT  Actual or expected expiration date=2006-03-06    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=PT     Event publication date=2005-01-31  Event code=EP/REG  Event code=PT/TE4A  Event type=Change of name or address  Reference to a national code Change of address (patent) Mudanca de residencia (patente) Corresponding cc:  Designated or member state=PT   Effective date of the event=2004-12-07     Event publication date=2005-01-31  Event code=EP/REG  Event code=PT/SC4A  Event indicator=Pos  Event type=Examination events  Reference to a national code Translation is available Corresponding cc:  Designated or member state=PT   Effective date of the event=2004-12-07     Event publication date=2005-06-04  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=PT   Effective date of the event=2005-06-04  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2006-03-06  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=PT   Effective date of the event=2006-03-06  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES  MEMBER STATE LEGAL DETAILS FOR SE  Actual or expected expiration date=2005-06-05    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=SE     Event publication date=2005-01-11  Event code=EP/REG  Event code=SE/TRGR  Event indicator=Pos  Event type=Event indicating In Force  Event type=Entry into national phase  Reference to a national code Translation of granted ep patent Europeiska patent som uppraetthalls i aendrad avfattning Corresponding cc:  Designated or member state=SE     Event publication date=2005-06-05  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=SE   Effective date of the event=2005-06-05  LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES     Event publication date=2006-02-21  Event code=EP/EUG  Event indicator=Neg  Event type=Event indicating Not In Force  SE: European patent has lapsed SE: Europeiskt patent har upphoert att gaella Corresponding cc:  Designated or member state=SE
专利类型码
A2B1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部