Inhibitors of cyclin-dependent kinase 7 (cdk7) 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
CA2972239 A1 2016-06-30 [CA2972239] / 2016-06-30
申请号/申请日
2015CA-2972239 / 2015-12-23
发明人
GRAY NATHANAEL S;LIANG YANKE;ZHANG TINGHU;KWIATKOWSKI NICHOLAS PAUL;
申请人
DANA FARBER CANCER INSTITUTE;
主分类号
IPC分类号
A61K-031/5383A61P-035/00C07D-487/04
摘要
(CA2972239) The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof.  Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.  Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
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地址
代理人
代理机构
;
优先权号
2014US-62096040 2014-12-23 2015WO-US00297 2015-12-23
主权利要求
(CA2972239) 1. A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is -NR a R b, -CHR a R b or -OR a, wherein each of R a and R b is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, op
法律状态
(CA2972239) LEGAL DETAILS FOR CA2972239  Actual or expected expiration date=2035-12-23    Legal state=ALIVE    Status=PENDING     Event publication date=2015-12-23  Event code=CA/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=CA CA2972239  Application date=2015-12-23  Standardized application number=2015CA-2972239     Event publication date=2016-06-30  Event code=CA/A1  Event type=Examination events  Application laid open  Publication country=CA  Publication number=CA2972239  Publication stage Code=A1  Publication date=2016-06-30  Standardized publication number=CA2972239
专利类型码
A1
国别省市代码
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