Biological active coating components, coatings, and coated surfaces 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2004112482 A2 2004-12-29 [WO2004112482]WO2004112482 A8 2005-05-06 [WO2004112482] / 2004-12-292005-05-06
申请号/申请日
2003WO-US28345 / 2003-09-09
发明人
MCDANIEL STEVEN C;
申请人
MCDANIEL STEVEN C;
主分类号
IPC分类号
A01N-063/00A61F-002/00A61K-038/46A61K-038/48A61K-039/00A61K-047/48A62D-101/02A62D-101/45C09D-005/00C09D-007/12C09J-011/02C12M-001/34C12N-009/00C12N-009/14C12N-009/88C12N-009/90C12N-011/08C12S-009/00
摘要
(WO2004112482) Disclosed herein are novel coatings and paints comprising a biomolecule composition, wherein the biomolecule composition comprises a phosphoric triester hydrolase.  Also disclosed herein are methods of detoxification of a surface contaminated with an organophosphorus compound by contacting the surface with such a coating or paint.  Also disclosed herein are novel coating and paint components derived from microorganisms.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2002US-60409102 2002-09-09 2003US-10655345 2003-09-04
主权利要求
(WO2004112482) What is claimed is: 1. A coating comprising a biomolecule composition, wherein the biomolecule composition comprises an active biomolecule. 2. The coating of claim 1 , wherein the active biomolecule comprises a proteinaceous molecule. 3. The coating of claim 2, wherein the proteinaceous molecule binds a ligand, contacts a living organism, or a combination thereof. 4. The coating of claim 3, wherein the proteinaceous molecule binds a ligand. 5. The coating of claim 4, wherein the ligand comprises an antigen, a substrate, an inhibitor, or a combination thereof. 6. The coating of claim 5, wherein the ligand comprises a chemical toxic to humans. 7. The coating of claim 6, wherein the ligand comprises an organophosphorus compound. 8. The coating of claim 2, wherein the proteinaceous molecule comprises a peptide, a polypeptide, a protein, or a combination thereof. 9. The coating of claim 8, wherein the proteinaceous molecule comprises an enzyme, an antibody, a receptor, a transport protein, structural protein, or a combination thereof. 10. The coating of claim 8, wherein the proteinaceous molecule comprises an enzyme. 11. The coating of claim 10, wherein the enzyme comprises an oxidoreductase, a transferase, a hydrolase, a lyase, an isomerase, a ligase, or a combination thereof. 12. The coating of claim 11 , wherein the enzyme comprises a hydrolase. 13. The coating of claim 12, wherein the hydrolase comprises an esterase. 14. The coating of claim 13, wherein the esterase comprises a phosphoric triester hydrolase. 15. The coating of claim 14, wherein the phosphoric triester hydrolase comprises an aryldialkylphosphatase, a diisopropyl-fluorophosphatase, or a combination thereof. 16. The coating of claim 14, wherein the phosphoric triester hydrolase comprises a combination of phosphoric triester hydrolases. 17. The coating of claim 15, wherein the phosphoric triester hydrolase comprises an aryldialkylphosphatase. 18. The coating of claim 15, wherein the aryldialkylphosphatase comprises an organophosphorus hydrolase, a human paraoxonase, an animal carboxylase, or a functional equivalent thereof. 19. The coating of claim 15, wherein the aryldialkylphosphatase comprises an organophosphorus hydrolase or a functional equivalent thereof. 20. The coating of claim 19, wherein the organophosphorus hydrolase comprises an Agrobacterium radiobacter P230 organophosphate hydrolase, a Flavobacterium balustinum parathion hydrolase, a Pseudomonas diminuta phosphotriesterase, a Flavobacterium sp opd gene product, a Flavobacterium sp. parathion hydrolase opd gene product, or a functional equivalent thereof. 21. The coating of claim 20, wherein the organophosphorus hydrolase comprises a functional equivalent of Agrobacterium radiobacter P230 organophosphate hydrolase, a Flavobacterium balustinum parathion hydrolase, a Pseudomonas diminuta phosphotriesterase, a Flavobacterium sp opd gene product, or a Flavobacterium sp. parathion hydrolase opd gene product. 22. The coating of claim 21 , wherein the functional equivalent is a structural analog. 23. The coating of claim 22, wherein the structural analog comprises a Co2+, Fe2+, Cu2+, Mn2+, Cd2+,or Ni2+at the enzyme active site. 24. The coating of claim 21 , wherein the functional equivalent is a sequence analog. 25. The coating of claim 21 , wherein the sequence analog is an alteration in sequence length. 26. The coating of claim 24, wherein the sequence analog lacks a leader peptide sequence. 27. The coating of claim 24, wherein the sequence analog is a fusion protein. 28. The coating of claim 20, wherein the organophosphorus hydrolase comprises a Pseudomonas diminuta phosphotriesterase, or a functional equivalent thereof. 29. The coating of claim 28, wherein the organophosphorus hydrolase comprises a Pseudomonas diminuta phosphotriesterase. 30. The coating of claim 28, wherein the organophosphorus hydrolase comprises a Pseudomonas diminuta phosphotriesterase functional equivalent. 31. The coating of claim 28, wherein the Pseudomonas diminuta phosphotriesterase functional equivalent comprises a sequence analog. 32. The coating of claim 31 , wherein the sequence analog comprises an amino acid substitution. 33. The coating of claim 32, wherein the sequence analog is H55C, H57C, C59A, G60A, S61A, I106A, I106G, W131A, W131 F, W131 K, F132A, F132H, F132Y, L136Y, L140Y, H201C, H230C, H254A, H254R, H254S, H257A, H257L, H257Y, L271A, L271Y, L303A, F306A, F306E, F306H, F306K, F306Y, S308A, S308G, Y309A, M317A, M317H, M317K, M317R, H55C/H57C, H55C/H201C, H55C/H230C, H57C/H201C, H57C/H230C, A80V/S365P, I106A/F132A, I106A/S308A, I106G/F132G, I106G/S308G, F132Y/F306H, F132H/F306H, F132H/F306Y, F132Y/F306Y, F132A/S308A, F132G/S308G, L182S/V310A, H201C/H230C, H254R/H257L, H55C/H57C/H201 C, H55C/H57C/H230C, H55C/H201C/H230C, I106A/F132A/H257Y, I106A/F132A/H257W, I106G/F132G/S308G, L130M/H257Y/I274N, H257Y/I274N/S365P, H55C/H57C/H201 C/H230C, I106G/F132G/H257Y/S308G, or A14T/A80V/L185R/H257Y/I274N. 34. The coating of claim 17, wherein the aryldialkylphosphatase comprises a human paraoxonase or a functional equivalent thereof. 35. The coating of claim 34, wherein the human paraoxonase comprises an HPON1 gene product or a functional equivalent thereof. 36. The coating of claim 35, wherein the human paraoxonase comprises a HPON1 gene product functional equivalent. 37. The coating of claim 28, wherein the HPON1 gene product functional equivalent comprises a sequence analog. 38. The coating of claim 37, wherein the sequence analog comprises an amino acid substitution. 39. The coating of claim 38, wherein the sequence analog is E32A, E48A, E52A, D53A, D88A, D107A, H114N, D121A, H133N, H154N, H160N, W193A, W193F, W201A, W201 F, H242N, H245N, H250N, W253A, W253F, D273A, W280A, W280F, H284N, or H347N. 40. The coating of claim 17, wherein the aryldialkylphosphatase comprises an animal carboxylase. 41. The coating of claim 40, wherein the animal carboxylase comprises an insect carboxylase or a functional equivalent thereof. 42. The coating of claim 41 , wherein the insect carboxylase comprises a Plodia interpundella carboxylase, Chrysomya putoria carboxylase, Lucilia cuprina carboxylase, Musca domestica carboxylase carboxylase, or a functional equivalent thereof. 43. The coating of claim 15, wherein the phosphoric triester hydrolase comprises a diisopropyl-fluorophosphatase. 44. The coating of claim 43, wherein the diisopropyl-fluorophosphatase comprises an organophosphorus acid anhydrolase, a squid-type DFPase, a Mazur-type DFPase, or a functional equivalent thereof. 45. The coating of claim 44, wherein the diisopropyl-fluorophosphatase comprises an organophosphorus acid anhydrolase or a functional equivalent thereof. 46. The coating of claim 45, wherein the organophosphorus acid anhydrolase comprises an Altermonas organophosphorus acid anhydrolase, a prolidase, or a functional equivalent thereof. 47. The coating of claim 46, wherein the organophosphorus acid anhydrolase comprises an Altermonas organophosphorus acid anhydrolase or a functional equivalent thereof. 48. The coating of claim 47, wherein the Altermonas organophosphorus acid anhydrolase comprises an Alteromonas sp JD6.5 organophosphorus acid anhydrolase, an Alteromonas haloplanktis organophosphorus acid anhydrolase, an Altermonas undina organophosphorus acid anhydrolase, or a functional equivalent thereof. 49. The coating of claim 46, wherein the organophosphorus acid anhydrolase comprises a prolidase or a functional equivalent thereof. 50. The coating of claim 49, wherein the prolidase comprises a human prolidase, a Mus musculus prolidase, a Ladobacillus helveticus prolidase, an Escherichia coli prolidase, an Escherichia coli aminopeptidase P, or a functional equivalent thereof. 51. The coating of claim 44, wherein the diisopropyl-fluorophosphatase comprises a squid-type DFPase, or a functional equivalent thereof. 52. The coating of claim 51 , wherein the squid-type DFPase comprises a Loligo vulgaris DFPase, a Loligo pealei DFPase, a Loligo opalescens DFPase, or a functional equivalent thereof. 53. The coating of claim 52, wherein the squid-type DFPase comprises a Loligo vulgaris DFPase, or a functional equivalent thereof. 54. The coating of claim 53, wherein the squid-type DFPase comprises a Loligo vulgaris DFPase, or a functional equivalent thereof. 55. The coating of claim 54, wherein the squid-type DFPase comprises a Loligo vulgaris DFPase functional equivalent. 56. The coating of claim 55, wherein the Loligo vulgaris DFPase functional equivalent comprises a sequence analog. 57. The coating of claim 56, wherein the sequence analog comprises an amino acid substitution. 58. The coating of claim 57, wherein the sequence analog is H181 N, H224N, H274N, H219N, H248N, or H287N. 59. The coating of claim 57, wherein the sequence analog is an alteration in sequence length. 60. The coating of claim 59, wherein the sequence analog is a fusion protein. 61. The coating of claim 44, wherein the diisopropyl-fluorophosphatase comprises a Mazur-type DFPase or a functional equivalent thereof. 62. The coating of claim 61 , wherein the Mazur-type DFPase comprises a mouse liver DFPase, a hog kidney DFPase, a Bacillus stearothermophilus strain OT DFPase, an Escherichia coli DFPase, or a functional equivalent thereof. 63. The coating of claim 1 , wherein the phosphoric triester hydrolase comprises a Plesiomonas sp. strain M6 mpd gene product, a Xanthomonas sp. phosphoric triester hydrolase, a Tetrahymena phosphoric triester hydrolase, or a functional equivalent thereof. 64. The coating of claim 2, wherein the proteinaceous molecule contacts a living organism. 65. The coating of claim 64, wherein the proteinaceous molecule comprises a ligand capable of binding to an active biomolecule of the living organism. 66. The coating of claim 65, wherein the active biomolecule of the living organism comprises a receptor, an enzyme, a transport protein, or a combination thereof. 67. The coating of claim 1 , wherein the biomolecular composition comprises 0.001 % to 40% of the coating composition by weight or volume. 68. The coating of claim 1 , wherein the active biomolecule comprises 0.001 % to 40% of the coating composition by weight or volume. 69. The coating of claim 1 , wherein the biomolecule composition comprises a microorganism based particulate material. 70. The coating of claim 69, wherein the microorganism based particulate material a whole cell material. 71. The coating of claim 70, wherein the microorganism based particulate material a cell fragment microorganism based particulate material. 72. The coating of claim 1 , wherein the coating comprises a buffer. 73. The coating of claim 21 , wherein the buffer comprises a bicarbonate. 74. The coating of claim 1 , wherein the coating is 5 um to 1500 um thick upon the surface. 75. The coating of claim 1 , wherein the coating is 15 um to 500 um thick upon the surface. 76. The coating of claim 1 , wherein the coating comprises a paint. 77. The coating of claim 1 , wherein the coating comprises a clear coating. 78. The coating of claim 77, wherein the clear coating comprises a lacquer, a varnish, a shellac, a stain, a water repellent coating, or a combination thereof. 79. The coating of claim 1 , wherein the coating comprises a multicoat system. 80. The coating of claim 79, wherein the multicoat system comprises 2 to 10 layers. 81. The coating of claim 80, wherein one layer of the multicoat system comprises the biomolecular composition. 82. The coating of claim 80, wherein a plurality of layers of the multicoat system comprise the biomolecular composition. 83. The coating of claim 80, wherein each layer of the multicoat system is coating is 15 um to 150 um thick. 84. The coating of claim 79, wherein the multicoat system comprises a sealer, a water repellent, a primer, an undercoat, or a topcoat. 85. The coating of claim 79, wherein the multicoat system comprises a topcoat. 86. The coating of claim 85, wherein the topcoat comprises the biomolecular composition. 87. The coating of claim 1 , wherein the coating comprises a binder, a liquid component, a colorant, an additive, or a combination thereof. 88. The coating of claim 1 , wherein the coating undergoes film formation. 89. The coating of claim 88, wherein film formation occurs at ambient conditions. 90. The coating of claim 88, wherein film formation occurs at baking conditions. 91. The coating of cla m 90, wherein baking cond itions is between 40°C and 50°C 92. The coating of cla m 90, wherein baking cond tions is between 40°C and 65°C 93. The coating of cla m 90, wherein baking cond itions is between 40°C and 110°C 94. The coating of claim 88, wherein the coating comprises a volatile component and a non-volatile component. 95. The coating of claim 94, wherein the coating undergoes film formation by loss of part of the volatile component. 96. The coating of claim 94, wherein the volatile component comprises a volatile liquid component. 97. The coating of claim 96, wherein the volatile liquid component comprises a solvent, a thinner, a diluent, or a combination thereof. 98. The coating of claim 94, wherein the non-volatile component comprises a binder, a colorant, a plasticizer, a coating additive, or a combination thereof. 99. The coating of claim 88, wherein film formation occurs by crosslinking of a binder. 100. The coating of claim 99, wherein film formation occurs by crosslinking of a plurality of binders. 101. The coating of claim 88, wherein film formation occurs by irradiating the coating. 102. The coating of claim 1 , wherein the coating produces a self-cleaning film. 103. The coating of claim 1 , wherein the coating is a non-film forming coating. 104. The coating of claim 103, wherein the non-film forming coating comprises a non- film formation binder. 105. The coating of claim 103, wherein the non-film forming coating comprises a coating component in a concentration that is insufficient to produce a solid film. 106. The coating of claim 105, wherein the coating component comprises a binder that contributes to thermoplastic film formation. 107. The coating of claim 105 wherein the coating component contributes to thermosetting film formation. 108. The coating of claim 107, wherein the coating component comprises a binder, catalyst, initiator, or combination thereof. 109. The coating of claim 105, wherein the coating component has a concentration of 0%. 110. The coating of claim 110, wherein the coating produces a temporary film. 111. The coating of claim 110, wherein the temporary film has a poor resistance to a coating remover. 112. The coating of claim 110, wherein the temporary film has a poor scrub resistance, a poor solvent resistance, a poor water resistance, a poor weathering property, a poor adhesion property, or a combination thereof. 113. The coating of claim 1 , wherein the coating comprises an architectural coating, an industrial coating, a specification coating, or a combination thereof. 114. The coating of claim 1 , wherein the coating comprises an architectural coating. 115. The coating of claim 114, wherein the architectural coating comprises a wood coating, a masonry coating, an artist's coating, or a combination thereof. 116. The coating of claim 114, wherein the architectural coating has a pot life of at least 12 months at ambient conditions. 117. The coating of claim 114, wherein the architectural coating undergoes film formation at ambient conditions. 118. The coating of claim 1 , wherein the coating comprises an industrial coating. 119. The coating of claim 118, wherein the industrial coating comprises an automotive coating, a can coating, sealant coating, a marine coating, or a combination thereof. 120. The coating of claim 119, wherein the industrial coating undergoes film formation at baking conditions. 121. The coating of claim 1 , wherein the coating comprises a specification coating. 122. The coating of claim 121 , wherein the specification coating comprises a pipeline coating, traffic marker coating, aircraft coating, a nuclear power plant coating, or a combination thereof. 123. The coating of claim 1 , wherein the coating comprises a water-borne coating. 124. The coating of claim 123, wherein the water-borne coating is a latex coating. 125. The coating of claim 123, wherein the water-borne coating has a density of 1.20 kg/L to 1.50 kg/L. 126. The coating of claim 1 , wherein the coating comprises a solvent-borne coating. 127. The coating of claim 126, wherein the solvent-borne coating has a density of 0.90 kg/L to 1.2 kg/L. 128. The coating of claim 1 , wherein the coating has a viscosity during application of 72 Ku to 95 Ku. 129. The coating of claim 1 , wherein the coating has a viscosity prior to application of 100 P to 1000 P. 130. The coating of claim 1 , wherein the coating has a viscosity during application of 0.5 P to 2.5 P. 131. The coating of claim 1 , wherein the coating has a viscosity of 100 P to 1000 P upon a surface immediately after application. 132. The coating of claim 1 , wherein the coating comprises a binder. 133. The coating of claim 132, wherein the binder comprises a thermoplastic binder, a thermosetting binder, or a combination thereof. 134. The coating of claim 133, wherein the coating comprises a thermoplastic binder. 135. The coating of claim 134, wherein the coating produces a film by thermoplastic film formation. 136. The coating of claim 133, wherein the coating comprises a thermosetting binder. 137. The coating of claim 136, wherein the coating produces a film by thermosetting film formation. 138. The coating of claim 132, wherein the binder comprises an oil-based binder. 139. The coating of claim 138, wherein the oil-based binder comprises an oil, an alkyd, an oleoresinous binder, a fatty acid epoxide ester, or a combination thereof. 140. The coating of claim 139, wherein the coating produces a layer 15 um to 25 μm thick upon the vertical surface or 15 um to 40 μm thick upon the horizontal surface. 141. The coating of claim 132, wherein the binder comprises an oil. 142. The coating of claim 132, wherein the binder comprises an alkyd. 143. The coating of claim 132, wherein the binder comprises an oleoresinous binder. 144. The coating of claim 132, wherein the binder comprises a fatty acid epoxide ester. 145. The coating of claim 132, wherein the binder comprises a polyester resin. 146. The coating of claim 145, wherein the polyester resin comprises a hydroxy- terminated polyester. 147. The coating of claim 145, wherein the polyester resin comprises a carboxylic acid-lerminaled polyester. 148. The coating of claim 145, wherein the coating comprises a urethane, an amino resin, or a combination thereof. 149. The coating of claim 132, wherein the binder comprises a modified cellulose. 150. The coating of claim 149, wherein the modified cellulose comprises a cellulose ester. 151. The coating of claim 149, wherein the modified cellulose comprises a nitrocellulose. 152. The coating of claim 149, wherein the coating comprises an amino binder, an acrylic binder, urethane binder, or a combination thereof. 153. The coating of claim 132, wherein the binder comprises a polyamide. 154. The coating of claim 153, wherein the coating comprises an epoxide. 155. The coating of claim 132, wherein the binder comprises an amino resin. 156. The coating of claim 155, wherein the coating comprises an acrylic binder, an alkyd resin, a polyester binder, or a combination thereof. 157. The coating of claim 132, wherein the binder comprises an urethane binder. 158. The coating of claim 157, wherein the coating comprises a polyol, an amine, an epoxide, a silicone, a vinyl, a phenolic, a triacrylate, or a combination thereof. 159. The coating of claim 132, wherein the binder comprises a phenolic resin. 160. The coating of claim 159, wherein the coating comprises an alkyd resin, an amino resin, a blown oil, an epoxy resin, a polyamide, a polyvinyl resin, or a combination thereof. 161. The coating of claim 132, wherein the binder comprises an epoxy resin. 162. The coating of claim 161 , wherein the coating comprises an amino resin a phenolic resin, a polyamide, a ketimine, an aliphatic amine, or a combination thereof. 163. The coating of claim 161 , wherein the epoxy resin comprises a cycloaliphatic epoxy binder. 164. The coating of claim 163, wherein the coating comprises a polyol. 165. The coating of claim 132, wherein the binder comprises a polyhydroxyether binder. 166. The coating of claim 165, wherein the coating comprises an epoxide, a polyurethane comprising an isocyanate moiety, an amino resin, or a combination thereof. 167. The coaling of claim 132, wherein the binder comprises an acrylic resin. 168. The coating of claim 167, wherein the coating comprises an epoxide, a polyurethane comprising an isocyanate moiety, an amino resin, or a combination thereof. 169. The coating of claim 132, wherein the binder comprises a polyvinyl binder 170. The coating of claim 169, wherein the coating comprises an alkyd, an urethane, an amino-resin, or a combination thereof. 171. The coating of claim 132, wherein the binder comprises a rubber resin. 172. The coating of claim 171 , wherein the rubber resin comprises a chlorinated rubber resin, a synthetic rubber resin, or a combination thereof. 173. The coating of claim 171 , wherein the coating comprises an acrylic resin, an alkyd resin, a bituminous resin, or a combination thereof. 174. The coating of claim 132, wherein the binder comprises a bituminous binder. 175. The coating of claim 174, wherein the coating comprises an epoxy resin. 176. The coating of claim 132, wherein the binder comprises a polysulfide binder. 177. The coating of claim 176, wherein the coating comprises a peroxide, a binder comprising an isocyanate moiety, or a combination thereof. 178. The coating of claim 132, wherein the binder comprises a silicone binder. 179. The coating of claim 178, wherein the coating comprises an organic binder. 180. The coating of claim 1 , wherein the coating comprises a liquid component. 181. The coating of claim 180, wherein the liquid component comprises a solvent, a thinner, a diluent, a plasticizer, or a combination thereof. 182. The coating of claim 180, wherein the liquid component comprises a liquid organic compound, an inorganic compound, water, or a combination thereof. 183. The coating of claim 180, wherein the liquid component comprises a liquid organic compound. 184. The coating of claim 183, wherein the liquid organic compound comprises a hydrocarbon, an oxygenated compound, a chlorinated hydrocarbon, a nitrated hydrocarbon, a miscellaneous organic liquid component, a plasticizer, or a combination thereof. 185. The coating of claim 184, wherein the liquid organic compound comprises a hydrocarbon. 186. The coating of claim 185, wherein the hydrocarbon comprises an aliphatic hydrocarbon, a cycloaliphatic hydrocarbon, a terpene, an aromatic hydrocarbon, or a combination thereof. 187. The coating of claim 186, wherein the hydrocarbon comprises an aliphatic hydrocarbon. 188. The coating of claim 187, wherein the aliphatic hydrocarbon comprises a petroleum ether, pentane, hexane, heptane, isododecane, a kerosene, a mineral spirit, a VMP naphthas, or a combination thereof. 189. The coating of claim 186, wherein the hydrocarbon comprises a cycloaliphatic hydrocarbon. 190. The coating of claim 189, wherein the cycloaliphatic hydrocarbon comprises cyclohexane, methylcyclohexane, ethylcyclohexane, tetrahydronaphthalene, decahydronaphthalene, or a combination thereof. 191. The coating of claim 186, wherein the hydrocarbon comprises a terpene. 192. The coating of claim 191 , wherein the terpene comprises wood terpentine oil, pine oil, α-pinene, β-pinene, dipentene, D-limonene, or a combination thereof. 193. The coating of claim 186, wherein the hydrocarbon comprises an aromatic hydrocarbon. 194. The coating of claim 193, wherein the aromatic hydrocarbon comprises benzene, toluene, ethylbenzene, xylene, cumene, a type I high flash aromatic naphthas, a type II high flash aromatic naphthas, mesitylene, pseudocumene, cymol, styrene, or a combination thereof. 195. The coating of claim 184, wherein the liquid organic compound comprises an oxigenated compound. 196. The coating of claim 195, wherein the oxigenated compound comprises an alcohol, an ester, a glycol ether, a ketone, an ether, or a combination thereof. 197. The coating of claim 196, wherein the oxigenated compound comprises an alcohol. 198. The coating of claim 197, wherein the alcohol comprises methanol, ethanol, propanol, isopropanol, 1 -butanol, isobutanol, 2-butanol, fe -butanol, amyl alcohol, isoamyl alcohol, hexanol, methylisobutylcarbinol, 2-ethylbutanol, isooctyl alcohol, 2- elhylhexanol, isodecanol, cylcohexanol, methylcyclohexanol, trimethylcyclohexanol, benzyl alcohol, methylbenzyl alcohol, furfuryl alcohol, tetrahydrofurfuryl alcohol, diacetone alcohol, trimethylcyclohexanol, or a combination thereof. 199. The coating of claim 196, wherein the oxigenated compound comprises an ester. 200. The coating of claim 199, wherein the ester comprises methyl formate, ethyl formate, butyl formate, isobutyl formate, methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, sec-butyl acetate, amyl acetate, isoamyl acetate, hexyl acetate, cyclohexyl acetate, benzyl acetate, methyl glycol acetate, ethyl glycol acetate, butyl glycol acetate, ethyl diglycol acetate, butyl diglycol acetate, 1 -methoxypropyl acetate, ethoxypropyl acetate, 3-methoxybulyl acetate, ethyl 3-ethoxypropionate, isobutyl isobutyrate, ethyl lactate, butyl lactate, butyl glycolate, dimethyl adipate, glutarate, succinate, ethylene carbonate, propylene carbonate, butyrolactone, or a combination thereof. 201. The coating of claim 196, wherein the oxigenated compound comprises a glycol ether. 202. The coating of claim 201 , wherein the glycol ether comprises methyl glycol, ethyl glycol, propyl glycol, isopropyl glycol, butyl glycol, methyl diglycol, ethyl diglycol, butyl diglycol, ethyl triglycol, butyl triglycol, diethylene glycol dimethyl ether, methoxypropanol, isobutoxypropanol, isobutyl glycol, propylene glycol monoethyl ether, 1-isopropoxy-2-propanol, propylene glycol mono-n-propyl ether, propylene glycol n-butyl ether, methyl dipropylene glycol, methoxybutanol, or a combination thereof. 203. The coating of claim 196, wherein the oxigenated compound comprises a ketone. 204. The coating of claim 203, wherein the ketone comprises acetone, methyl ethyl ketone, methyl propyl ketone, methyl isopropyl ketone, methyl butyl ketone, methyl isobutyl ketone, methyl amyl ketone, methyl isoamyl ketone, diethyl ketone, ethyl amyl ketone, dipropyl ketone, diisopropyl ketone, cyclohexanone, methylcylcohexanone, trimethylcyclohexanone, mesityl oxide, diisobutyl ketone, isophorone, or a combination thereof. 205. The coating of claim 196, wherein the oxigenated compound comprises an ether. 206. The coating of claim 205, wherein the ether comprises diethyl ether, diisopropyl ether, dibutyl ether, di-sec-butyl ether, methyl tert-butyl ether, tetrahydrofuran, 1 ,4- dioxane, metadioxane, or a combination thereof. 207. The coating of claim 184, wherein the liquid organic compound comprises a chlorinated hydrocarbon. 208. The coating of claim 207, wherein the chlorinated hydrocarbon comprises methylene chloride, trichloromethane, tetrachloromethane, ethyl chloride, isopropyl chloride, 1 ,2-dichloroethane, 1 ,1 ,1-trichloroethane, trichloroethylene, 1 ,1 ,2,2- tetrachlorethane, 1 ,2-dichloroethylene, perchloroethylene, 1 ,2-dichloropropane, chlorobenzene, or a combination thereof. 209. The coating of claim 184, wherein the liquid organic compound comprises a nitrated hydrocarbon. 210. The coating of claim 209, wherein the nitrated hydrocarbon comprises a nitroparaffin, N-methyl-2-pyrrolidone, or a combination thereof. 211. The coating of claim 184, wherein the liquid organic compound comprises a miscellaneous organic liquid. 212. The coating of claim 209, wherein the miscellaneous organic liquid comprises carbon dioxide; acetic acid, methylal, dimethylacetal, A/,Λ/-dimethylformamide, N,N- dimethylacetamide, dimethylsulfoxide, tetramethylene suflone, carbon disulfide, 2- nitropropane, Λ/-methylpyrrolidone, hexamethylphosphoric triamide, 1 ,3-dimethyl-2- imidazolidinone, or a combination thereof. 213. The coating of claim 184, wherein the liquid organic compound comprises a plasticizer. 214. The coating of claim 213, wherein the plasticizer comprises an adipate, an azelate, a citrate, a chlorinated plasticizer, an epoxide, a phosphate, a sebacate, a phthalate, a polyester, a trimellitate, or a combination thereof. 215. The coating of claim 180, wherein the liquid component comprises an inorganic compound. 216. The coating of claim 215, wherein the inorganic compound comprises ammonia, hydrogen cyanide, hydrogen fluoride, hydrogen cyanide, sulfur dioxide, or a combination thereof. 217. The coating of claim 180, wherein the liquid component comprises water. 218. The coating of claim 217, wherein the liquid component further comprises methanol, ethanol, propanol, isopropyl alcohol, terf-butanol, ethylene glycol, methyl glycol, ethyl glycol, propyl glycol, butyl glycol, ethyl diglycol, methoxypropanol, methyldipropylene glycol, dioxane, tetrahydorfuran, acetone, diacetone alcohol, dimethylformamide, dimethyl sulfoxide, ethylbenzene, tetrachloroethylene, p-xylene, toluene, diisobutyl ketone, tricholorethylene, trimethylcyclohexanol, cyclohexyl acetate, dibutyl ether, trimethylcyclohexanone, 1 ,1 ,1-tricholoroethane, hexane, hexanol, isobutyl acetate, butyl acetate, isophorone, nitropropane, butyl glycol acetate, 2-nitropropane, methylene chloride, methyl isobutyl ketone, cyclohexanone, isopropyl acetate, methylbenzyl alcohol, cyclohexanol, nitroethane, methyl ter(...)
法律状态
(WO2004112482) LEGAL DETAILS FOR WO2004112482  Actual or expected expiration date=2007-03-04    Legal state=DEAD    Status=LAPSED     Event publication date=2003-09-09  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOUS0328345  Application date=2003-09-09  Standardized application number=2003WO-US28345     Event publication date=2004-12-29  Event code=WO/A2  Event type=Examination events  International application published without international search report  Publication country=WO  Publication number=WO2004112482  Publication stage Code=A2  Publication date=2004-12-29  Standardized publication number=WO2004112482     Event publication date=2004-12-29  Event code=WO/AL  Event indicator=Pos  Event type=Designated states  Designated countries for regional patents GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG    Event publication date=2004-12-29  Event code=WO/AK  Event indicator=Pos  Event type=Designated states  Designated states AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW    Event publication date=2005-05-06  Event code=WO/A8  Event indicator=Pos  Event type=Examination events  Modified first page  Publication country=WO  Publication number=WO2004112482  Publication stage Code=A8  Publication date=2005-05-06  Standardized publication number=WO2004112482     Event publication date=2005-05-06  Event code=WO/D17  Event type=Administrative notifications  Declaration under article 17(2)a    Event publication date=2007-03-04  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. 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