(US20190116797) STRUCTURE, SYNTHESIS, AND APPLICATIONS FOR POLY(PHENYLENE ETHYNYLENES) (PPEs) 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(US20190116797) STRUCTURE, SYNTHESIS, AND APPLICATIONS FOR POLY(PHENYLENE ETHYNYLENES) (PPEs)
公开号/公开日
US20190116797 / 2019-04-25
申请号/申请日
US16/192,248 / 2018-11-15
发明人
WHITTEN DAVID GSCHANZE KIRK SPARTHASARATHY ANANDJI EUNKYUNGOGAWA MOTOKATSUCORBITT THOMAS SDASCIER DIMITRIWANG YINGISTA LINNEA KHILL ERIC H;
申请人
STC UNIVERSITY OF NEW MEXICO UNIVERSITY OF FLORIDA;
主分类号
IPC分类号
A01N-025/08 A01N-025/10 A01N-033/10 A01N-033/12 A01N-041/04 A01N-043/10 A01N-043/90 C07C-217/14 C07C-217/20 C07C-309/11 C07C-309/24 C07D-333/16 C07D-409/14 C07D-487/08 C08G-061/02 C08G-061/12 C08G-075/00
摘要
(US20190116797) The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2010US-61366850 2010US-61399483 2010US-61400122 2010US-61401825 2010US-61401832 2010US-61404236 2010US-61413878 2010US-61456552 2011US-61471800 2011US-61499097 2011WO-US43922 2013US-13809572 2016US-15348756 2018US-16192248
主权利要求
(US20190116797) 1. A material comprising a poly(phenylene ethynylene), the poly(phenylene ethynylene) having the structure: wherein   the poly(phenylene ethynylene) is grafted to the material by chemisorption or wherein the poly(phenylene ethynylene) is attached to the material by physisorption;   n is selected from the group consisting of whole numbers between 5 and 200;   A is C2C6H2;   B is selected from the group consisting of C2C6H2 and C2C4H2S;   C=is either C6H4 or not present;   X is selected from the group consisting of: H, [C2C6H4]2COOCH2CH3, and [C2C4H2S][C2C6H4]COOCH2CH3;   Y is selected from the group consisting of H and COOCH2CH3;   ZA is selected from the group consisting of O(CH2)k(C6H12N2)C6H132+, O(CH2)kSO2−, O(CH2)kN(CH2CH3)3+, and O(CH2)kN(CH3)3+, wherein k is selected from the group consisting of the whole number between 1 and 10;   ZB is selected from the group consisting of H and (OCH2CH2)3OCH3;   if ZA is O(CH2)k(C6H12N2)C6H132+, then ZB is H, A=C2C6H2, C, if present, is C6H4, and X is selected from the group consisting of H and [C2C6H4]2COOCH2CH3;   if Y is H, then X is H or not H;   if X is H, then Y is H or not H and C is not present;   if X is [C2C6H4]COOCH2CH3, then Y is COOCH2CH3 and C is C6H4;   if ZA is O(CH2)kSO3−, then ZB is H, A=C2C6H2, C is not present, and one or both of X and Y is H;   if ZA is O(CH2)kN(CH2CH3)3+, then ZB is (OCH2CH2)3OCH3, A=C2C6H2, C is not present, and one or both of X and Y is H;   if ZA is O(CH2)kN(CH3)3+, and ZB is (OCH2CH2)3OCH3, then C is not present, A=C2C6H2 and one or both of X and Y is H;   if ZA is O(CH2)kN(CH3)3+, ZB is H, and C is not present, then A=C2C4H2S and one or both of X and Y is H; and   if ZA is O(CH2)kN(CH3)3+, ZB is H, and C is present, then Y═COOCH2CH3 and X is selected from the group consisting of [C2C6H4]2COOCH2CH3 and [C2C4H2S][C2C6H4]COOCH2CH3, and    if X is [C2C6H4]2COOCH2CH3, then B=C2C6H2, and    if X is [C2C4H2S][C2C6H4]COOCH2CH3, then B=C2C4H2S;   wherein the material further comprises a stimuli responsive material (SRM) that has an active form and an inactive form, wherein the SRM changes between the active and inactive form in response to a stimuli comprising temperature, pressure, pH, or a combination thereof, wherein when the SRM is in the active form the poly(phenylene ethynylene) attracts a biological species, and when the SRM is in the inactive form the poly(phenylene ethynylene) releases or does not attract the biological species. 2. The material of claim 1, wherein the biological species comprises a protein, cell, bacteria, virus, or combination thereof. 3. The material of claim 1, wherein, when the SRM is in an active form, the poly(phenylene ethynylene) exhibits at least one of biocidal activity, antiviral activity, antibacterial activity, and antifungal activity. 4. The material of claim 1, wherein the material comprises a film comprising the poly(phenylene ethynylene) and the SRM. 5. The material of claim 4, wherein when the SRM is in the inactive form the film contracts and becomes hydrophobic thereby attracting the biological species, and when the SRM is in the active form the film expands and releases or does not attract the biological species. 6. The material of claim 4, wherein the film is a self-cleaning reusable film. 7. The material of claim 4, wherein changing the SRM from the inactive form to the active form releases biological species from the film thereby self-cleaning the film and preparing the film for reuse. 8. The material of claim 1, wherein antimicrobial activity of the poly(phenylene ethynylene) is masked when the SRM is in the inactive form, and the poly(phenylene ethynylene) has antimicrobial activity when the SRM is in the active form. 9. The material of claim 1, wherein the SRM changes between the active and inactive form in response to temperature. 10. The material of claim 9, wherein below a lower critical solution temperature (LCST) the material releases or does not attract the biological species, wherein above the LCST the material attracts the biological species. 11. The material of claim 10, wherein a film comprises the poly(phenylene ethynylene) and the SRM, wherein below the LCST the SRM is in an expanded form and shields the poly(phenylene ethynylene) from attraction to the biological species, and above the LCST the SRM is in a contracted form that exposes the poly(phenylene ethynylene) to attraction to the biological species. 12. The material of claim 10, wherein antimicrobial activity of the poly(phenylene ethynylene) is masked below the LCST of the stimuli responsive material, and the poly(phenylene ethynylene) has antimicrobial activity above the LCST of the stimuli responsive material. 13. The material of claim 1, wherein the SRM comprises poly(N-isopropyl-acrylamide), an oligo-ethylene glycol oligomer terminated with a thiol, or a combination thereof. 14. The material of claim 1, wherein A and B=C2C6H2, C is not present, one or both of X and Y is H, ZB═H, and ZA═O(CH2)k(C6H12N2)C6H132+. 15. The material of claim 1, wherein A and B=C2C6H2, C is not present, one or both of X and Y is H, and:   ZB═H, and ZA═O(CH2)kSO3−; or   ZA═O(CH2)kN(CH3)3+, ZB═(OCH2CH2)3OCH3; or   ZA═O(CH2)kN(CH3)3+, ZB═(OCH2CH2)3OCH3, and k=6. 16. The material of claim 1, wherein A and B=C2C6H2, C is not present, one or both of X and Y is H, ZA═O(CH2)kN(CH3)3+, ZB═(OCH2CH2)3OCH3, and k=6. 17. The material of claim 1, wherein A and B=C2C6H2, C is not present, one or both of X and Y is H, ZA═O(CH2)kN(CH3)3+, and ZB═(OCH2CH2)2OCH3. 18. The material of claim 1, wherein A=C2C6H2, B=C2C4H2S, C is not present, one or both of X and Y is H, ZA═O(CH2)kN(CH3)3+, and ZB═H. 19. The material of claim 1, wherein A and B=C2C6H2, C=C6H4, X═[C2C61H4]2COOCH2CH3, Y═COOCH2CH3, ZB═H, and:   B=C2C6H2, and ZA═O(CH2)kN(CH3)3+; or   B=C2C6H2, and ZA═O(CH2)k(C6H12N2)C6H132+; or   B=C2C4H2S, and ZA═O(CH2)kN(CH3)3+. 20. The material of claim 1, wherein k=3.
法律状态
PENDING
专利类型码
A1
国别省市代码
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