Structural carotenoid analogue for inhibition and amelioration of disease 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP5187700) 病気​の​抑制​と​改善​の​ため​の​構造​上​の​カロチノイド​類似​体
公开号/公开日
JP2010248243 A 2010-11-04 [JP2010248243]JP5187700 B2 2013-04-24 [JP5187700] / 2010-11-042013-04-24
申请号/申请日
2010JP-0170929 / 2010-07-29
发明人
LOCKWOOD SAMUEL FOURNIER;O'MALLEY SEAN;WATUMULL DAVID G;HIX LAURA M;JACKSON HENRY;NADOLSKI GEOFF;
申请人
CARDAX PHARMACEUTICALS;
主分类号
IPC分类号
A01N-027/00A61K-031/01A61K-031/015A61K-031/045A61K-031/07A61K-031/075A61K-031/12A61K-031/13A61K-031/185A61K-031/215A61K-031/225A61K-031/255A61K-031/325A61K-031/401A61K-031/404A61K-031/4172A61K-031/535A61K-031/537A61K-031/5377A61K-031/66A61K-031/6615A61K-031/665A61K-031/70A61K-031/7024A61K-031/704A61K-031/715A61P-001/00A61P-001/04A61P-001/08A61P-001/16A61P-001/18A61P-003/00A61P-003/02A61P-003/10A61P-007/02A61P-007/04A61P-007/06A61P-009/00A61P-009/04A61P-009/06A61P-009/10A61P-011/00A61P-011/02A61P-011/06A61P-013/02A61P-013/08A61P-013/12A61P-015/08A61P-017/00A61P-017/04A61P-017/06A61P-017/16A61P-019/02A61P-019/08A61P-021/00A61P-025/00A61P-025/16A61P-025/28A61P-025/32A61P-027/12A61P-027/16A61P-031/04A61P-031/12A61P-033/00A61P-033/02A61P-033/06A61P-035/00A61P-035/04A61P-037/04A61P-037/06A61P-037/08A61P-039/02A61P-039/06A61P-041/00A61P-043/00C07C-403/24C07D-207/16C07D-233/60C07D-265/30C07D-307/58C07F-009/02C07F-009/117C07H-013/04
摘要
(JP5187700) PROBLEM TO BE SOLVED: To provide synthesis and use of a structural carotenoid analogue for inhibition and amelioration of a disease.  SOLUTION: A pharmaceutical composition contains a compound having a structure of the formula and one or more carriers allowed of being formulated.  Wherein, each of Ys is independently O or H<sub>2</sub>, each of Rs is independently -alkylene-NR<sup>2</sup><sub>3</sub><sup>+</sup>, -alkylene-NR<sup>2</sup><sub>2</sub>, -alkylene-CO<sub>2</sub>, -CH(NH<sub>2</sub>)CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>NH<sub>2</sub>, or -CH(NH<sub>3</sub>)<sup>+</sup>CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>NH<sub>3</sub><sup>+</sup>, and each of R<sup>2</sup>s is independently H, alkyl or aryl.  COPYRIGHT: (C)2011,JPO&amp;INPIT
机翻摘要
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地址
代理人
代理机构
;
优先权号
2002US-60399194 2002-07-29 2003US-60467973 2003-05-05 2003US-60472831 2003-05-22 2003US-60473741 2003-05-28 2003US-60485304 2003-07-03
主权利要求
(JP5187700) 1. And a compound having the structure of the formula a pharmaceutically acceptable formulation of one or more pharmaceutical composition comprising a carrier and:  wherein, independently or each O Y H2 and, independently of each R - alkylene - NR23+ 、-alkylene - NR22 、-alkylene - CO2- 、-CH(NH2) CH2 CH2 CH2 CH2 NH2 、or - CH (NH3)+ CH2 CH2 CH2 CH2 NH3+ and, each R2 H is independently, alkyl or aryl.  2. R is, - CH (NH2) CH2 CH2 CH2 CH2 NH2 ;or - CH (NH3)+ CH2 CH2 CH2 CH2 NH3+ in a pharmaceutical composition according to claim 1.  3. R is - alkylene - CO2- in a pharmaceutical composition according to claim 1.  4. R is - alkylene - NR23+ in a pharmaceutical composition according to claim 1.  5. For the treatment of ischemia reperfusion injury of the pharmaceutical composition of any one of the claims 1-4.  6. For the treatment of a cancerous or precancerous cells and cancer cells of the pharmaceutical composition of any one of the claims 1-4.  7. For the treatment of liver disease of a pharmaceutical composition according to any one of claims 1-4.
法律状态
(JP5187700) LEGAL DETAILS FOR JP2010248243  Actual or expected expiration date=2023-07-29    Legal state=ALIVE    Status=GRANTED     Event publication date=2010-07-29  Event code=JP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=JP JP2010170929  Application date=2010-07-29  Standardized application number=2010JP-0170929     Event publication date=2010-08-27  Event code=JP/A621  Event indicator=Pos  Event type=Examination events  Written request for application examination  Effective date of the event=2010-08-26  JAPANESE INTERMEDIATE CODE: A621     Event publication date=2010-11-04  Event code=JP/A  Event indicator=Pos  Event type=Examination events  Published application  Publication country=JP  Publication number=JP2010248243  Publication stage Code=A  Publication date=2010-11-04  Standardized publication number=JP2010248243     Event publication date=2011-06-30  Event code=JP/A521  Event type=Restitution or restoration  Written amendment  Effective date of the event=2011-06-29  JAPANESE INTERMEDIATE CODE: A523     Event publication date=2012-12-06  Event code=JP/TRDD  Event indicator=Pos  Event type=Administrative notifications  Trial decision date    Event publication date=2012-12-18  Event code=JP/A01  Event indicator=Pos  Event type=Event indicating In Force  Written decision to grant a patent or to grant a registration (utility model)  Effective date of the event=2012-12-18  JAPANESE INTERMEDIATE CODE: A01     Event publication date=2013-01-24  Event code=JP/A61  Event indicator=Pos  Event type=Event indicating In Force  First payment of annual fees (during grant procedure)  Effective date of the event=2013-01-15  JAPANESE INTERMEDIATE CODE: A61     Event publication date=2013-02-01  Event code=JP/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Renewal fee payment   Annual fees payment date=2013-02-01     Year of payment of annual fees=3  PAYMENT UNTIL: 20160201     Event publication date=2013-02-01  Event code=JP/R150  Event indicator=Pos  Event type=Event indicating In Force   Certificate of patent (=grant) or registration of utility model JAPANESE INTERMEDIATE CODE: R150     Event publication date=2013-04-24  Event code=JP/B2  Event indicator=Pos  Event type=Event indicating In Force  Published granted patent (Second level)  from 01-03-1996 onwards (Published examined patent application (Second level) 1971-1996)  Publication country=JP  Publication number=JP5187700  Publication stage Code=B2  Publication date=2013-04-24  Standardized publication number=JP5187700     Event publication date=2013-10-24  Event code=JP/S111  Event type=Change of name or address  Event type=Reassignment  Request for change of ownership or part of ownership JAPANESE INTERMEDIATE CODE: R313113     Event publication date=2013-10-24  Event code=JP/S531  Event type=Change of name or address  Written request for registration of change of domicile JAPANESE INTERMEDIATE CODE: R313531     Event publication date=2013-11-01  Event code=JP/R350  Event type=Change of name or address  Event type=Reassignment  Written notification of registration of transfer JAPANESE INTERMEDIATE CODE: R350     Event publication date=2016-08-23  Event code=JP/R250  Event indicator=Pos  Event type=Payment or non-payment notifications  Receipt of annual fees JAPANESE INTERMEDIATE CODE: R250     Event publication date=2017-08-22  Event code=JP/R250  Event indicator=Pos  Event type=Payment or non-payment notifications  Receipt of annual fees JAPANESE INTERMEDIATE CODE: R250
专利类型码
AB2
国别省市代码
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