(US10632111) Donepezil derivative and use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(US10632111) Donepezil derivative and use thereof
公开号/公开日
US10632111US20180250278 / 2020-04-282018-09-06
申请号/申请日
US15/972,500 / 2018-05-07
发明人
Liu FeiZhang CuixiaLin ChenggangZhou ChunyanChen PanWang WeiWang Lulu;
申请人
NANJING NORATECH PHARMACEUTICALS;
主分类号
IPC分类号
摘要
(US10632111) The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as disclosed herein; and a method for preparation thereof; and a composition comprising an effective amount of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to use of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof in preparing a medicament for treating a disease resulted from an abnormality in acetylcholinesterase activity.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(US10632111) Birch, Stewart, Kolasch & Birch, LLP
代理机构
;
优先权号
2014CN-0777222 2015US-15533865 2015WO-CN95647 2018US-15972500
主权利要求
(US10632111) What is claimed is: 1. A compound of formula (I):  or a pharmaceutically acceptable salt thereof, wherein R is C6 alkyl group. 2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R is n-hexane. 3. A method of treating dementia in a patient, comprising:   administering to said patient a compound according to claim 1 or the pharmaceutically acceptable salt thereof. 4. A pharmaceutical composition, comprising a compound according to claim 1 or the pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 5. The pharmaceutical composition of claim 4, wherein the excipient is selected from one or more of castor oil, soybean oil, sesame oil, arachis oil, corn oil, cottonseed oil, or glycerides. 6. The pharmaceutical composition of claim 4, further comprising a hydrotropic agent, wherein the hydrotropic agent is selected from one or more of benzyl benzoate or alcohols. 7. The pharmaceutical composition according to claim 4, further comprising a pain relief agent, wherein the pain relief agent is benzyl alcohol. 8. The pharmaceutical composition of claim 5, wherein the excipient is castor oil. 9. The pharmaceutical composition of claim 6, wherein the hydrotropic agent is benzyl benzoate. 10. A method of treating dementia in a patient, comprising:   administering to said patient a pharmaceutical composition comprising a compound according to claim 1 or the pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient. 11. The method of claim 10, wherein the excipient comprises castor oil. 12. The method of claim 10, wherein the pharmaceutical composition further comprises a hydrotropic agent, wherein the hydrotropic agent is benzyl benzoate. 13. The method of claim 3, further comprising administering to said patient a pain relief agent, wherein the pain relief agent is benzyl alcohol. 14. The method of claim 10, further comprising administering to said patient a pain relief agent, wherein the pain relief agent is benzyl alcohol.
法律状态
GRANTED
专利类型码
B2A1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部