New derivatives of [pirimidiniloxi]-e piridimidinilamino- etilfenil-dioxolano. 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(BRPI9509877) Novos derivados de pirimidinilóxi-e piridimidinilamino- etilfenil-dioxolano.
公开号/公开日
BR9509877 A 1997-09-30 [BR9509877]BRPI9509877 A1 1997-09-30 [BRPI9509877] / 1997-09-301997-09-30
申请号/申请日
1995BR-0009877 / 1995-12-06
发明人
LAMBERTH CLEMENS;SCHAUB FRITZ;
申请人
NOVARTIS;
主分类号
IPC分类号
A01N-043/54C07C-069/78C07D-317/16C07D-317/20C07D-317/22C07D-317/24C07D-317/28C07D-405/12C07D-495/04
摘要
(BRPI9509877) The invention discloses 2-[4-(2-(pyrimidin-4-yloxy- and -4-ylamino)-ethyl-phenyl]-dioxolanes of formula (I) wherein R1 is hydrogen, C1-4alkyl, C1-4haloalkyl or C3-6cycloalkyl, R2 is hydrogen, C1-10alkyl, C1-8alkoxy-C1-4alkyl, C3-8alkenyloxy-C1-4alkyl, C3-8haloalkenyloxy-C1-4alkyl, C3-8alkynyloxy-C1-4alkyl, C1-8haloalkoxy-C1-4alkyl, C1-8alkylthio-C1-4alkyl, aryl, aryloxy-C1-4alkyl, aryl-C1-4alkoxy-C1-4-alkyl, heteroaryloxy-C1-4alkyl, C1-4alkoxy-C1-4alkoxy-C1-4alkyl or aryl-C1-8alkyl, R3 and R4 independently are halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxy-C1-4alkyl, C1-4alkoxycarbonyl-C1-4alkyl, C1-4alkoxycarbonyl, cyano-C1-4alkyl, cyano, or -COOH, or R3 and R4 together form a bridge member selected from 1,4-butylene, 1,4-butadienylene, or -S-CH=CH-, each optionally substituted by one or two radicals selected from halogen or C1-4alkyl, and Z is NH or oxygen; the use of such compounds for the control of undesired acarinae, fungi, and insects, compositions for facilitating such use, and the preparation of the compounds of formula I.  (From WO9617843 A2)
机翻摘要
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地址
代理人
代理机构
;
优先权号
1994GB-0024676 1994-12-07 1995WO-EP04795 1995-12-06
主权利要求
(BR9509877)  CLAIMS 1. 2- (4- (2- (pirimidin-4-iloxi- or -4-ilamino) etil one) - fenill-dioxolano of 2 formula I R 3 Ri R R 4 CH-CH Z -? -1/4 (1 1 N=i (1) where It laughs is hydrogen, C1-Cg alquila, C1-C4 haloalquila or C3-C6 cicloalquila, R2 is hydrogen, C1-C10 alquila, C1-C8 alcoxi - C1 - C4 alquila, C3-C8 alqueniloxi-C1-Cg alquila.  C3 - C8 haloalqueniloxi-Ci-Cg alquila, C3 - C8 alquiniloxi-C1-C4 alquila, C1-C8 haloalcoxi-C1-Cg alquila, CI-C8 alquiltio-Ci-Cg alquila, arila, arilexi-C1-C4 alquila, aril-C1-C4 alcoxi - C1-C4 alquila, heteroariloxi-C1-C4 alquila, C1-C4 alcoxi- C1-C4 alcogi-Ci-Cg alquila, or aril-C1-C8 alquila, R3 and Rg independently are halogenio, C1-C4 alquila, C1-C4 alcaxi, C1-C4 alcoxi-C1-C4 alquila, C1 - C4 alcoxicarbonil-C1-C4 alquila, C1-C4 alcoxicarbonila, cyan-C1-C4 alquila, cyan, or - COOH, or together R3 and Rg form a member have to poir.  K) elpefflp0de the g of. 1. , 4-butileho, 1,4-butadienileno, or - S-CH=CHcada optionally substituted by one or two radical selected of halogenio or C1-C4 alquila, and Z is NH or oxygen. 2. Composition in accordance with claim 1, where together R3 and R4 form a bridge of butadienileno or 1,4-butileno optionally substituted, thus together with the ring of on pirimidina which they are for= mam a portion of quinazolina or tetrahidroquinazolina optionally substituted. 3. Composition in accordance with any one of claims 1 or 2, where It laughs is hydrogen or metila. 4. Composition in accordance with any the one of the claims 1 3, where R2 is C1-C8 alquila, C1-C8 alcoxi-C1-Cg alquila, C3-C8 alqueniloxi-C1-C4 alquila, or C1- C4 alcoxi-C1-C4 alcoxi-Ci-Cg alquila. 5. Selected Compostb deo group that [4- consists of 4. aliloximetil-2-metil-2- (2- (quinazolin-4iloxi) - etil one) - fenil] - dioxolano, 4. aliloximetil-2-metil-2 [4- (2- (5,6,7,8-tetrahi- 4 - aliloximetil-2-metil-2 [4- (2- (5,6,7,8-tetrahidroquinazolin-4-iloxi) - etil one) - fenil] - dioxolano, and til) - fen11] - dioxolano and 4. butil-2-metil-2- (4- (2- (5-metil-tieno [2,3, - d]  pirimidin-4-ilamino) - etil) - feni1] - dioxolano. 6. Process for the preparation of a dea composition  .6. *O e. formula I in accordance with reivindietcadeirCeeEMMIS'neend each reaction of wn 2- [4- (2-hidroxietil) - fenil] - dioxolano dea formula II CH 2 - CH 2 - OH (II) or one 2- [4- (2-aminottil) - feni1] - dioxolano dea formula X R2 CH 2 - 2 CH2 NH (x) where Ri and R2 are as defined for formula I NT claim 1, with a dea 4-halopirimidina 3 formula III R R4 HW N NJ where R3 and R4 are as defined for formula I in the claim, and Hal is halogenio, of preference chlorine or bromine. 7. Agricultural composition that understands a dea composition in accordance with formula I agriculturally acceptable claim 1 and one diluente. 8. Method of combat of acarinae and insects understanding the application to acarinae and the insects or its habitat a acaricidamente or insecticidally efficient amount of one compostoda f4rinulas: Ue! aEbrEciii: ctim claim 1. 9. Method of combat of pathogenic fungos with preendendo the application to the fungos or its habitat a fungicidally efficient amount of a dea composition formula I in accordance with claim 1. 10. 2- [4- (2-hidroxietil) - fenil] dioxolano dea formula II C H 2 - 2 CH -0 H (II) where R1 and R2 are as defined for formula I in claim 1. 11. Process for the preparation of one 2- [4- (2hidroxietil) - feni1] - dioxolano dea formula II in accordance with claim 10 that it understands the hidrolisacao of a dea composition formula IV CH - CH 2 -0 ( 1. V) where Ri and R2 as is defined for formula I in claim 1 and X is hydrogen, C1-C4 alquila, 2 C1 - C4 alcoxi, cyan halo, nitro or, and Y is hydrogen, C1-C4 alquila, C1 - C4 alcoxi, cyan halo or, in the presence of an acid one or a base. 12. Dea composition formula t `f R 2 (IV) CH2 CH 2 where Ri and R2 are as defined for formula I in re ivindicacao 1 and X is hydrogen, C1 - C4 alquila, C1-C4 alcoxi, cyan halo, nitro or, and Y is hydrogen, C1-C4 alquila, C1 - C4 alcoxi; cyan halo or. 13. Procesao for the preparation of a dea composition formula IV in accordance with claim 12, that it understands the acetalisacao of a dea composition formula V (v) where Laughs, X and Y is as defined for formula IV in claim 12 with dea a glycol 2 formula VI R rOH (VI) OH where R2 is as defined for formula I in demands cao 1. 14. Made up of formula V CH 2 - 2 CH the (v) en.9 Gen we n n where It laughs, X and Y are as definaoL ba g re'; N: tekhailzW: Ig na claim 5. 15. Dea composition formula X R 2 CH 2 - CH 2 2 NH (x) where Ri and R2 are as defined for formula I in claim 1. 17. Process for the preapracao of a dea composition formula X in accordance with the 16, that it understands hidrolisa- cao of a dea composition formula XI eia (XI) icH2 - N where Ri and Ry Olo as defined for formula I. 18. Dea composition formula XI R 2 (XI) CHFCH 2 where R1 and Ry are as defined for formula I in re= 19 ivindicacao 1 . Process for the preparation of a dea composition formula XI in accordance with claim 18, that it understands the reaction of a dea composition formula II CH2 CH2 OH (II) where Ri and R2 are as defined for formula I in re- ftalimida ivindicacao 1 with. 20. Dea composed formula XI 012. 012 (XI) Hal where Ri and Ry are as defined for formula I in red& t fl ai ivindicacao 1 and Hal is halogenio, bromine. 21. Process for the preparation of a dea composition formula XI in accordance with claim 20, that it understands acetalisacao of a dea composition formula XIII CH2-CH2-Hal 0 where R1 and Hal are as defined for formula XI in claim 20 with dea a glycol formula VI R = I-- OH (VI) OH en and the Clear SUMMARY of Invencad: "NEW DERIVATIVES OF PIRIMIDINILOXI- AND PIRIDIMIDINILAMIND-ETILFENIL-DIOXOLANO". The invention presents 2- [4- (2- (pirimidin-4-iloxi- 5. and -4-ilamino) - etil one) - feniii-dioxolanos of 3 formula I R 2 R4 R FirCHrZ r `N "n where It laughs is hydrogen, C1-C4 alquila, C1-C4 haloalquila or C3-C6 cicloalquila, R2 is hydrogen, C1-C10 alquila, C1 - C8 alcoxi - C1 - C4 alquila, C3 - C8 alqueniloxi-C1-C4 alquila, C3 - C8 haloalquenfloxi-Ci-C4 alquila, C3-C8 alquiniloxi-C1-C4 alquila, C1-C8 haloalcoxi - C1 - C4 alquila, C1-C8 alquiltio-C1-C4 alquila, arila, ariloxi-C1-C4 alquila, aril-C1-C4 alcoxi - C1-C4 alquila, heteroariloxi-C1-C4 alquila, C1 - C4 alcoxi- C1-C4 alcoxi - C1 - C4 alquila, or aril-C1-C8 alquila, R3 and R4 independently are halogenio, C1 - C4 alquila, C1-C4 alcoxi, Ci - C4 alcoxi-C1-C4 alquila, C1-C4 ..... -. e. alcoxicarbonil-C1-C4 alqiiilai and 1/29-; 541,51/21siicarbci nila, cyan-C1 - C4 alquila, cyan, or - COOH, or together R3 and R4 form a member in 1,4-butileno bridge selected, 1,4-butadienileno, or - S-CH=CHcada optionally substituted by one or two radical selected of halogenio or C1-C4 alquila, and - Z is NH or oxygen, the use of such composites for the control of acarinae, fungos and insects not desired, the compositions to facilitate such use, and the preparation of composites dea formula I.  Machine Translated
法律状态
(BRPI9509877) LEGAL DETAILS FOR BR9509877  Actual or expected expiration date=2002-12-10    Legal state=DEAD    Status=REVOKED     Event publication date=1995-12-06  Event code=BR/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=BR BR9509877  Application date=1995-12-06  Standardized application number=1995BR-0009877     Event publication date=1997-09-30  Event code=BR/A1  Event indicator=Pos  Event type=Examination events  Published application  Publication country=BR  Publication number=BRPI9509877  Publication stage Code=A1  Publication date=1997-09-30  Standardized publication number=BRPI9509877     Event publication date=1997-09-30  Event code=BR/A  Event type=Examination events  Published application  Publication country=BR  Publication number=BR9509877  Publication stage Code=A  Publication date=1997-09-30  Standardized publication number=BR9509877     Event publication date=2002-05-07  Event code=BR/FB34  Event indicator=Neg  Event type=Administrative notifications  Technical and formal requirements: requirement - article 34 of industrial property law Exigencias tecnicas e formais: exigencia - art. 34 da lpi    Event publication date=2002-12-10  Event code=BR/FA14  Event indicator=Neg  Event type=Event indicating Not In Force  Dismissal: dismissal - article 34 of industrial property law Arquivamento: arquivamento - art. 34 da lpi
专利类型码
AA1
国别省市代码
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