Substituted 1-azolyl-butan-2-ones, their preparation and their application as fungicides as well as intermediates 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
EP0054865 A1 1982-06-30 [EP--54865]EP0054865 B1 1986-02-26 [EP--54865] / 1982-06-301986-02-26
申请号/申请日
1981EP-0110365 / 1981-12-11
发明人
KRAMER, WOLFGANG, DR.;BUCHEL, KARL HEINZ, PROF.DR.;ELBE, HANS-LUDWIG, DR.;KRAATZ, UDO, DR.;REGEL, ERIK, ING.;FROHBERGER, PAUL-ERNST, DR.;BRANDES, WILHELM, DR.;
申请人
BAYER;
主分类号
IPC分类号
A01N-043/50A01N-043/64A01N-043/653A01N-047/02C07C-045/63C07C-045/67C07C-045/71C07C-049/16C07D-233/60C07D-249/08C07D-521/00
摘要
(EP--54865) 1.  Substituted 1-azolyl-butan-2-ones of the formula see diagramm : EP0054865,P68,F1 in which Az represents 1,2,4-triazol-1-yl and 4-yl or imidazol-1-yl ; R**1 represents hydrogen, alkyl with 1 to 12 and alkenyl and alkinyl with in each case 2 to 12 carbon atoms, and represents optionally C1 -C4 -alkyl-substituted cycloalkyl with 3 to 7 carbon atoms or cycloalkylalkyl with 3 to 7 carbon atoms in the cycloalkyl part and 1 to 4 carbon atoms in the alkyl part, and represents optionally substituted phenoxyalkyl with 1 to 4 carbon atoms in the alkyl part or optionally substituted phenylalkyl with 1 to 4 carbon atoms in the alkyl part, the phenyl substituents to be mentioned in each case being : halogen ; alkyl, alkoxy and alkylthio with in each case 1 to 6 carbon atoms ; cyclohexyl ; dialkylamino with in each case 1 to 4 carbon atoms in each alkyl part ; halogenoalkyl, halogenoalkoxy and halogenoalkylthio with in each case 1 to 4 carbon atoms and 1 to 5 identical or different halogen atoms ; nitro ; cyano ; alkoxycarbonyl with 1 to 4 carbon atoms in the alkyl part ; and optionally halogensubstituted phenyl and phenoxy ; and the grouping -CO-NR**6 R**7 ; n represents the numbers 0 or 1, R**2 represents cyano or the groupings -X-R**3 and -CO-NR**4 R**5 , and, in the case where n does not represent 0 at the same time as R**1 represents hydrogen and Az represents 1,2,4-triazolyl, also additionally represents optionally substituted aryl with 6 to 10 carbon atoms, possible substituents being the aryl substituents already mentioned under R**1 , and represents alkoxycarbonyl with 1 to 4 carbon atoms in the alkyl part ; X represents oxygen, sulphur, or the SO or SO2 group, R**3 represents alkyl with 1 to 6 carbon atoms, halogenoalkyl with 1 to 4 carbon atoms and 1 to 5 identical or different halogen atoms, and represents optionally substituted aryl with 6 to 10 carbon atoms and aralkyl with 6 to 10 carbon atoms in the aryl part and 1 to 2 carbon atoms in the alkyl part, possible substituents being the aryl substituents already mentioned under R**1 ; R**4 represents hydrogen, alkyl with 1 to 4 carbon atoms or optionally substituted aryl with 1 to 10 carbon atoms, possible substituents being the aryl substituents already mentioned under R**1 ; R**5 represents hydrogen or alkyl with 1 to 4 carbon atoms ; and R**6 and R**7 represent hydrogen, alkyl with 1 to 4 carbon atoms, phenyl which is optionally substituted by halogen and alkyl with 1 to 4 carbon atoms, or both together with the adjacent nitrogen atom represent a saturated 5- or 6-membered ring system which can contain nitrogen or oxygen as additional hetero atoms ; and plant-tolerated acid addition salts and metal salt complexes thereof.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
代理机构
;
优先权号
1980DE-3048266 1980-12-20
主权利要求
(EP--54865)  1. 1-Azolyl-butan-2-one of the Formula Substituted Patent Claims 1) EMI90.1 in which Az for 1,2,4-Triazol-1-yl and -4-yl or Imidazol-1-yl stands, R for Hydrogen, Alkyl, Alkenyl, Alkinyl, GE gebenenfalls substituted Cycloalkyl, gegebe nenfalls substituted Cycloalkylalkyl, given if substituted Phenoxyalkyl or gegebe nenfalls substituted Aralkyl stands, for n for the Numbers of 0 or 1, R2 stands for Cyano or the Groupings - X-R3 and 45 - CO-NR R stands, as well as if nicht for the Number of 0, G 1 for Water material and Az stand for n at the same time for the 1,2,4-Triazolyl-Rest, still additionally for substituted if necessary Aryl or Alkoxycarbonyl stands, for X for Oxygen, Sulfur, the THEN or S02 Group stands, for R3 if necessary for Alkyl, Halogen Alkyl, if necessary substituted Aryl or sub stituiertes Aralkyl stands, R if necessary for Hydrogen, Alkyl or substituted Aryl stands and R5 for Hydrogen or Alkyl stands, as well as for their plant-compatible Acid Addition Salts and metal salt complexes. 2. Substituted 1-Azolyl-butan-2-one of the Formula (I) in claim 1, in which G 1 for geradkettiges or branched Alkyl with 1 to 6 Carbon Atoms, Alkenyl and Alkinyl with in each case 2 to 6 Carbon Atoms, given if with Methyl replaced Cyclohexyl and Cyclohexyl Methyl, as well as for Phenoxyalkyl and if necessary substituted Phenylalkyl with in each case 1 to 2, substituted if necessary Stands for Carbon Atoms in the Alkyl Part, whereby as Phenyl substituents are mentioned: Fluorine, Chlorine, Methyl, Ethyl, Isopropyl, tert. - Butyl, Dimethyl amino, Methoxy, Methylthio, Cyclohexyl, Tri Fluorine methyl, Triflumoethoxy, Trifluormethylthio, Nitro, Cyano, as well as if necessary by Fluorine and Chlorine substituiertes Phenyl and Phenoxy, as well as rt) o1ino'i- Phenylaminocarbonyl, Chlorphenylaminocarbonyl and Dibutyl aminocarbonyl group;   R2 for Cyano;  the Groupings - X-R3 and -CO-NR4R5 stands;  as well as if not equivalent timely n for the Number of O, G 1 for Hydrogen and Az for 1,2,4-Triazol stand, still for given if substituted Phenyl stand, whereby as Substituents the Phenyl substituent in question, already mentioned with G 1, come and finally for Methoxycarbonyl, Ethoxycarbonyl and Isopropoxy carbonyl stand;   R3 fur.geradkettiges or branched Alkyl also 1 bis 4 Carbon Atoms or substituted Phenyl and Benzyle stands if necessary, whereby as Substituents to the respective Phenyl remains the Phenyl already with G 1 mentioned substituents are applicable, R4 for Hydrogen, Methyl, Ethyl, Isopropyl or substituted Phenyl stands if necessary, whereby as Substituents Halogen and Alkyl with 1 to 4 Carbon Atoms are applicable;   R5 for Hydrogen, Methyl, Ethyl or Isopropyl stands;  and Az, X and the Index n in the claim 1 the angebene Meaning have. 3. Procedure for the Production of substituted 1-Azolyl butan-2-onen of the Formula EMI92.1 in which Az for 1,2,4-Triazol-1-yl and -4-yl or Imidazol-1 stands yl, G 1 stands if necessary for n for the Numbers of 0 or 1 for Hydrogen, Alkyl, Alkenyl, Alkinyl, if necessary substituted Cycloalkyl, GE gebenenfalls substituted Cycloalkylalkyl, GE gebenenfalls substituted Phenoxyalkyl or substituted Aralkyl, R2 stands for Cyano or the Groupings - X-R3 and -CO-NR4R5 stands, as well as if n for the Number of 0, G 1 for Water material and Az stand not at the same time for the 1,2,4-Triazolyl-Rest, still additionally for Aryl or Alkoxycarbonyl substituted if necessary stands, whereby X for Oxygen, Sulfur, the THEN or S02-Gruppe stands, for R3 if necessary for Alkyl, Halogen Alkyl, if necessary substituted Aryl or sub stituiertes Aralkyl stands, for R4 if necessary for Hydrogen, Alkyl or substituted Aryl stands and for R5 for Hydrogen or Alkyl stands, by the fact characterized that one a) Halogenketone of the Formula EMI93.1 in which Hal for Halogen, in particular Chlorine or Bromine stands and for R2 and n the Meaning indicated above has, whereby however in the Grouping - X-R3 the Substituent X only for Oxygen or Sulfur stands, with Azolen of the Formula H - Az (III) into which Az the Meaning indicated above has, in Presence of a Diluent and in Presence of an Acid Bonding Agent converts;  and if necessary b) in such a way received Connections of the Formula EMI94.1 in which Az, n and R2 the Meaning indicated above have, with an Alkylating Agent of the Formula G 1 Z (IV) into which G 1 the Meaning indicated above has and Z stands for an electron-attractive of Outlet grouping, in Presence of a Base and in Presence of an organic Diluent, or in an aqueous-organic Two-phase system in Presence of a Phase Transfer Catalyst, converts;  and if necessary c) in the Procedures the (A) and (B) received Connections of the Formula EMI95.1 in which, Az, G 1, n and R3 the Meaning indicated above oxidized, after well-known Methods in usual Way, and to in such a way received Connections of the Formula (I) if necessary afterwards still another Acid or a Metal Salt added. 4. Fungicides Means, characterized by one Content of at least a substituted 1-Azolyl butan-2-on of the Formula I in claims 1 and 3. 5. Procedure for the Fight against Mushrooms, thus gekenn draws that one substituted 1 - Azolyl-butan-2-one of the Formula I in claims 1 and 3 on Mushrooms or or their Habitat to influence leaves. 6. Use of 1-Azolyl-butan-2-onen of the Formula I in claims 1 and 3 for the Fight against Mushrooms. 7. Procedure for the Production of fungicides Means, by the fact characterized that one substituted 1-Azolyl-butan-2-one of the Formula I in claims 1 and 3 with Stretching Means and/or surfaces active Means mixes.
法律状态
(EP--54865) LEGAL DETAILS FOR EP0054865  Actual or expected expiration date=2001-12-11    Legal state=DEAD    Status=EXPIRED     Event publication date=1981-12-11  Event code=EP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=EP EP81110365  Application date=1981-12-11  Standardized application number=1981EP-0110365     Event publication date=1982-06-30  Event code=EP/A1  Event type=Examination events  Application published with search report  Publication country=EP  Publication number=EP0054865  Publication stage Code=A1  Publication date=1982-06-30  Standardized publication number=EP--54865     Event publication date=1982-06-30  Event code=EP/AK  Event indicator=Pos  Event type=Designated states  Designated contracting states: Benannte vertragsstaaten AT BE CH DE FR GB IT NL SE    Event publication date=1982-06-30  Event code=EP/17P  Event indicator=Pos  Event type=Examination events  Request for examination filed Pruefungsantrag gestellt  Effective date of the event=1981-12-11     Event publication date=1986-02-26  Event code=EP/B1  Event indicator=Pos  Event type=Event indicating In Force  Patent specification  Publication country=EP  Publication number=EP0054865  Publication stage Code=B1  Publication date=1986-02-26  Standardized publication number=EP--54865     Event publication date=1986-02-26  Event code=EP/AK  Event indicator=Pos  Event type=Designated states  Designated contracting states: Benannte vertragsstaaten AT BE CH DE FR GB IT LI NL SE    Event publication date=1987-02-25  Event code=EP/26N  Event indicator=Pos  Event type=No opposition filed  Event type=Event indicating In Force  No opposition filed Kein einspruch eingelegt    Event publication date=2001-12-11  Event code=EP/EEDX  Event indicator=Neg  Event type=Event indicating Not In Force  Patent has expired MEMBER STATE LEGAL DETAILS FOR AT18213  Actual or expected expiration date=1989-12-11    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=AT Corresponding appl: AT81110365  Application date in the designated or member state=1981-12-11   Application number in the designated or member state=1981AT-0110365T Corresponding cc:  Designated or member state=AT Corresponding pat: AT18213  Publication stage code in the designated or member state=T  Publication date in the designated or member state=1986-03-15   Publication number in the designated or member state=ATE018213    Event publication date=1986-02-26  Event code=EP/REF  Event type=Entry into national phase  Corresponds to: Corresponding cc:  Designated or member state=AT     Event publication date=1986-12-02  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1986-12-02     Year of payment of annual fees=6  Corresponding cc:  Designated or member state=AT     Event publication date=1989-12-11  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=AT   Effective date of the event=1989-12-11  MEMBER STATE LEGAL DETAILS FOR BE  Actual or expected expiration date=1990-12-31    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=BE     Event publication date=1989-12-20  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-12-20     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=BE     Event publication date=1990-12-31  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=BE   Effective date of the event=1990-12-31     Event publication date=1991-06-30  Event code=EP/BERE  Event indicator=Neg  Event type=Event indicating Not In Force  BE: Lapsed BE: Dechu Corresponding cc:  Designated or member state=BE   Effective date of the event=1990-12-31  MEMBER STATE LEGAL DETAILS FOR CH  Actual or expected expiration date=1990-12-31    Legal state=DEAD    Status=EXPIRED   Corresponding cc:  Designated or member state=CH     Event publication date=1989-11-24  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-11-24     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=CH     Event publication date=1990-12-31  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=CH   Effective date of the event=1990-12-31     Event publication date=1991-08-30  Event code=EP/REG  Event code=CH/PL  Event indicator=Neg  Event type=Event indicating Not In Force  Reference to a national code Patent ceased Loeschung/radiation/radiazion Corresponding cc:  Designated or member state=CH  MEMBER STATE LEGAL DETAILS FOR DE  Actual or expected expiration date=1991-09-03    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE Corresponding appl: DE3173926    Event publication date=1986-04-03  Event code=EP/REF  Event type=Entry into national phase  Corresponds to: Corresponding cc:  Designated or member state=DE     Event publication date=1989-11-18  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-11-18     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=DE     Event publication date=1991-09-03  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=DE   Effective date of the event=1991-09-03  MEMBER STATE LEGAL DETAILS FOR FR  Actual or expected expiration date=1991-08-30    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=FR     Event publication date=1986-03-28  Event code=EP/ET  Event indicator=Pos  Event type=Event indicating In Force  FR: Translation filed FR: Traduction a ete remise Corresponding cc:  Designated or member state=FR     Event publication date=1989-11-29  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-11-29     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=FR     Event publication date=1991-08-30  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=FR   Effective date of the event=1991-08-30     Event publication date=1991-10-25  Event code=EP/REG  Event code=FR/ST  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Reference to a national code Notification of lapse Constatation de decheances Corresponding cc:  Designated or member state=FR  MEMBER STATE LEGAL DETAILS FOR GB  Actual or expected expiration date=1990-12-11    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=GB     Event publication date=1989-12-31  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-12-31     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=GB     Event publication date=1990-12-11  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=GB   Effective date of the event=1990-12-11     Event publication date=1991-08-07  Event code=EP/GBPC  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  GB: European patent ceased through non-payment of renewal fee Corresponding cc:  Designated or member state=GB  MEMBER STATE LEGAL DETAILS FOR IT  Actual or expected expiration date=2001-12-11    Legal state=DEAD    Status=EXPIRED   Corresponding cc:  Designated or member state=IT     Event publication date=1986-03-13  Event code=EP/ITF  Event indicator=Pos  Event type=Examination events  IT: Translation for a EP patent filed IT: Deposito traduzione di brevetto europeo Corresponding cc:  Designated or member state=IT     Event publication date=1989-12-31  Event code=EP/ITTA  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  IT: Last paid annual fee IT: Tassa annuale ultimo pagamento Corresponding cc:  Designated or member state=IT  MEMBER STATE LEGAL DETAILS FOR LI  Actual or expected expiration date=1990-12-31    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=LI     Event publication date=1990-12-31  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=LI   Effective date of the event=1990-12-31  MEMBER STATE LEGAL DETAILS FOR NL  Actual or expected expiration date=1991-07-01    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=NL     Event publication date=1989-12-31  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-12-31     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=NL     Event publication date=1991-07-01  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=NL   Effective date of the event=1991-07-01     Event publication date=1991-08-16  Event code=EP/NLV4  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  NL: Lapsed or anulled due to non-payment of the annual fee NL: Vervallen wegens niet betalen van een jaarcijns Corresponding cc:  Designated or member state=NL  MEMBER STATE LEGAL DETAILS FOR SE  Actual or expected expiration date=1990-08-29    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=SE Corresponding appl: SE81110365.4    Event publication date=1989-12-31  Event code=EP/PGFP  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Postgrant: annual fees paid to national office   Annual fees payment date=1989-12-31     Year of payment of annual fees=9  Corresponding cc:  Designated or member state=SE     Event publication date=1990-12-12  Event code=EP/PG25  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapsed in a contracting state announced via postgrant inform. from nat. office to EPO Corresponding cc:  Designated or member state=SE   Effective date of the event=1990-12-12     Event publication date=1995-01-31  Event code=EP/EUG  Event indicator=Neg  Event type=Event indicating Not In Force  SE: European patent has lapsed SE: Europeiskt patent har upphoert att gaella Corresponding cc:  Designated or member state=SE   Effective date of the event=1990-08-29
专利类型码
A1B1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部