Novel fungal isolates, fusacandins 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US5585251 A 1996-12-17 [US5585251] / 1996-12-17
申请号/申请日
1995US-08370934 / 1995-01-10
发明人
ALDER LISA A;BURRES NEAL S;HOCHLOWSKI JILL E;JACKSON MARIANNA;MCALPINE JAMES B;
申请人
ABBOTT LABORATORIES;
主分类号
IPC分类号
A01N-043/16C07H-015/10
摘要
(US5585251) Novel antifungal agents having the formula: <IMAGE> wherein R is hydrogen or a radical of the formula <IMAGE> and pharmaceutically acceptable prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
机翻摘要
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地址
代理人
代理机构
;
优先权号
1995US-08370934 1995-01-10
主权利要求
(US5585251) What is claimed is: 1.  A compound having the formula  (Chemical Structure image '5' not included in text)  wherein R is selected from the group consisting of hydrogen and a radical having the formula  (Chemical Structure image '6' not included in text)  or a pharmaceutically acceptable prodrug thereof. 7. A method of treating a fungal infection in a patient in need of such treatment, comprising administering to the patient a therapeutically effective amount of a compound according to claim 1. 2. A compound according to claim 1 wherein R is hydrogen. 3. A compound according to claim 1 wherein R is a radical having the formula  (Chemical Structure image '7' not included in text)  4.  A pharmaceutical composition comprising a compound according to claim 1 in combination with a pharmaceutically acceptable carrier. 5. A pharmaceutical composition comprising a compound according to claim 2 in combination with a pharmaceutically acceptable carrier. 6. A pharmaceutical composition comprising a compound according to claim 3 in combination with a pharmaceutically acceptable carrier. 8. A method of treating a fungal infection in a patient in need of such treatment, comprising administering to the patient a therapeutically effective amount of a compound according to claim 2. 9. A method of treating a fungal infection in a patient in need of such treatment, comprising administering to the patient a therapeutically effective amount of a compound according to claim 3. 10. A process for preparing a compound according to claim 1, comprising the steps of (a) culturing a microorganism having the characteristics of Fusarium species AB 1900A-1314 under suitable conditions in a fermentation medium containing assimilable sources of carbon and nitrogen; (b) allowing the compound to accumulate in the fermentation medium;  and (c) isolating the compound from the fermentation medium. 11. A process according to claim 10 wherein the microorganism is Fusarium strain NRRL 21252.
法律状态
(US5585251) LEGAL DETAILS FOR US5585251  Actual or expected expiration date=2005-01-19    Legal state=DEAD    Status=LAPSED     Event publication date=1995-01-10  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US08370934  Application date=1995-01-10  Standardized application number=1995US-08370934     Event publication date=1995-01-10  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: PESELEV, ELLI    Event publication date=1995-01-10  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1211     Event publication date=1995-01-10  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 5642.US.01    Event publication date=1995-01-10  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=1995-01-10  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=1995-03-15  Event code=US/TRDD  Event type=APL  Decision by documentation    Event publication date=1995-08-07  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=1995-08-07  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=1996-01-24  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=1996-05-20  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=1996-05-20  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=1996-05-31  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=1996-06-17  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=1995-01-10  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:ALDER, LISA A. BURRES, NEAL S. HOCHLOWSKI, JILL E. AND OTHERS REEL/FRAME:008009/0955     Event publication date=1996-11-12  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=1996-12-17  Event code=US/A  Event indicator=Pos  Event type=Event indicating In Force  Patents Granted before 2001-04-15  Publication country=US  Publication number=US5585251  Publication stage Code=A  Publication date=1996-12-17  Standardized publication number=US5585251     Event publication date=1999-12-28  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=3     Event publication date=2000-03-31  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2000-03-31     Year of payment of annual fees=4     Event publication date=2003-12-30  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=7     Event publication date=2004-07-07  Event code=US/REMI  Event type=Administrative notifications  Maintenance fee reminder mailed    Event publication date=2004-12-17  Event code=US/FP  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Expired due to failure to pay maintenance fee  Effective date of the event=2004-12-17     Event publication date=2004-12-17  Event code=US/LAPS  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Lapse for failure to pay maintenance fees    Event publication date=2005-01-19  Event code=US/FP  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=Payment or non-payment notifications  Expired due to failure to pay maintenance fee    Event publication date=2005-01-19  Event code=US/EXP  Event indicator=Neg  Event type=Event indicating Not In Force  Patent expired
专利类型码
A
国别省市代码
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