Topical administration of pharmacologically active bases in the treatment of inflammatory dermatoses 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2003235626 A1 2003-12-25 [US20030235626]US6943197 B2 2005-09-13 [US6943197] / 2003-12-252005-09-13
申请号/申请日
2002US-10176962 / 2002-06-21
发明人
MAIBACH HOWARD I;LUO ERIC C;HSU TSUNG-MIN;
申请人
STAPLETON JOHN;
主分类号
IPC分类号
A61K-008/19A61K-008/41A61K-008/42A61K-031/13A61K-033/00A61K-033/02A61K-033/08A61K-047/02A61K-047/16A61P-017/00A61P-017/06A61P-017/10A61P-031/02A61P-037/02A61Q-019/00
摘要
(US6943197) Provided are methods and topical pharmaceutical formulations for the treatment of inflammatory dermatoses.  The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.  These basic formulations are particularly suited to the treatment of acne vulgaris.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2002US-10176962 2002-06-21
主权利要求
(US6943197) 1. A method of treating an individual afflicted with an inflammatory dermatosis, comprising topically applying to an affected area of the individual's skin a formulation consisting essentially of a pharmaceutically acceptable topical carrier and an active agent selected from pharmacologically active inorganic hydroxides and mixtures thereof, wherein the active agent is present at a concentration sufficient to provide a formulation pH in the range of approximately 7.5 to 13.0. 2. The method of claim 1, wherein the inflammatory dermatosis is selected from the group consisting of allergic dermatoses, pruritic dermatoses, vascular dermatoses, sebaceous gland disorders, papulosquamous dermatoses, bacterial dermatoses, viral dermatoses, mycolic skin infections, granulomatous dermatoses, parasitic skin dermatoses, exfoliative dermatitis, bullous dermatoses, pigmented dermatoses, photosensitive dermatoses, dermatoses caused by collagen diseases, and dermatoses due to internal diseases. 3. The method of claim 2, wherein the inflammatory dermatosis is a sebaceous gland disorder. 4. The method of claim 3, wherein the sebaceous gland disorder is an acneiform disorder. 5. The method of claim 4, wherein the acneiform disorder is selected from the group consisting of acne vulgaris, acne conglombata, hidradenitis suppurativa, acne rosacea, seborrhea, seborrheic dermatitis, gram negative folliculitis, pyoderma faciale, steatocystoma multiplex, sebaceous hyperplasia, and rhinophyma. 6. The method of claim 5, wherein the acneiform disorder is acne vulgaris. 7. The method of claim 2, wherein the inflammatory dermatosis is a papulosquamous dermatosis. 8. The method of claim 7, wherein the papulosquamous dermatosis is psoriasis. 9. The method of claim 1, wherein the inflammatory dermatosis is an autoimmune condition. 10. The method of claim 9, wherein the autoimmune condition is atopic dermatitis, mast cell disease, bullous pemphigoid, pemphigus vulgaris, necrotizing vasculitis, discoid lupus erythematosus, systemic lupus erythematosis, or dermatitis herpetiformis. 11. The method of claim 1, wherein the pH is in the range of approximately 8.0 to 11.5. 12. The method of claim 11, wherein the pH is in the range of approximately 8.5 to 10.5. 13. The method of claim 1, wherein the formulation is aqueous. 14. The method of claim 13, wherein the aqueous formulation is selected from the group consisting of a cream, a gel, a lotion, and a solution. 15. The method of claim 14, wherein the aqueous formulation is a cream. 16. The method of claim 14, wherein the aqueous formulation is a gel. 17. The method of claim 14, wherein the aqueous formulation is a lotion. 18. The method of claim 14, wherein the aqueous formulation is a solution. 19. The method of claim 1, wherein the inorganic hydroxide is selected from the group consisting of ammonium hydroxide, alkali metal hydroxides, alkaline earth metal hydroxides, and mixtures thereof. 20. The method of claim 19, wherein the inorganic hydroxide is selected from the group consisting of ammonium hydroxide, sodium hydroxide, calcium hydroxide, potassium hydroxide, magnesium hydroxide, and mixtures thereof. 21. The method of claim 20, wherein the inorganic hydroxide is sodium hydroxide. 22. The method of claim 1, wherein the formulation is applied periodically over an extended time period. 23. The method of claim 1, wherein the formulation is applied approximately twice weekly. 24. The method of claim 1, wherein the formulation is applied once daily. 25. The method of claim 1, wherein the formulation is applied twice daily. 26. The method of claim 1, wherein the formulation is applied on an as-needed basis. 27. The method of claim 22, wherein said extended time period is at least three months. 28. The method of claim 27, wherein said extended time period is at least four months. 29. A topical formulation for treating an inflammatory dermatosis, consisting essentially of a pharmaceutically acceptable topical carrier and an active agent selected from pharmacologically active inorganic hydroxides and mixtures thereof, wherein the active agent is present at a concentration sufficient to provide a formulation pH in the range of approximately 7.5 to 3.0. 30. The formulation of claim 29, wherein the pH is in the range of approximately 8.0 to 11.5. 31. The formulation of claim 30, wherein the pH is in the range of approximately 8.5 to 10.5. 32. The formulation of claim 28, wherein the carrier is aqueous. 33. The formulation of claim 32, selected from the group consisting of a cream, a gel, a lotion, and a paste. 34. The formulation of claim 33, in the form of a cream. 35. The formulation of claim 33, in the form of a gel. 36. The formulation of claim 33, in the form of a lotion. 37. The formulation of claim 33, in the form of a paste. 38. The formulation of claim 29, wherein the inorganic hydroxide is selected from the group consisting of ammonium hydroxide, alkali metal hydroxides, alkaline earth metal hydroxides, and mixtures thereof. 39. The formulation of claim 38, wherein the inorganic hydroxide is selected from the group consisting of ammonium hydroxide, sodium hydroxide, calcium hydroxide, potassium hydroxide, magnesium hydroxide, and mixtures thereof. 40. The formulation of claim 39, wherein the inorganic hydroxide is sodium hydroxide.
法律状态
(US6943197) LEGAL DETAILS FOR US2003235626  Actual or expected expiration date=2013-10-14    Legal state=DEAD    Status=LAPSED     Event publication date=2002-06-21  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US10176962  Application date=2002-06-21  Standardized application number=2002US-10176962     Event publication date=2002-06-21  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: GEORGE, KONATA M    Event publication date=2002-06-21  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1616     Event publication date=2002-06-21  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status Business Entity Status: SMALL    Event publication date=2002-06-21  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2002-06-21  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 5011-005    Event publication date=2002-06-21  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 44163    Event publication date=2002-07-25  Event code=US/INCD  Event type=Examination events  Event type=OAO  Notice Mailed--Application Incomplete--Filing Date Assigned    Event publication date=2002-12-23  Event code=US/FPAFF  Event type=Payment or non-payment notifications  Payment of additional filing fee/Preexam    Event publication date=2003-04-03  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2003-06-27  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2003-10-06  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2003-10-06  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2003-12-19  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2003-12-25  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2003235626  Publication stage Code=A1  Publication date=2003-12-25  Standardized publication number=US20030235626     Event publication date=2004-02-23  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2004-04-28  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2004-07-26  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2004-09-21  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2005-01-24  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2005-01-26  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2005-05-18  Event code=US/M327  Event type=Examination events  Event type=OAO  Miscellaneous Communication to Applicant - No Action Count    Event publication date=2005-08-09  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2005-08-24  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=2005-09-13  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US6943197  Publication stage Code=B2  Publication date=2005-09-13  Standardized publication number=US6943197     Event publication date=2005-09-13  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 84  Overlap Delays: 0  Non Overlap Delays: 84   PTO Office Delays: 0  Applicant Delays: 141  Adjustment total:  Number of days of extension=0    Event publication date=2006-01-30  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:MAIBACH, HOWARD I. 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专利类型码
A1B2
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