来源期刊：Journal of speech, language, and hearing research: JSLHR
年/卷/期：2018 / 61 / 6
Purpose: One promising early marker for autism and other communicative and language disorders is early infant speech production. Here we used daylong recordings of high-and low-risk infant-mother dyads to examine whether acoustic-prosodic alignment as well as two automated measures of infant vocalization are related to developmental risk status indexed via familial risk and developmental progress at 36 months of age.
Fractures in sport are a specialised cohort of fracture injuries,occurring in a high functioning population,in which the goals are rapid restoration of function and return to play with the minimal symptom profile possible.While the general principles of fracture management,namely accurate fracture reduction,appropriate immobilisation and timely rehabilitation,guide the treatment of these injuries,management of fractures in athletic populations can differ significantly from those in the general population,due to the need to facilitate a rapid return to high demand activities.However,despite fractures comprising up to 10%of all of sporting injuries,dedicated research into the management and outcome of sport-related fractures is limited.In order to assess the optimal methods of treating such injuries,and so allow optimisation of their outcome,the evidence for the management of each specific sport-related fracture type requires assessment and analysis.We present and review the current evidence directing management of fractures in athletes with an aim to promote valid innovative methods and optimise the outcome of such injuries.From this,key recommendations are provided for the management of the common fracture types seen in the athlete.Six case reports are also presented to illustrate the management planning and application of sport-focussed fracture management in the clinical setting.
Andersen, Anna H. F.;Riber, Camilla F.;Zuwala, Kaja;Tolstrup, Martin;Dagnaes-Hansen, Frederik;Denton, Paul W.;Zelikin, Alexander N.
来源期刊：ACS Macro Letters
年/卷/期：2018 / 7 / 5
Antiretroviral therapy (ART) has revolutionized HIV treatment, yet grand challenges remain: (i) short blood and body residence time of the antiviral drugs, (ii) relative poor antiretroviral drug penetrance into key tissue reservoirs of viral infection, namely, the spleen and lymph nodes, and (iii) obstacles in different pharmacokinetics of the necessary combination drugs. We present a novel drug delivery approach that simultaneously overcomes these limitations. We designed albumin polymer drug conjugates where albumin ensures long body residence time as well as lymphatic accumulation of the conjugate. The polymer enabled the delivery of combinations of drugs in precise ratios affording potency superior to the individual antiretroviral drugs and strong protection from HIV infection in primary human T cells.
Kim, Han-Suk;Yu, Kyung-Sang;Kim, Yu Kyong;Lee, Juyoung;Oh, Jaeseong;Rhee, Su-jin;Shin, Seung Han;Yoon, Seo Hyun;Lee, SeungHwan
来源期刊：Antimicrobial agents and chemotherapy.
年/卷/期：2019 / 63 / 6
Fluconazole is an antifungal agent with reported evidence for its prophylactic effect against systemic fungal infection in preterm infants. The aim of this study was to build a population pharmacokinetic model to evaluate the pharmacokinetic characteristics of intravenous and oral fluconazole in preterm infants with the current prophylactic fluconazole dosing regimen. A pharmacokinetic model was developed using 301 fluconazole concentrations from 75 preterm infants with a baseline body weight (WT) ranging from 0.5 to 1.5 kg and an estimated glomerular filtration rate (eGFR) ranging from 12.9 to 58.5 ml/min/1.73 m(2). Eligible infants received an intravenous or oral dose of 3 mg/kg of body weight of fluconazole, twice weekly with a >= 72-h dose interval, for 4 weeks. The model was qualified with basic goodness-of-fit diagnostics, visual predictive checks, and bootstrapping. The fluconazole pharmacokinetics was well described with a one-compartment linear model with a proportional residual error. The population clearance (CL) and volume of distribution (V) were derived as 0.0197 x (WT/1.00)(0.746) x (eGFR/25.0)(0.463) x exp(eta) and 1.04 x WT x exp(eta), respectively. Such covariate analyses augment the awareness of the need for personalized dosing in preterm infants.
The prototype for transgender women is Tiresias of Greek mythology, a shepherd's son who struck copulating snakes with his crook, and for this impiety was changed into a woman by Hera, wife of Zeus. Tiresias as a woman married and bore children-the transformation into a woman became complete. The wisdom of the ancients suggests that Bruno and Arora in this issue (Bruno and Arora 2018) err in dismissing the acceptability of uterus transplantation in transgender women.