Purpose: One promising early marker for autism and other communicative and language disorders is early infant speech production. Here we used daylong recordings of high-and low-risk infant-mother dyads to examine whether acoustic-prosodic alignment as well as two automated measures of infant vocalization are related to developmental risk status indexed via familial risk and developmental progress at 36 months of age.

中国是一个“缺油、少气、相对富煤”的国家，针对当前我国经济持续高速发展的特定时期，以及石油、天然气等资源日渐短缺的严峻形势，煤炭资源的最大限度利用以及开发洁净煤技术已然成为适应中国经济和社会稳定发展的潮流。以次烟煤和褐煤为代表的低阶煤约占我国煤炭探明储量的45.68％，探明储量高达523亿吨。神东煤作为低变质烟煤的代表，具有高挥发分、低灰低硫的特点，是适合现代煤化工发展所需的煤种。本文以TG-FTIR联用仪、粉-粒流化床对神东煤以及液化残渣的单独热解及共热解进行研究，探讨液化残渣的添加量对于共热解产率及产物分布的影响，并进一步利用TG-FTIR联用仪探讨液化残渣各组分对共热解的影响。 采用TG-FTIR对神东煤和液化残渣的共热解进行研究，考察液化残渣添加量对神东煤热解转化率的影响并对共热解过程进行动力学分析。结果表明:掺混液化残渣对神东煤热解转化率有促进作用，其中加入6.18％液化残渣的热解实际转化率最高，达到37.47％,其余依次为10％、3.82％以及2.36％的液化残渣添加量，适量的液化残渣添加能起到最佳热解作用。将液化残渣中各组分分别与煤共热解，在800℃热解终温处，最佳共热解组分依次为PA、HS、THFIS和A。 采用粉-粒流化床热解实验装置对神东煤和液化残渣的快速热解进行研究，主要考察热解温度对神东煤热解的影响以及液化残渣添加量对共热解的影响。对实验结果分析得出:随着设定终温的变高，热解焦油产率呈先增大后减少的趋势，热解气产率一直增大，半焦产率则逐渐降低并在650℃-700℃时趋于稳定，确定了共热解实验中热解温度设定在600℃;共热解过程中，热解焦油产率随液化残渣的添加量增大而增多，当残渣掺混比例在10％时，焦油实际产率最大达到17.65％，热解半焦产率则随液化残渣添加量增加而减少，液化残渣添加量为10％时，半焦实际产率最低，仅为63.80％。

由佛山市北朝源科技服务有限公司申请的专利(公开号CN 107652615A,公开日期2018-02-02)"一种工业设备电缆护套用氯磺化聚乙烯橡胶材料",涉及的材料配方(质量分数)为:氯磺化聚乙烯橡胶0.4～0.5,氯丁橡胶0.001～0.03,丙烯腈-丁二烯-苯乙烯塑料0.4～0.6,二甲基乙醇胺0.001～0.01,聚二甲基硅氧烷0.001～0.03,辛酸亚锡

以采用AAO污水处理工艺的德清县狮山污水处理厂作为全耦合活性污泥模型(FCASM3)校验的现场试验基地,分别进行了常规水质指标测定和进水水质特征分析等试验研究.依据现场试验结果,完成了对活性污泥系统生物去除营养物质细观机理模型FCASM3的校验工作.动态校验结果表明,FCASM3模型可以对AAO连续流工艺系统实现较准确的细观模拟,营养物质生物去除过程的动态数值模拟结果与实测结果相一致.

Fractures in sport are a specialised cohort of fracture injuries,occurring in a high functioning population,in which the goals are rapid restoration of function and return to play with the minimal symptom profile possible.While the general principles of fracture management,namely accurate fracture reduction,appropriate immobilisation and timely rehabilitation,guide the treatment of these injuries,management of fractures in athletic populations can differ significantly from those in the general population,due to the need to facilitate a rapid return to high demand activities.However,despite fractures comprising up to 10%of all of sporting injuries,dedicated research into the management and outcome of sport-related fractures is limited.In order to assess the optimal methods of treating such injuries,and so allow optimisation of their outcome,the evidence for the management of each specific sport-related fracture type requires assessment and analysis.We present and review the current evidence directing management of fractures in athletes with an aim to promote valid innovative methods and optimise the outcome of such injuries.From this,key recommendations are provided for the management of the common fracture types seen in the athlete.Six case reports are also presented to illustrate the management planning and application of sport-focussed fracture management in the clinical setting.

Antiretroviral therapy (ART) has revolutionized HIV treatment, yet grand challenges remain: (i) short blood and body residence time of the antiviral drugs, (ii) relative poor antiretroviral drug penetrance into key tissue reservoirs of viral infection, namely, the spleen and lymph nodes, and (iii) obstacles in different pharmacokinetics of the necessary combination drugs. We present a novel drug delivery approach that simultaneously overcomes these limitations. We designed albumin polymer drug conjugates where albumin ensures long body residence time as well as lymphatic accumulation of the conjugate. The polymer enabled the delivery of combinations of drugs in precise ratios affording potency superior to the individual antiretroviral drugs and strong protection from HIV infection in primary human T cells.

江苏丁酮市场气氛一般，场内气氛一般，目前，国产货源报价意向在8300-8400元/吨,商谈重心在8300元/吨附近。

Fluconazole is an antifungal agent with reported evidence for its prophylactic effect against systemic fungal infection in preterm infants. The aim of this study was to build a population pharmacokinetic model to evaluate the pharmacokinetic characteristics of intravenous and oral fluconazole in preterm infants with the current prophylactic fluconazole dosing regimen. A pharmacokinetic model was developed using 301 fluconazole concentrations from 75 preterm infants with a baseline body weight (WT) ranging from 0.5 to 1.5 kg and an estimated glomerular filtration rate (eGFR) ranging from 12.9 to 58.5 ml/min/1.73 m(2). Eligible infants received an intravenous or oral dose of 3 mg/kg of body weight of fluconazole, twice weekly with a >= 72-h dose interval, for 4 weeks. The model was qualified with basic goodness-of-fit diagnostics, visual predictive checks, and bootstrapping. The fluconazole pharmacokinetics was well described with a one-compartment linear model with a proportional residual error. The population clearance (CL) and volume of distribution (V) were derived as 0.0197 x (WT/1.00)(0.746) x (eGFR/25.0)(0.463) x exp(eta) and 1.04 x WT x exp(eta), respectively. Such covariate analyses augment the awareness of the need for personalized dosing in preterm infants.

The prototype for transgender women is Tiresias of Greek mythology, a shepherd's son who struck copulating snakes with his crook, and for this impiety was changed into a woman by Hera, wife of Zeus. Tiresias as a woman married and bore children-the transformation into a woman became complete. The wisdom of the ancients suggests that Bruno and Arora in this issue (Bruno and Arora 2018) err in dismissing the acceptability of uterus transplantation in transgender women.

普遍存在于自然界的电解质溶液体系,在环境化学和生物工程等方面有着广泛的应用,因此对电解质溶液的热力学性质的研究非常重要。特别是,活度系数和其他相关的物理量,如渗透系数、过量吉布斯自由能、标准迁移吉布斯自由能以及原水化数能够直接反应电解质溶液中的离子一离子、离子一溶剂之间的相互作用,从而预测出电解质溶液偏离理想溶液的程度。 基于本课题组长期研究铷铯盐溶液体系热力学的性质,论文开展了对氟化铷/氟化铯在酰胺(甲酰胺,N-甲基甲酰胺,N,N-二甲基甲酰胺,N,N-二甲基乙酰胺)和水体系中的热力学性质探究。 1.用无液接电位的可逆电池：Rb/Cs-ISE|RbF/CsF (m), Amides (w), H20(1-w)|F-ISE,测定了2-98.15K下氟化铷/氟化铯在酰胺一水溶液中的电动势。将Nemst方程分别与Pitzer模型、扩展的Debye-Hiikel模型以及修正Pitzer模型联合,得到了体系的平均离子活度系数γ±,并计算了渗透系数Φ、过量吉布斯自由能GE、标准迁移吉布斯自由能△Gt0和原水化数nhydr。 2. RbF/CsF在混合溶剂中的平均离子活度系数γ±和过量吉布斯自由能GE均随其质量摩尔浓度的增大而减小,随FA/NMF-H2O体系的质量分数增大而增大,随DMF/DMA-H2O体系的质量分数增大而减小。该现象可由静电相互作用模型和混合溶剂的性质来解释。 3.标准迁移吉布斯自由能△Gt0都大于零,且随共溶剂含量的增加而增加,表明迁移过程为非自发过程。 4.计算出的原水化数nhydr,较好地反映出在不同混合溶剂中RbF/CsF溶剂化作用的差异。