[专利]
Mixed solvate of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl] -8-hydroxy-1h-quinolin-2-one l-tartrate
申请号:
2016WO-EP73355
申请日:
2016-09-29
公开号:
WO2017055506 A1 2017-04-06 [WO201755506]
公开日:
2017-04-06
申请人:
LESVI LABORATORIOS
专利权人:
LESVI LABORATORIOS
发明人:
CAPDEVILA URBANEJA ENRIC;HUGUET CLOTET JUAN;DALMASES BARJOAN PERE
国家:
(WO201755506) The present invention provides an improved process for the manufacture of indacaterol or a pharmaceutically acceptable salt thereof, preferably indacaterol maleate, in high chemical and enantiomeric purity and high yield, via a mixed solvate of (R)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one L-tartrate salt, compound of formula (II).