[专利]
Compositions and methods for prevention and treatment of cancer
申请号:
2016JP-0159414
申请日:
2016-08-16
公开号:
JP2017014255 A 2017-01-19 [JP2017014255]
公开日:
2017-01-19
申请人:
UTI PARTNERSHIP
专利权人:
UTI PARTNERSHIP
IPC:
A61K-009/14;A61K-039/00;A61K-039/385;A61K-047/02;A61K-047/50;A61P-035/00;A61P-035/04;A61P-043/00
(JP2017014255) PROBLEM TO BE SOLVED: To provide compositions and methods related to immunotherapy and medicine which expand tumor-specific T cells that can efficiently attack cancerous cells.SOLUTION: The invention provides a method of treating a tumor or cancer in a subject comprising administering to the subject a conjugate, consisting of nanoparticles coated with a tumor specific antigen-presenting MHC class I and/or class II molecule and a costimulatory molecule, in an amount sufficient to expand a population of antigen-specific anti-tumorigenic T cells specific to the tumor or cancer. The antigen-specific anti-tumorigenic T cells include cytotoxic T cells, effector T cells, memory T cells, and helper T cells, which are necessary to initiate and maintain a substantial immune response against metastatic or non-metastatic cancerous, pre-cancerous, or neoplastic cells in vivo. The method comprises a systemic approach targeting cancerous or pre-cancerous cells that are circulating cells in lymphomas and the like, migratory metastatic cells, and solid tumors.SELECTED DRAWING: Figure 2