[专利]
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
申请号:
2015US-14956642
申请日:
2015-12-02
公开号:
US2016151352 A1 2016-06-02 [US20160151352]US9682076 B2 2017-06-20 [US9682076]
公开日:
2016-06-022017-06-20
申请人:
KEMPHARM
专利权人:
KEMPHARM
发明人:
MICKLE TRAVIS;GUENTHER SVEN;BERA SANJIB;KANSKI JAROSLAW;MARTIN ANDREA
国家:
IPC:
A61K-031/44;A61K-031/485;C07D-221/28
(US9682076) The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.