(EP3180622) The invention relates to methods and systems taking advantage of bioinformatic investigations to identify candidate signature peptides for quantitative multiplex analysis of complex protein samples from plants, plant parts, and/or food products using mass spectroscopy. Provided are use and methods for selecting candidate signature peptides for quantitation using a bioinformatic approach. Also provided are systems comprising a chromatography and mass spectrometry for using selected signature peptides. (From WO2016025516 A1)
(EP3180120) The invention pertains to a process for in-situ regeneration of activated carbon loaded with trihalomethane (THM). Based on the invention, this is achieved with alkaline hydrolysis of the THM with increased temperatures within the activated carbon in halogen-free, good water-soluble, or gaseous compounds. After completion of the chemical hydrolysis treatment, the activated carbon is cleared of reagents and reaction products by rinsing with water and diluted acids, and is then available for reloading in the untreated water flow. During the entire cleaning process, the activated carbon bed must not be moved. (From US2017232421 A1)
(EP3180025) The invention provides for a human antibody that binds to human vascular endothelial growth factor receptor 2, preferably ramucirumab, for the treatment of hepatocellular carcinoma in patients having levels of alpha-fetoprotein (AFP) of 1.5 ULN or greater, and as a predictive method for the treatment of HCC in patients having AFP levels of 1.5 x ULN or greater. (From WO2016025464 A1)
(US20170173698) Provided is a method for preparing metal powder; a metal nitrate or metal sulfate is combined with ammonia water to produce an ammonia-containing complex metal salt solution; the said solution is then quantitatively jet-mixed with the solution containing the hydroxylamine compounds, and reacted under intense stirring; a dispersant solution is added during the reaction process, and after the reaction is complete, the solution is separated by centrifugation to yield the metal power. The method of the present invention can effectively control the reaction rate during the production process, and well control the nucleation rate and dispersity, with the produced metal powder having very good crystallinity, sphericity, tap property and dispersity.
(PH12015501802) The present invention is related to an intaglio ink composition comprising a first component A) and a second component B), wherein the first component A) is selected from the group consisting of i) about 0.1 pcnt to about 40 pcnt by weight of a plurality of first particles having a modal particle diameter between about 1 nm and about 3 mm, said plurality of first particles may be a material having machine readable properties, preferably selected from the group consisting of magnetic properties, UV- or IR-absorbing properties, optically variable properties, light polarization properties, electro-conductive properties, luminescent properties and combinations thereof, ii) about 1 pcnt to about 20 pcnt by weight of one or more dyes, said one or more dyes may be a material having machine readable properties preferably selected from the group consisting of IR-absorbing properties, luminescent properties and combinations thereof, and iii) combinations thereof, and the second component B) is about 0.1 pcnt to about 40 pcnt by weight of a plurality of second particles having a modal particle diameter between about 6 mm and about 25 mm, said plurality of second particles may be a material having machine readable properties preferably selected from the group consisting of magnetic properties, UV- or IR-absorbing properties, optically variable properties, light polarization properties, electro-conductive properties and luminescent properties and combinations thereof, wherein the first component A) and the second component B) exhibit at least one different characteristic, said characteristic being selected from the group consisting of the CIE (1976) color index parameters, machine readable properties, and a combination thereof, the pcnt by weight being based on the total weight of the intaglio ink composition.
(CA2957828) The present application relates to novel substituted quinoline-4-carboxamides, which act as stimulators of soluble guanylate cyclase, and to the use thereof, to methods for the production thereof, to the use thereof alone or in combinations to treat and/or prevent diseases, and to the use thereof to produce drugs for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
DUTRY ISABELLE CÉCILE ANGÈLE;IP KIN SUN;CHIU KELVIN;YIM WAI LAM WILLIAM;LAU YIU TING RICHARD
(EP3177920) A portable and completely self-contained apparatus(20) for detecting analyte and the methods of use thereof is described. The apparatus (20) includes a microfluidic cartridge driver unit (30), an optical inspection unit (32), and a control unit (28) and a power supply unit, which can run the binding and detection of the analyte without any fluidic interfaces to the instrument. The microfluidic cartridge driver unit (30) receives microfluidic cartridge (22) that holds a microarray and integrated microfluidic chip (24) for delivering the analyte to perform different process steps in the detection of analyte. A complete detection of analyte using the invention takes only a few minutes. (From US2017209862 A1)
(DE112015003600) In an additive manufacturing method, powder layers are applied to a supporting surface. Then powder is removed from the layer again in regions, the layer thus being contoured. Finally, the layer is fixed. A device for carrying out an additive manufacturing method, comprising a supporting surface, a powder remover, and a fixer, is used for this purpose. (From WO2016019939 A1)