[专利]
Inhibitors of cyclin-dependent kinase 7 (cdk7)
申请号:
2015CA-2972239
申请日:
2015-12-23
公开号:
CA2972239 A1 2016-06-30 [CA2972239]
公开日:
2016-06-30
申请人:
DANA FARBER CANCER INSTITUTE
专利权人:
DANA FARBER CANCER INSTITUTE
发明人:
GRAY NATHANAEL S;LIANG YANKE;ZHANG TINGHU;KWIATKOWSKI NICHOLAS PAUL
国家:
IPC:
A61K-031/5383;A61P-035/00;C07D-487/04
(CA2972239) The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.