(JP2017018137) PROBLEM TO BE SOLVED: To provide induction methods of pluripotent cells.SOLUTION: The method comprises a step of reprogramming human somatic cells in an albumin-free medium containing water, salts, amino acids, vitamins, glucose, insulin, FGF, selenium, transferrin, one of TGF-β, and NODAL, in an amount sufficient to support somatic cell reprogramming to derive each human iPS cell, the defined albumin-free medium not containing a component derived from non-human animals.SELECTED DRAWING: Figure 1A
(JP2017014527) PROBLEM TO BE SOLVED: To provide an exterior component for automobile excellent in jet blackness with depth and clear feeling, heat resistance, weather resistance and impact resistance.SOLUTION: There is provided an exterior component consisting of a polycarbonate resin containing a structural unit derived from a dihydroxy compound represented by the following general formula (1) and a structural unit derived from cyclohexanedimethanol, a coloring agent and a hindered amine-based photostabilizer, where the coloring agent in the resin composition is 0.05 pts.wt. to 5 pts.wt. based on 100 pts.wt. of the polycarbonate resin and the hindered amine-based photostabilizer is 0.001 pts.wt. to 5 pts.wt.SELECTED DRAWING: None
William AM ENDE Christopher;Michael HUMPHREY John;Scott JOHNSON Douglas;Wayne KAUFFMAN Gregory;Youngjin PETTERSSON Martin;Antonia RANKIC Danica;Friederike STEPAN Antonia;Robert VERHOEST Patrick
(IN201617033026) Compounds and pharmaceutically acceptable salts of the compounds are disclosed wherein the compounds have the structure of Formula (I) wherein X R R R R4 R R R R R y and z are as defined in the specification. Corresponding pharmaceutical compositions methods of treatment methods of synthesis and intermediates are also disclosed. These compounds are ? secretase modulators useful for the treatment of neurodegenerative and/ or neurological disorders such as Alzheimer s disease and Down s syndrome.