Totally found 10042821 items.

  • [专利] Predicting s. aureus disease
    (EP3180620) The invention relates to a method for the prediction of S. aureus disease in a subject heavily colonized by S. aureus but not showing any symptom of S. aureus disease, said method comprising the step of determining the alpha haemolysin level in a biological sample of said subject as compared to a standard or reference control, wherein an elevated alpha haemolysin level or activity is indicative of the onset of S. aureus disease. (From WO2016023943 A1)
  • [专利] Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
    (EP3180002) Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer. (From WO2016024233 A1)
  • [专利] Chimeric antigen receptor specific for ssea4 antigen
    (CA2958757) The present invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain specific for SSEA4, a population of engineered cells expressing said CARs, and a pharmaceutical composition comprising said genetically modified cells expressing said CARs. The pharmaceutical composition may be for use of the treatment of cancer in a subject suffering from cancer, wherein at least a subpopulation of the cancerous cells of said cancer expresses SSEA4.
  • [专利] Method of detection of analyte active forms and determination of the ability of substances to bind into analyte active sites
    (EP3177931) A method for detection of active form of analytes in a sample and/or for determination of ability of tested substances to bind to the active site of these analytes has the following steps: a) analyte or group of analytes from the sample is immobilized on the surface of a solid carrier; b) analyte or group of analytes is incubated with a detection probe; c) then the solid carrier is washed to remove unbound detection probe; and subsequently, the amount of bound detection probe is determined. (From US2017219583 A1)
  • [专利] Method for obtaining stabilized lignin having a defined particle-size distribution from a lignin-containing liquid
    (EP3177767) A process for recovering carbonized lignin having a defined grain size distribution from a lignin-containing liquid is provided. The lignin-containing liquid is subjected to a hydrothermal carbonization to convert the lignin into a carbonized lignin and the carbonized lignin is separated from the liquid containing the carbonized lignin. The lignin-containing liquid is subjected to a hydrothermal carbonization at temperatures in the range from about 150° C. to about 280° C. and by adapting the H+ ion concentration in the lignin-containing liquid before and/or during the hydrothermal carbonization the grain size distribution of the carbonized lignin is adjusted. (From US2017247255 A1)
  • [专利] Compositions and methods for identifying and selecting maize plants with resistance to northern leaf blight
    (EP3177133) Compositions and methods useful in identifying and/or selecting maize plants having resistance to northern leaf blight are provided herein. The resistance may be newly conferred or enhanced relative to a control plant. The methods use markers to identify, select and/or construct resistant plants. Maize plants identified, selected, and/or generated by the methods described herein are also provided. (From US2017198362 A1)
  • [专利] ヒドロシリル​化​反応​触媒
    (JP2016024611W) A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of the periodic table, e.g., iron acetate, cobalt acetate, nickel acetate, etc; and a ligand comprising a carbine compound such as 1,3-dimesitylimidazol-2-ylidene, etc.. The hydrosilylation reaction catalyst has excellent handling and storage properties. As a result of using this catalyst, a hydrosilylation reaction can be promoted under gentle conditions. (From WO2016024611 A1)
  • [专利] Method for obtaining stabilized lignin having a defined particle-size distribution from a lignin-containing liquid
    (CA2957461) The invention relates to a method for obtaining stabilized lignin having a defined particle-size distribution from a lignin-containing liquid, wherein prior to and/or during a hydrothermal carbonization, the H+ ion concentration of a lignin-containing liquid is adjusted such that the desired particle-size distribution of the hydrothermal carbonized lignin is obtained, and that it can be separated from the liquid containing the carbonized lignin and can optionally be cleaned.
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  • [专利] 芳香​族​メチロール​化合​物​が​反応​し​た​ノボラック​樹脂​を​含む​レジスト​下層​膜​形成​組成​物
    (JP2016021594W) [Problem] To provide a resist underlayer film for lithography, which has high solubility in a resist solvent (a solvent used in lithography) for developing good film formability by coating and a dry etching rate selectivity lower than that of the resist. [Solution] A resist underlayer film forming composition, which contains a novolac resin containing a structure (C) that is obtained by a reaction between an aromatic ring of an aromatic compound (A) and a hydroxy group-containing aromatic methylol compound (B). The aromatic compound (A) is a component for constituting the structure (C) that is contained in the novolac resin. The hydroxy group-containing aromatic methylol compound (B) is represented by formula (1). The hydroxy group-containing aromatic methylol compound (B) is 2-hydroxybenzyl alcohol, 4-hydroxybenzyl alcohol or 2,6-di-tert-butyl-4-hydroxymethyl phenol. (From WO2016021594 A1)
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