NAGY ESZTER;STULIK LUKAS;ROUHA HARALD;MAGYARICS ZOLTÁN
(EP3180620) The invention relates to a method for the prediction of S. aureus disease in a subject heavily colonized by S. aureus but not showing any symptom of S. aureus disease, said method comprising the step of determining the alpha haemolysin level in a biological sample of said subject as compared to a standard or reference control, wherein an elevated alpha haemolysin level or activity is indicative of the onset of S. aureus disease. (From WO2016023943 A1)
(EP3180002) Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer. (From WO2016024233 A1)
(CA2958757) The present invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain specific for SSEA4, a population of engineered cells expressing said CARs, and a pharmaceutical composition comprising said genetically modified cells expressing said CARs. The pharmaceutical composition may be for use of the treatment of cancer in a subject suffering from cancer, wherein at least a subpopulation of the cancerous cells of said cancer expresses SSEA4.
USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I
USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I
NAVRATIL VACLAV;SACHA PAVEL;SCHIMER JIRI;KONVALINKA JAN;MAJER PAVEL
(EP3177931) A method for detection of active form of analytes in a sample and/or for determination of ability of tested substances to bind to the active site of these analytes has the following steps: a) analyte or group of analytes from the sample is immobilized on the surface of a solid carrier; b) analyte or group of analytes is incubated with a detection probe; c) then the solid carrier is washed to remove unbound detection probe; and subsequently, the amount of bound detection probe is determined. (From US2017219583 A1)
(EP3177767) A process for recovering carbonized lignin having a defined grain size distribution from a lignin-containing liquid is provided. The lignin-containing liquid is subjected to a hydrothermal carbonization to convert the lignin into a carbonized lignin and the carbonized lignin is separated from the liquid containing the carbonized lignin. The lignin-containing liquid is subjected to a hydrothermal carbonization at temperatures in the range from about 150° C. to about 280° C. and by adapting the H+ ion concentration in the lignin-containing liquid before and/or during the hydrothermal carbonization the grain size distribution of the carbonized lignin is adjusted. (From US2017247255 A1)
(EP3177133) Compositions and methods useful in identifying and/or selecting maize plants having resistance to northern leaf blight are provided herein. The resistance may be newly conferred or enhanced relative to a control plant. The methods use markers to identify, select and/or construct resistant plants. Maize plants identified, selected, and/or generated by the methods described herein are also provided. (From US2017198362 A1)
(JP2016024611W) A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of the periodic table, e.g., iron acetate, cobalt acetate, nickel acetate, etc; and a ligand comprising a carbine compound such as 1,3-dimesitylimidazol-2-ylidene, etc.. The hydrosilylation reaction catalyst has excellent handling and storage properties. As a result of using this catalyst, a hydrosilylation reaction can be promoted under gentle conditions. (From WO2016024611 A1)
(CA2957461) The invention relates to a method for obtaining stabilized lignin having a defined particle-size distribution from a lignin-containing liquid, wherein prior to and/or during a hydrothermal carbonization, the H+ ion concentration of a lignin-containing liquid is adjusted such that the desired particle-size distribution of the hydrothermal carbonized lignin is obtained, and that it can be separated from the liquid containing the carbonized lignin and can optionally be cleaned.
(JP2016021594W) [Problem] To provide a resist underlayer film for lithography, which has high solubility in a resist solvent (a solvent used in lithography) for developing good film formability by coating and a dry etching rate selectivity lower than that of the resist. [Solution] A resist underlayer film forming composition, which contains a novolac resin containing a structure (C) that is obtained by a reaction between an aromatic ring of an aromatic compound (A) and a hydroxy group-containing aromatic methylol compound (B). The aromatic compound (A) is a component for constituting the structure (C) that is contained in the novolac resin. The hydroxy group-containing aromatic methylol compound (B) is represented by formula (1). The hydroxy group-containing aromatic methylol compound (B) is 2-hydroxybenzyl alcohol, 4-hydroxybenzyl alcohol or 2,6-di-tert-butyl-4-hydroxymethyl phenol. (From WO2016021594 A1)