[专利]
Diaminotriazole compound useful as protein kinase inhibitor
申请号:
2013JP-0024247
申请日:
2013-02-12
公开号:
JP2013082756 A 2013-05-09 [JP2013082756]
公开日:
2013-05-09
申请人:
VERTEX PHARMACEUTICALS
专利权人:
VERTEX PHARMACEUTICALS
发明人:
SALITURO FRANCESCO G;LEDEBOER MARK W;LEDFORD BRIAN;WANG JIAN;PIERCE ALBERT C;DUFFY JOHN P;MESSERSMITH DAVID
国家:
IPC:
A61K-031/496;A61K-031/506;A61K-031/5377;A61K-031/55;A61K-031/551;A61K-031/5517;A61K-031/553;A61K-045/00;A61P-003/10;A61P-007/00;A61P-009/00;A61P-011/06;A61P-021/00;A61P-025/00;A61P-029/00;A61P-035/00;A61P-035/02;A61P-037/02;A61P-037/04;A61P-037/06;A61P-03
(JP2013082756) PROBLEM TO BE SOLVED: To provide a compound particularly useful as a protein kinase inhibitor for JAK family kinase to deal with the demand to develop a compound as a selective protein kinase inhibitor.SOLUTION: The invention relates to an inhibitor of protein kinase, particularly to the inhibitor of JAK2 and JAK3. The invention also provides a pharmaceutical composition comprising the compound, a process for preparing the compound, and a method of using the composition in the treatment of various disorders. The compound and the pharmaceutical composition thereof are useful for treatment or prevention of various disorders, including, but not limited to, an allergy, asthma, an autoimmune disease such as transplant rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, as well as solid and hematologic malignancies such as leukemia and lymphoma.