Palmer, W. C.;Pai, S-L;Aniskevich, S., III;Logvinov, I. I.;Matcha, G., V;Blackshear, J. L.
年/卷/期：2018 / 50 / 5
Background. Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder that presents with a hypertrophied nondilated left ventricle. In the absence of other known causes of cardiomyopathy, it is often associated with left ventricular outflow tract obstruction during systole, systolic anterior motion of the mitral valve, mitral regurgitation, and increased risk of sudden cardiac death. When HCM coexists with end-stage liver disease, it can be further complicated by cirrhosis-associated cardiovascular abnormalities, including hyperdynamic circulation, systolic and diastolic dysfunction, and electrophysiologic abnormalities.
来源期刊：Angewandte Chemie(A European Journal Chembiochem of Chemical Biology V.2 no.5)
年/卷/期：2001 / V.40 / N.9
Zinc anallogues of bacteriochlorophylls c and d self-assembled in aqueous media phospholipids. A methanol solution of zinc chlorin and #alpha#-lecithin was put in a cellulose tube and the inner methanol solvent was gradually replaced with water by dialysis to form the self-assembled oligomers. Visible absorption spectra of the aqueous solution showed that zinc chlorins formed J-aggregates within the hdyrophobic core of #alpha#-lecithin assemblies and that the supramolecular structure of the aggregates depended upon the stereochemistry at the 3~1-position and the alkyl subsituents at the 8-, 12-, and 17~4-positions of the zinc chlorin. When the aqueous aggregates were prepared with a mixture of 3~1-epimers and/or 8-, 12-, or 17~4-homologues of zinc 3~1-hydroxy-13~1-oxochlorins, the structurally distinct components coaggregates to make scrambled oligomets. However, during the dialysis, zinc 3~1-hdyroxy- and 7~1-hydroxy-13~1-oxochlorins slowly individually aggregated to give two structurally different oligomer units in the cellulose tube. In contrast, if the two zinc chlorin components rapidly self-assembled in an aqueous medium, these components coaggregatged to form scrambled oligomers. The present study shows that both the molecular structure of the pigments and the speed of the oligomerization determine the molecular arrangement in chlorosome-type self-assembled oligomers.
Neetu Jindal;Preeti Ranjan Panda;Smruti R. Sarangi
会议集名/来源：2017 Design, Automation & Test in Europe Conference & Exhibition : [Volume 1 of 3] Pages 1-605.
With the increasing complexity of modern Systems-on-Chip, the possibility of functional errors escaping design verification is growing. Post-silicon validation targets the discovery of these errors in early hardware prototypes. Due to limited visibility and observability, dedicated design-for-debug (DFD) hardware such as trace buffers are inserted to aid postsilicon validation. In spite of its benefit, such hardware incurs area overheads, which impose size limitations. However, the overhead could be overcome if the area dedicated to DFD could be reused in-field. In this work, we present a novel method for reusing an existing trace buffer as a victim cache of a processor to enhance performance. The trace buffer storage space is reused for the victim cache, with a small additional controller logic. Experimental results on several benchmarks and trace buffer sizes show that the proposed approach can enhance the average performance by up to 8.3 % over a baseline architecture. We also propose a strategy for dynamic power management of the structure, to enable saving energy with negligible impact on performance.